Quantitative microfocal radiographic assessment of disease and progression in osteoarthritis of the hand [0.03%]
手骨关节炎疾病及发展变化的定量微观放射成像评估方法研究
C Buckland-Wright,D Macfarlane,J Lynch
C Buckland-Wright
Macroradiographic examination of the wrists and hands of 32 patients with osteoarthritis (OA) over an 18 month period showed that, compared with healthy control subjects, 44% of the patients had significant joint space narrowing at entry, w...
M C Hochberg
M C Hochberg
Osteoarthritis (OA) is the most common of the arthropathies. Previous epidemiologic studies have described the prevalence of OA by age, gender and site in many populations. Cross sectional and retrospective data from these prevalence survey...
T D Spector,D J Hart,E C Huskisson
T D Spector
Conventional radiographic grading of the knee has been used for 30 years and is based around the presence of osteophytes. About 50% of subjects from the general population meeting traditional radiographic criteria are asymptomatic or have n...
W Martel,R S Adler,K Chan et al.
W Martel et al.
The new imaging modalities, namely computed tomography (CT), magnetic resonance imaging (MRI), and ultrasonography (US) provide potentially powerful tools for in vivo assessment of osteoarthritis (OA), monitoring the progress of the disease...
R S Fife
R S Fife
Subunits of a disulfide bonded 550,000 Da cartilage matrix glycoprotein have been detected in the serum of dogs with osteoarthritis (OA) produced by anterior cruciate ligament transection of one hind limb. Cartilage matrix glycoprotein also...
D Heinegård,T Saxne
D Heinegård
Cartilage contains a number of matrix macromolecules not present in other connective tissues. In tissue processes in disease and in normal turnover of the matrix these molecules are fragmented and released into surrounding fluids, in the ca...
Circulating keratan sulfate: a marker of cartilage proteoglycan catabolism in osteoarthritis [0.03%]
循环中的岩藻糖硫酸盐：骨关节炎软骨蛋白聚糖分解的标志物
E J Thonar,D M Manicourt,J Williams et al.
E J Thonar et al.
The serum level of a highly sulfated epitope present on long keratan sulfate chains provides a direct measure of the rate of catabolism of cartilage proteoglycans. Levels of the keratan sulfate epitope are elevated in patients with generali...
J G Peyron
J G Peyron
Since most of the pathophysiological steps of the initiation of osteoarthritis are not understood, its prevention can only mean decreasing or abolishing its risk factors. Excess mechanical stresses certainly can be minimized by correcting d...
M G Lequesne,M Samson
M G Lequesne
Indices of severity for hip and knee diseases may be applied to any disabling disease of these joints, but were especially designed and validated for osteoarthritis (OA). With experience, a score could be obtained in 3-4 minutes and the rep...
Clinical Trial
The Journal of rheumatology. Supplement. 1991 Feb:27:16-8. DOI: 1991
R W Moskowitz,B Boja,C W Denko
R W Moskowitz
It is postulated that osteoarthritis (OA) is associated with an imbalance between cytokine related cartilage degradation, and maintenance of proliferative and synthetic cell responses related to growth factor activity. Insulin, insulin-like...