Andrea Trabocchi
Andrea Trabocchi
The transformation of peptides into drug leads is an established approach in medicinal chemistry and drug discovery. Peptidomimetics are designed to mimic the bioactivity of peptides while addressing their limitations, such as poor metaboli...
Alessandro Bonardi
Alessandro Bonardi
Viral proteases are critical enzymes that play essential roles in the replication of viruses such as Human Immunodeficiency, Hepatitis C, SARS-CoV-2, Zika, Dengue, West Nile, Yellow Fever, Japanese and Saint Louis Encephalitis, Tick-Born En...
Challenges for developing selective viral protease inhibitors as antiinfectives [0.03%]
开发选择性病毒蛋白酶抑制剂作为抗菌药物的挑战
Claudiu T Supuran,Luigi Pisano
Claudiu T Supuran
The biochemical machinery of most viruses comprises proteases which are crucial for their life cycle. In the last decades, proteases from pathogenic viruses started to be considered as potential drug targets, and this led to the development...
Bacteriophage endolysins [0.03%]
噬菌体内溶酶
Nidhi Prajapati,Dharmendra Prajapati,Anil Patani et al.
Nidhi Prajapati et al.
In the last phase of their life cycle, bacteriophages form lytic enzymes known as bacteriophage endolysins that destroy the bacterial cell wall and liberate new virions. Endolysins have emerged as high-scope antimicrobial agents, especially...
Flaviviruses proteases [0.03%]
黄病毒科蛋白酶
Lorenzo Zammarchi,Flavia Chechi,Michele Spinicci et al.
Lorenzo Zammarchi et al.
West Nile virus (WNV), Zika virus (ZIKV), and Dengue virus (DENV) are vector-borne diseases endemic in tropical and subtropical countries around the world. Their incidence has been growing in recent years and they are becoming increasingly ...
Ahmed E Elsawi,Haytham O Tawfik,Wagdy M Eldehna
Ahmed E Elsawi
The multipurpose enzyme papain-like protease (PLpro) is crucial for both immune evasion and viral multiplication. The replication-transcription complex is formed when PLpro, encoded by nonstructural protein 3 (nsp3), cleaves the viral polyp...
Viral proteases: Structural basis of function, evolution, and drug design [0.03%]
病毒蛋白酶：功能、进化和药物设计的结构基础
Luigi Franklin Di Costanzo
Luigi Franklin Di Costanzo
Viral proteases are essential enzymes that orchestrate the maturation of viral polyproteins, a critical step in infectious viral particles. Understanding their structure and function is paramount for developing effective antiviral therapies...
Claudiu T Supuran,Clemente Capasso
Claudiu T Supuran
The SARS-CoV-2 main protease (Mpro) plays a pivotal role in the viral life cycle by cleaving polyproteins pp1a and pp1ab into functional non-structural proteins (NSPs), including components essential for RNA replication, such as nsp7, nsp8,...
Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies [0.03%]
丙型肝炎病毒(HCV)蛋白酶：结构、功能和抑制策略
Pedro Henrique Oliveira Borges,Emmanuel Gras,Sabrina Baptista Ferreira et al.
Pedro Henrique Oliveira Borges et al.
Hepatitis C virus (HCV) is a bloodborne, hepatotropic RNA virus and a serious global health burden, infecting over 50 million people worldwide, with the majority residing in low- and middle-income countries (LMICs), that significantly contr...
Stefano Rusconi,Niccolò Paoletti,Claudiu T Supuran
Stefano Rusconi
The HIV protease (HPR) is a virus-specific aspartic protease responsible for processing the polyproteins of gag and gag-pol during virion maturation and for the proliferation of HIV. The activity of HPR is essential for virus infectivity, t...