PROBES FOR NARCOTIC RECEPTOR MEDIATED PHENOMENA. 38. AN EXPEDITIOUS SYNTHESIS OF RAC-CIS-4a-ETHYL-2-METHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYRIDIN-6-OL AND RAC-CIS-2-METHYL-4a-PHENETHYL-1,2,3,4,4a,9a-HEXAHYDROBENZOFURO[2,3-c]PYRIDIN-6-OL [0.03%]
阿片受体介导现象探针的高效合成：顺-4a-乙基-2-甲基-1，2，3，4，4a，9a-六氢苯并呋喃并吡啶和顺-2-甲基-4a-phenethyl-1，2，3，4，4a，9a-六氢苯并呋喃并[2，3-c]吡啶的对映体混合物
Malliga R Iyer,Jeffrey R Deschamps,Arthur E Jacobson et al.
Malliga R Iyer et al.
A high-yielding five-step synthesis of cis-benzofuropyridin-6-ols provided an improved route to compounds with low to subnanomolar affinity at opioid receptors and high antinociceptive potency. This synthesis provided the known rac-cis-4a-e...
REGIOSELECTIVE SYNTHESIS OF EITHER 1H- OR 2H-1,2,3- TRIAZOLES VIA MICHAEL ADDITION TO α,ß-UNSATURATED KETONES [0.03%]
α,β-不饱和酮的迈克尔加成选择性合成1h-或2h-1,2,3-三唑
Sen Wai Kwok,Jason E Hein,Valery V Fokin et al.
Sen Wai Kwok et al.
The Michael reaction of NH-1,2,3-triazole (1) with α,β-unsaturated ketones was studied. 1H-1,2,3-triazolyl-ketones were selectively generated when 1 was combined neat with a variety of enones. The use of aprotic solvents with catalytic ba...
SUBTLE CONTROL IN SOLUTION AND CRYSTAL STRUCTURES WITH WEAK HYDROGEN BONDS: THE UNUSUAL PROFILE OF DIMETHYL 3, 12-DIOXO-7, 8 DITHIA 4, 11-DIAZABICYCLO[12.2.2]OCTADECA-1(16), 14, 17-TRIENE 5, 10-DICARBOXYLATE (TDA1) [0.03%]
溶液和晶体结构中的弱氢键对二甲基3,12-二氧杂-7,8-硫杂-4,11-氮杂双环[12.2.2]十八-1(16),14,17-三烯-5,10-二羧酸酯(TDA1)的微妙调控: 不同寻常的谱图
Isabella L Karle,Lulu Huang,Punna Venkateshwarlu et al.
Isabella L Karle et al.
The structural features of the title compound were determined or examined by three diverse procedures: single crystal X-ray diffraction analysis, solution spectroscopic procedures and Quantum mechanical theoretical calculations. The conform...
Wei Wang,Carl R Yamnitz,George W Gokel
Wei Wang
A family of hydraphile ionophores has been prepared in which various approximately CH(2)N approximately to approximately CON approximately replacements have been made to assess the effect on Na(+) transport through phospholipid bilayers. Wh...
ENANTIOMERIC SYNTHESIS OF 2-C-METHYL-D-ERYTHRITOL 2, 4-CYCLODIPHOSPHATE [0.03%]
2-C-甲基-D赤藓糖醇2，4-环化焦磷酸的对映选择性合成
Prabagaran Narayanasamy,Dean C Crick
Prabagaran Narayanasamy
Enantiomerically pure 2-C-methyl-D-erythritol 2,4-cyclodiphosphate 1 (ME-CPP) is synthesized from 1,2-O-isopropylidene-α-D-xylofuranose with facile phosphorylation in good yield. Subsequently, the synthesized enantiomerically pure 1 can be...
EVALUATION OF STRATEGIES FOR THE SYNTHESIS OF THE GUANIDINE HEMIAMINAL PORTION OF PALAU'AMINE [0.03%]
用于合成帕拉乌胺的瓜尔idine半胺亚基的策略评估
Brian A Lanman,Larry E Overman
Brian A Lanman
Potential methods for the generation of the guanidine hemiaminal functionality of palau'mine (1) from a spirocyclic thiohydantoin precursor are examined using a spirobicyclic model system, culminating in the identification of an efficient m...
SYNTHESIS AND SPECTROSCOPIC DIFFERENTIATION OF 2- AND 4-ALKOXYTHIOTETRONIC ACIDS [0.03%]
2-和4-烷氧基噻吩并四氢吡喃并环丁烷-1,3-二酮的合成及光谱区分研究
Gautham Shenoy,Pilho Kim,Michael Goodwin et al.
Gautham Shenoy et al.
O-Alkylation of thiotetronic acids gives a mixture of 2- and 4-position enol ether products. Comparison of the physical data revealed that UV spectroscopy was the most reliable method of distinguishing between these related ethers. We have ...