Chronic inflammatory joint diseases: natural inhibitors of interleukin 1 and tumor necrosis factor alpha [0.03%]
慢性炎性关节病：白细胞介素1和肿瘤坏死因子α的天然抑制剂
J M Dayer
J M Dayer
Cytokines play a major role in the initiation of the immune response or acute inflammatory events, and in the transition to or persistence of chronic inflammation, which eventually lead to tissue destruction and/or fibrosis. Cytokine inhibi...
Effects of hormones and local growth factors on articular chondrocyte metabolism [0.03%]
激素和局部生长因子对关节软骨细胞代谢的影响
P Franchimont,C Bassleer
P Franchimont
Human chondrocyte proliferation and production of matrix components such as proteoglycans and type II collagen (coll. II) were studied in an in vitro model of differentiated chondrocytes. It clearly appears that several hormones such as gro...
H J Mankin,L C Jennings,B V Treadwell et al.
H J Mankin et al.
Studies of articular cartilage over the decades have demonstrated a surprisingly brisk rate of synthesis of the matrix proteins which appears to vary considerably with metabolic, physicochemical and pathological state of the tissue. It has ...
Changes in proteoglycans in osteoarthritis: biochemistry, ultrastructure and biosynthetic processing [0.03%]
骨关节炎中的蛋白聚糖变化：生物化学、超微结构和生物合成加工
C J Malemud
C J Malemud
The loss of proteoglycans from articular cartilage is a hallmark of the osteoarthritic process. Compensatory biosynthesis of proteoglycans is evident by histochemical analysis, characterized by significant metachromasy in the pericellular r...
Measurement of proteoglycan mRNA in articular cartilage--preliminary investigations [0.03%]
关节软骨中蛋白多糖mRNA的测定初步研究报告
M E Adams,D Q Huang
M E Adams
Measurement of mRNA in adult articular cartilage could define whether treatment with nonsteroidal antiinflammatory drugs affects the rate of proteoglycan synthesis in vivo in osteoarthritis. We studied a variety of extraction and isolation ...
P J Roughley,Q Nguyen,J S Mort
P J Roughley
Aging of human articular cartilage is associated with proteolytic degradation of its constituent proteoglycan aggregates. Similar events are thought to be associated with proteoglycan loss in osteoarthritis. Degradative changes in link prot...
D R Eyre,J J Wu,P E Woods
D R Eyre
The molecular sites of crosslinking between types II and IX collagens of bovine articular cartilage have been defined. All 3 chains of the type IX molecule, alpha 1 (IX), alpha 2 (IX) and alpha 3 (IX), contain an hydroxylysine close to the ...
K E Kuettner,M B Aydelotte,E J Thonar
K E Kuettner
The ability of articular cartilage to undergo reversible deformation is dependent upon the organization of specific macromolecules within the extracellular matrix. This abundant matrix is elaborated by a small number of chondrocytes which m...
Early bone changes in experimental osteoarthritis using microscopic computed tomography [0.03%]
实验性骨关节炎的早期骨改变的微观CT研究
D K Dedrick,R Goulet,L Huston et al.
D K Dedrick et al.
Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in ca...
Magnetic resonance imaging reflects the chemical changes of aging degeneration in the human intervertebral disk [0.03%]
磁共振成像反映人体椎间盘老化变性的化学变化
R H Pearce,J P Thompson,G M Bebault et al.
R H Pearce et al.
T2 weighed spin echo magnetic resonance images (MRI) of the intervertebral disks of 4 lumbar spines were graded and the nuclei pulposi were analyzed for water, collagen and proteoglycan. The brightness of the nuclear image correlated direct...