Challenging the pyramid. A new look at terapeutic approaches for rheumatoid arthritis. Patient selection [0.03%]
挑战金字塔：类风湿性关节炎治疗的新视角：患者选择
W A Katz
W A Katz
The goals of therapy for rheumatoid arthritis (RA) address alleviation of pain; prevention of joint destruction, deformity, and disability; and maintenance of life style. Disease modifying antirheumatic drugs (DMARD) are among the most impo...
I A Jaffe
I A Jaffe
Currently available therapeutic agents for the treatment of rheumatoid arthritis are unsatisfactory for many patients, due either to inefficacy, loss of effectiveness with time, or toxicity. One approach is to study drugs in combination, at...
Challenging the pyramid. A new look at therapeutic approaches for rheumatoid arthritis. Earlier intervention with second line therapies [0.03%]
挑战金字塔：类风湿关节炎治疗的新视角：早期使用二线药物疗法
J R Ward
J R Ward
It is clear that nonsteroidal antiinflammatory drugs (NSAID) may help control the pain and swelling of rheumatoid arthritis (RA) but do not retard joint destruction. Similarly, prednisone is effective in controlling pain and swelling but it...
Options in the treatment and prevention of NSAID-induced gastroduodenal mucosal damage [0.03%]
非甾体抗炎药所致胃肠道粘膜损害的防治方法的选择
N M Agrawal,E Z Dajani
N M Agrawal
Aspirin and other nonsteroidal antiinflammatory drugs (NSAID) have been associated with various degrees of gastroduodenal damage. The agents currently available for the treatment of gastric mucosal damage caused by NSAID are histamine2-rece...
E M Ayoub,E Kaplan
E M Ayoub
Recent investigation has delineated some of the bacterial and host factors that may play a role in the pathogenesis of rheumatic fever. Continuing studies support the role of antibodies to crossreactive antigens in human tissues and the gro...
The genetics of rheumatic fever: relationship to streptococcal infection and autoimmune disease [0.03%]
风湿热的遗传学：与链球菌感染和自身免疫疾病的关系
A Gibofsky,A Khanna,E Suh et al.
A Gibofsky et al.
A large body of evidence suggests that patients with rheumatic fever immunologically respond abnormally both at a humoral and cellular level to streptococcal antigens cross-reactive with mammalian tissues. Implicit in this concept is that t...
Cartilage maintenance in osteoarthritis: interaction of cytokines, NSAID and prostaglandins in articular cartilage damage and repair [0.03%]
软骨在骨关节炎中的维持：细胞因子、非甾体抗炎药和前列腺素在关节软骨损伤及修复过程中的交互作用
J T Dingle
J T Dingle
The structural integrity of the matrix of human articular cartilage is maintained by a dynamic equilibrium between synthesis and degradation. In osteoarthritis (OA), synthesis may be inhibited by the presence of subnanogram quantities of th...
Are prostaglandins proinflammatory, antiinflammatory, both or neither? [0.03%]
前列腺素是促炎的、抗炎的、还是两者兼而有之？
J S Goodwin
J S Goodwin
Research on the role of prostaglandins (PG) in inflammation has been divided along 2 lines of inquiry. One supposes that PG are proinflammatory, explaining why nonsteroidal antiinflammatory drugs (NSAID), which prevent conversion of arachid...
R D Toto
R D Toto
Renal prostaglandins (PG) play an important role in regulating renal hemodynamics and excretory function in 2 conditions (1) which effective arterial blood volume is reduced and (2) chronic renal failure is reduced. The use of nonsteroidal ...