Craig E Cameron,Jamie J Arnold,Laurie S Kaguni
Craig E Cameron
Jocelyne Piret,Guy Boivin
Jocelyne Piret
Human herpesviruses are large double-stranded DNA viruses belonging to the Herpesviridae family. The main characteristics of these viruses are their ability to establish a lifelong latency into the host with a potential to reactivate period...
Carlos E Catalano,Marc C Morais
Carlos E Catalano
Although the process of genome encapsidation is highly conserved in tailed bacteriophages and eukaryotic double-stranded DNA viruses, there are two distinct packaging pathways that these viruses use to catalyze ATP-driven translocation of t...
John C Marecki,Binyam Belachew,Jun Gao et al.
John C Marecki et al.
RNA viruses cause many routine illnesses, such as the common cold and the flu. Recently, more deadly diseases have emerged from this family of viruses. The hepatitis C virus has had a devastating impact worldwide. Despite the cures develope...
Jacqueto Zephyr,Nese Kurt Yilmaz,Celia A Schiffer
Jacqueto Zephyr
Viral proteases are diverse in structure, oligomeric state, catalytic mechanism, and substrate specificity. This chapter focuses on proteases from viruses that are relevant to human health: human immunodeficiency virus subtype 1 (HIV-1), he...
Dario Oliveira Passos,Min Li,Robert Craigie et al.
Dario Oliveira Passos et al.
The retroviral protein Integrase (IN) catalyzes concerted integration of viral DNA into host chromatin to establish a permanent infection in the target cell. We learned a great deal about the mechanism of catalytic integration through struc...
Tatiana V Ilina,Teresa Brosenitsch,Nicolas Sluis-Cremer et al.
Tatiana V Ilina et al.
All retroviruses encode the enzyme, reverse transcriptase (RT), which is involved in the conversion of the single-stranded viral RNA genome into double-stranded DNA. RT is a multifunctional enzyme and exhibits DNA polymerase and ribonucleas...
Structure and function of negative-strand RNA virus polymerase complexes [0.03%]
负链RNA病毒聚合酶复合物的结构与功能
Jesse D Pyle,Sean P J Whelan,Louis-Marie Bloyet
Jesse D Pyle
Viruses with negative-strand RNA genomes (NSVs) include many highly pathogenic and economically devastating disease-causing agents of humans, livestock, and plants-highlighted by recent Ebola and measles virus epidemics, and continuously ci...
Daniel N Clark,Razia Tajwar,Jianming Hu et al.
Daniel N Clark et al.
Hepatitis B virus (HBV) is a hepatotropic, partially double-stranded DNA virus that replicates by reverse transcription and is a major cause of chronic liver disease and hepatocellular carcinoma. Reverse transcription is catalyzed by the fo...
Nicolas Sluis-Cremer
Nicolas Sluis-Cremer
Reverse transcriptase (RT) is a multifunctional enzyme that has RNA- and DNA-dependent DNA polymerase activity and ribonuclease H (RNase H) activity, and is responsible for the reverse transcription of retroviral single-stranded RNA into do...