Luigi Pisano,Claudiu T Supuran
Luigi Pisano
The biochemical machinery of all viruses comprises enzymes able to cleave polyproteins formed after the transcription of the viral genetic material, which belong to the protease class. Viral proteases known so far belong to the aspartic, se...
Niccolò Paoletti,Claudiu T Supuran,Clemente Capasso
Niccolò Paoletti
Sordaria macrospora, a coprophylous fungus used for the last three decades as a model organism for studying fruiting body development of fungi, encodes for four carbonic anhydrases (CAs, EC 4.2.1.1), CAS1-CAS4. CAS1-CAS3 are β-CAs and were...
Silvia Selleri,Andrea Angeli
Silvia Selleri
Carbonic anhydrases (CAs) are essential metalloenzymes that catalyse the reversible conversion of CO₂ to bicarbonate, playing a crucial role in pH regulation, CO₂ sensing, and metabolic homeostasis. In Malassezia species, β-class CAs hav...
Saccharomyces cerevesiae, Candida spp. and Cryptococcus neoformans β-CAs [0.03%]
酿酒酵母(Saccharomyces cerevisiae)、假丝酵母(Candida sp.)和新孢酵母(Cryptococcus neoformans)的β-碳ic酸酐酶
Anna Di Fiore,Martina Buonanno,Davide Esposito et al.
Anna Di Fiore et al.
Carbonic anhydrases are ubiquitous metalloenzymes which catalyze the CO2 hydration to bicarbonate and proton. β-Carbonic Anhydrases from fungi, such as Saccharomyces cerevisiae, Candida spp. and Cryptococcus neoformans, have been widely in...
Challenges for developing selective fungal/protozoal carbonic anhydrase inhibitors as anti-infectives [0.03%]
开发选择性真菌/原生动物碳酐酶抑制剂作为抗菌剂的挑战
Claudiu T Supuran
Claudiu T Supuran
Carbonic anhydrases (CAs, EC 4.2.1.1) were characterized in several fungi (Cryptococcus neoformans, Candida albicans and C. glabrata, Saccharomyces cerevisiae, Malassezia globosa, M. restricta and M. pachydermatis, Sordaria macrospora, Aspe...
Seppo Parkkila
Seppo Parkkila
Amoebiasis, caused by Entamoeba histolytica, remains a major public health issue, particularly in developing countries with poor sanitation. It is also a significant challenge among those who travel to endemic areas, causing, in many cases,...
Fungal α-carbonic anhydrases [0.03%]
真菌α碳酸酐酶
Katia D&#x;Ambrosio,Anna Di Fiore,Vincenzo Alterio et al.
Katia D&#x;Ambrosio et al.
Carbonic anhydrases (CAs) are widely distributed in the fungal kingdom and play crucial roles for their growth, development, virulence, and survival. Known fungal CAs belong either to the α- or the β-classes, with the α-class encoded onl...
Seppo Parkkila
Seppo Parkkila
Trichomoniasis is the most common sexually transmitted infection. It is caused by the parasite Trichomonas vaginalis. Nitroimidazoles, particularly metronidazole and tinidazole, have been the main treatment options for decades. They still r...
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Carbonic anhydrases (CAs) play an essential role in the physiology and survival of protozoan parasites. This study explores the biological functions, molecular features, and therapeutic potential of protozoan CAs, focusing on the α, β, an...
Alane Beatriz Vermelho,Felipe Raposo P Mansoldo,Veronica Silva Cardoso et al.
Alane Beatriz Vermelho et al.
Neglected tropical diseases (NTDs) such as Chagas disease and leishmaniasis represent significant public health challenges due to limited therapeutic options and the emergence of drug-resistant parasites. This chapter explores the potential...