F Richard,H Filali,V De Brouwere
F Richard
C Rogier,T Fusaï,B Pradines et al.
C Rogier et al.
There are no specific clinical signs or symptoms of malaria. Fever attacks, anemia, or signs of severity like coma or respiratory distress cannot easily be attributed to malaria in people who are infected most of the time. Ascribing clinica...
M Cot
M Cot
Malaria still remains one of the main public health problems in the world. In spite of early and numerous clinical trials, the situation seems to have been worsening in the last ten years. Malaria clinical research involves several levels: ...
D Fontenille,A Cohuet,P Awono-Ambene et al.
D Fontenille et al.
Only about 60 Anopheline species transmit malaria among more than 3,000 mosquito species recorded in the world. In Africa, the major vectors are Anopheles gambiae,An. arabiensis, An. funestus, An. nili and An. moucheti. They all belong to s...
[Molecular biology in clinical cancer research: the example of digestive cancers] [0.03%]
[分子生物学在临床癌症研究中的应用——以消化系统肿瘤为例]
A Lièvre,P Laurent-Puig
A Lièvre
Cancer is a DNA disease characterized by uncontrolled cell proliferation due to the accumulation of genetic alterations. Recent progress in molecular biology allowed the identification of markers potentially usefull for patients management ...
Somatic mutations in human cancer: applications in molecular epidemiology [0.03%]
人类癌症中的体细胞突变及其在分子流行病学中的应用
E Le Roux,E Gormally,P Hainaut
E Le Roux
The tumour suppressor protein p53 mediates cell-cycle arrest, DNA repair and apoptosis after activation by multiple forms of cellular stresses. When activated, this "master protein" modulates its response depending on the type and intensity...
[Market and ageing] [0.03%]
[市场与老龄化]
M-E Joël
M-E Joël
Ageing can be defined as growth of the proportion of elderly people in the population, but also as a group of transformations in life cycles: older age at time of first job, marriage, birth of first child, early retirement, longer life expe...
[Methodological problems in clinical and epidemiological research on ageing] [0.03%]
[老年临床和流行病学研究中的方法学问题]
J-F Dartigues
J-F Dartigues
A lot of methological difficulties interfere with the design and the interpretation of data analysis in clinical and epidemiological research on diseases related to ageing. The first one is that normal and pathological ageing are often stro...
L Kappeler,J Epelbaum
L Kappeler
Despite very different life expectancies, a 2-year-old mouse, a 12-year-old dog, a 32-year-old chimpanzee or an 80-year-old man will share many common deficits such as a reduction in tissue elasticity, immunological responses, muscular stre...