W W Downie
W W Downie
In patients with underlying renal impairment, administration of nonsteroidal anti-inflammatory drugs (NSAID) can produce a marked reduction of renal function via inhibition of renal prostaglandin (PG) synthesis. Recent findings indicate tha...
Prevalence of mucosal lesions in the stomach and duodenum due to chronic use of NSAID in patients with rheumatoid arthritis or osteoarthritis, and interim report on prevention by misoprostol of diclofenac associated lesions [0.03%]
NSAID所致慢性胃肠道损害的流行病学及米索前列醇预防双氯芬酸致溃疡的中间期报告
G S Geis,H Stead,C B Wallemark et al.
G S Geis et al.
We review preliminary findings of the screening and prophylaxis phases of a study of misoprostol in patients with arthritis receiving nonsteroidal antiinflammatory drugs (NSAID). Endoscopic evaluation of over 1,800 patients with rheumatoid ...
S D Shapiro,E J Campbell,R M Senior et al.
S D Shapiro et al.
Human mononuclear phagocytes express an array of serine and metal dependent proteinases that are under complex developmental control and are also highly regulated by physiologic and pharmacologic stimuli. Monocytes contain the intracellular...
J A Hamilton,P H Hart,T Leizer et al.
J A Hamilton et al.
The plasminogen activator (PA)/plasmin system has been implicated in the inflammation and connective tissue remodelling occurring in arthritic joints. PA activity is detected in cultures of human monocytes, synoviocytes and chondrocytes and...
C Homer,S T Shulman
C Homer
We review the epidemiology and clinical features of recent outbreaks of acute rheumatic fever. The history of this disorder as well as current management practices are also discussed.
J F Woessner Jr,Z Gunja-Smith
J F Woessner Jr
Extracts of human articular cartilage have been examined for the presence of metalloproteinases that degrade proteoglycans and collagen of the extracellular matrix. Two enzymes (stromelysin and acid metalloproteinase) that degrade proteogly...
Increased collagenase activity in metastatic cells as a result of decreased TIMP expression [0.03%]
金属基质素表达减少所致转移细胞胶原酶活性增加
D Skup,A Ponton
D Skup
It has been postulated in a number of systems that increased metalloproteinase activity in different pathologies can be due to decreased levels of the specific inhibitor tissue inhibitor of metalloproteinases (TIMP). To date direct proof of...
In vitro effects of interleukin 1 on the synthesis of metalloproteases, TIMP, plasminogen activators and inhibitors in human articular cartilage [0.03%]
白细胞介素1对人关节软骨合成金属基质溶解酶、TIMP、尿激酶及抑制因子的体外影响研究
J Martel-Pelletier,M Zafarullah,S Kodama et al.
J Martel-Pelletier et al.
Degradation of cartilage matrix macromolecules depends on the increase of metalloprotease activity. It has been suggested that interleukin 1 (IL-1) contributes to cartilage break-down by modulating the synthesis of the elements favoring an ...
Chondrocyte mediated cartilage degradation: regulation by prostaglandin E2, cyclic AMP and interferon alpha [0.03%]
软骨细胞介导的软骨降解：由前列腺素E2、环AMP和干扰素α调节
J J Steinberg,C B Sledge
J J Steinberg
Local responses to cytokines and their induced products play a critical role in outcome in the arthritic joint. Using a bovine nasal cartilage culture model, chondrocyte mediated breakdown was stimulated by lipopolysaccharides or tumor necr...
G Lust,N Burton-Wurster,H Leipold et al.
G Lust et al.
Synthesis of fibronectin and proteoglycan by chondrocytes in both cell and organ culture was affected by the culture conditions. Less than 2% of the fibronectin extracted from cartilage contained the ED-III-A sequence, however, chondrocytes...