Seppo Parkkila
Seppo Parkkila
Carbonic anhydrases (CAs) IV and XV are glycosylphosphatidylinositol (GPI)-anchored membrane-associated enzymes involved in the regulation of pH and ion homeostasis. This review summarizes current knowledge on their structure, post-translat...
Carbonic anhydrase III [0.03%]
碳酸酐酶III型
Alessio Nocentini
Alessio Nocentini
Carbonic anhydrase III (CA III) is a low-activity cytosolic isozyme that is highly expressed in skeletal muscle, liver, adipose tissue, and other tissues where it contributes to redox homeostasis, metabolism, and cell survival. CA III is no...
Challenges and opportunities for developing selective carbonic anhydrase inhibitors and activators for vertebrate isoforms [0.03%]
开发选择性的碳酸酐酶抑制剂和活化剂以作用于脊椎动物同工酶的机遇与挑战
Claudiu T Supuran
Claudiu T Supuran
Carbonic anhydrase (CA, EC 4.2.1.1) inhibitors of the sulfonamide/sulfamate type, such as acetazolamide, thiazides/high-ceiling diuretics, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, antiepileptics (sulthiame...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
Carbonic anhydrase (CA, EC 4.2.1.1) isoforms I (CA I) and II (CA II) are widespread cytosolic proteins in most vertebrates. They are abundant in the red blood cells and many other tissues, being involved in physiological processes such as p...
Carbonic anhydrase XIV [0.03%]
碳酸酐酶十四号肽
Giuseppina De Simone,Vincenzo Alterio
Giuseppina De Simone
The carbonic anhydrase (CA) family comprises several isozymes with distinct cellular localizations and physiological functions. In mammals, sixteen different CA isozymes have been characterized to date, while additional isoforms have been i...
Carbonic anhydrase XIII [0.03%]
碳酸酐酶十三型
Alessandro Bonardi
Alessandro Bonardi
Carbonic anhydrase XIII (CA XIII) is a recently identified member of the α-carbonic anhydrase family and a cytosolic enzyme with conserved structural and catalytic features. Since its discovery in 2004, its gene organization, protein struc...
Katia D&#x;Ambrosio,Emma Langella,Simona Maria Monti et al.
Katia D&#x;Ambrosio et al.
The membrane-associated carbonic anhydrases (CAs) IX and XII have emerged as critical players in cancer biology due to their significant expression in various malignancies. The two enzymes differ in catalytic efficiency, with CA IX acting a...
Carbonic anhydrase-related proteins VIII, X, and XI: Evolutionary divergence and emerging biological roles [0.03%]
碳酸酐酶相关蛋白VIII、X和XI：进化及生物学功能研究进展
Ashok Aspatwar,Seppo Parkkila
Ashok Aspatwar
Carbonic anhydrases (CAs) constitute a large family of zinc metalloenzymes best known for catalyzing the reversible hydration of carbon dioxide. Within this family, three isoforms-carbonic anhydrase-related proteins (CARPs) VIII, X, and XI-...
Carbonic anhydrase VII: Development of selective inhibitors and their pharmacological significance [0.03%]
碳酸酐酶VII：选择性抑制剂的开发及其药理意义
Chandra Bhushan Mishra,Claudiu T Supuran
Chandra Bhushan Mishra
Human carbonic anhydrase VII (hCA VII) is a cytosolic zinc metalloenzyme largely expressed in the brain, where it plays an important role in regulating intracellular pH. hCA VII emerged as a valuable therapeutic target for epilepsy and othe...
Carbonic anhydrase VI [0.03%]
碳酸酐酶VI
Tashnuva Rifat,Mathias Sanchez Machado,Marc A Ilies
Tashnuva Rifat
Carbonic anhydrase VI is the only secreted human carbonic anhydrase, identified in saliva, milk, colostrum, in the esophagus and in different parts of the GI tract, in the upper respiratory tract, in lacrimal glands, in serum and in other p...