REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES [0.03%]
区域选择性多功能串联反应可快速高效地制备嵌套稠合吖啶骨架化合物
Jin-Peng Zhang,Wei Fan,Jie Ding et al.
Jin-Peng Zhang et al.
Regioselective three-component reactions of aromatic aldehydes with indazol-5-amine and 2-hydroxy-1,4-naphthoquinone in HOAc under microwave irradiation have been developed. In this one-pot reaction, a series of new pyrazole-fused benzo[h]a...
CYCLOADDITION REACTIONS OF AZIDE, FURAN, AND PYRROLE UNITS WITH BENZYNES GENERATED BY THE HEXADEHYDRO-DIELS-ALDER (HDDA) REACTION [0.03%]
由己六烯稀基二氢化-diels-alder反应生成的联苯炔与叠氮化物、呋喃和吡咯单元的环加成反应
Junhua Chen,Beeraiah Baire,Thomas R Hoye
Junhua Chen
Benzynes can be generated by the intramolecular thermal cycloisomerization of triynes-the title HDDA reaction. We report here that these can be trapped by cycloaddition reaction with trimethylsilyl azide (1,3-dipolar) or a furan or pyrrole ...
FORMAL SYNTHESIS OF HAPALINDOLE O AND SYNTHETIC EFFORTS TOWARDS HAPALINDOLE K AND AMBIGUINE A [0.03%]
哈帕灵丁醇碱O的全合成及哈帕灵丁醇K和氨双乌药灵A的合成研究
Ryan J Rafferty,Robert M Williams
Ryan J Rafferty
The formal synthesis of D,L-hapalindole O has been accomplished intercepting Natsume's total synthesis route. The intercepted substrate was synthesized in an overall 36% yield over ten-synthetic steps compared to Natsume's overall 1% yield ...
SYNTHESIS OF DE NOVO CHIRAL γ-AMINO-YNAMIDES USING LITHIATED YNAMIDES. OBSERVATION OF A UNIQUE 5- ENDO-DIG CYCLIZATION WITH AN INVERSION OF S-CENTER [0.03%]
利用锂化炔胺合成新型手性γ-氨基炔胺：S中心翻转的独特五元内环化反应观测报告
Xiao-Na Wang,Richard P Hsung,Sierra K Fox et al.
Xiao-Na Wang et al.
We describe herein details of our efforts in developing a highly stereoselective synthesis of de novo chiral γ-amino-ynamides through additions of lithiated ynamides to Ellman-Davis chiral N-tert-butanesulfinyl imines. While additions of y...
SUZUKI-MIYAURA COUPLING REACTIONS OF 3,5-DICHLORO-1,2,4-THIADIAZOLE [0.03%]
3,5-二氯-1,2,4-噻二唑的SUZUKI-MIYAURA偶联反应
Abdelbasset A Farahat,David W Boykin
Abdelbasset A Farahat
3,5-Dichloro-1,2,4-thiadiazole was allowed to react with different arylboronic acids under different Suzuki-Miyaura coupling conditions: at room temperature 5-aryl-3-chloro-1,2,4-thiadiazoles were obtained and at toluene reflux temperature ...
A NEW APPROACH TO THE SYNTHESIS OF SUBSTITUTED PHENAZINES VIA PALLADIUM-CATALYZED ARYL LIGATIONi [0.03%]
一种合成取代茋衍生物的新方法：钯催化芳基化串联策略构建苯并菲骨架
Jeffrey D Winkler,Barry M Twenter,Thomas Gendrineau
Jeffrey D Winkler
A new method for the "ligation" of two aromatic rings has been achieved via synthesis of functionalized phenazines by double Buchwald-Hartwig cyclization of a variety of substituted bromoanilines.
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 2: Routes to Bicyclic Sultams [0.03%]
1,5,2-二噻氮杂戊烷1,1-二氧化物化合物库的合成（二）：双环磺酰胺的合成路线
Qin Zang,Salim Javed,Aihua Zhou et al.
Qin Zang et al.
The synthesis of a library of bicyclic sultams incorporating the 1,5,2-dithiazepine 1,1-dioxide moiety is reported. Following scaffold synthesis via a one-pot sulfonylation/intramolecular thia-Michael protocol, several additional cyclizatio...
Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol [0.03%]
1,5,2-二噻氮杂戊环1,1-二氧化物类化合物的库合成（第一部分）：一步砜化/硫代迈克尔加成协议
Qin Zang,Aihua Zhou,Salim Javed et al.
Qin Zang et al.
A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, followed by in s...
Wen-Hui Xu,Melissa R Jacob,Ameeta K Agarwal et al.
Wen-Hui Xu et al.
Phytochemical investigation of the native American plant Gaura longiflora led to the isolation of three new and eight known flavonol glycosides. The structures of the new compounds were established primarily by spectroscopic data as quercet...
SYNTHETIC STUDIES ON MPC1001: A DIPOLAR CYCLOADDITION APPROACH TO THE PYRROLIDINE RING SYSTEM [0.03%]
基于二𫫇环加成的MPC1001合成研究——构筑吡咯烷类片段的新方法
Paul T Schuber,Robert M Williams
Paul T Schuber
A novel [1,3]-dipolar azomethine ylide cycloaddition has been developed in an approach to the synthesis of the MPC1001 family of natural products.