Mitochondrial carbonic anhydrases VA and VB: Metabolic roles and clinical significance [0.03%]
线粒体碳酸酐酶VA和VB：代谢作用及临床意义
Stanislav Kalinin,Seppo Parkkila,Ashok Aspatwar
Stanislav Kalinin
Mitochondrial carbonic anhydrases VA and VB (CA VA and CA VB) are localized within the mitochondrial matrix. These zinc-containing enzymes catalyze the reversible hydration of carbon dioxide to bicarbonate and protons, thereby providing bic...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
Carbonic anhydrases (CAs, EC 4.2.1.1) are zinc-dependent metalloenzymes that catalyze the reversible hydration of carbon dioxide, a reaction essential for acid-base regulation, respiration, and metabolic integration in vertebrates. In anima...
Andrea Trabocchi
Andrea Trabocchi
The transformation of peptides into drug leads is an established approach in medicinal chemistry and drug discovery. Peptidomimetics are designed to mimic the bioactivity of peptides while addressing their limitations, such as poor metaboli...
Alessandro Bonardi
Alessandro Bonardi
Viral proteases are critical enzymes that play essential roles in the replication of viruses such as Human Immunodeficiency, Hepatitis C, SARS-CoV-2, Zika, Dengue, West Nile, Yellow Fever, Japanese and Saint Louis Encephalitis, Tick-Born En...
Challenges for developing selective viral protease inhibitors as antiinfectives [0.03%]
开发选择性病毒蛋白酶抑制剂作为抗菌药物的挑战
Claudiu T Supuran,Luigi Pisano
Claudiu T Supuran
The biochemical machinery of most viruses comprises proteases which are crucial for their life cycle. In the last decades, proteases from pathogenic viruses started to be considered as potential drug targets, and this led to the development...
Bacteriophage endolysins [0.03%]
噬菌体内溶酶
Nidhi Prajapati,Dharmendra Prajapati,Anil Patani et al.
Nidhi Prajapati et al.
In the last phase of their life cycle, bacteriophages form lytic enzymes known as bacteriophage endolysins that destroy the bacterial cell wall and liberate new virions. Endolysins have emerged as high-scope antimicrobial agents, especially...
Flaviviruses proteases [0.03%]
黄病毒科蛋白酶
Lorenzo Zammarchi,Flavia Chechi,Michele Spinicci et al.
Lorenzo Zammarchi et al.
West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV) are vector-borne diseases endemic in tropical and subtropical countries around the world. Their incidence has been growing in recent years and they are becoming increasingly ...
Ahmed E Elsawi,Haytham O Tawfik,Wagdy M Eldehna
Ahmed E Elsawi
The multipurpose enzyme papain-like protease (PLpro) is crucial for both immune evasion and viral multiplication. The replication-transcription complex is formed when PLpro, encoded by nonstructural protein 3 (nsp3), cleaves the viral polyp...
Viral proteases: Structural basis of function, evolution, and drug design [0.03%]
病毒蛋白酶：功能、进化和药物设计的结构基础
Luigi Franklin Di Costanzo
Luigi Franklin Di Costanzo
Viral proteases are essential enzymes that orchestrate the maturation of viral polyproteins, a critical step in infectious viral particles. Understanding their structure and function is paramount for developing effective antiviral therapies...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
The SARS-CoV-2 main protease (Mpro) plays a pivotal role in the viral life cycle by cleaving polyproteins pp1a and pp1ab into functional non-structural proteins (NSPs), including components essential for RNA replication, such as nsp7, nsp8,...