Diagnosis of latent tuberculosis and prevention of reactivation in rheumatic patients receiving biologic therapy: international recommendations [0.03%]
风湿病生物制剂治疗患者的潜伏结核感染诊断及预防国际推荐意见
Florenzo Iannone,Fabrizio Cantini,Giovanni Lapadula
Florenzo Iannone
Objective: To review the official international recommendations on the management of latent tuberculosis infection (LTBI) in patients with rheumatic diseases undergoing biologic therapy. ...
Diagnostic accuracy of chest radiography for the diagnosis of tuberculosis (TB) and its role in the detection of latent TB infection: a systematic review [0.03%]
胸部X线摄影诊断结核病的准确性及其在检测潜伏性结核感染中的作用：系统评价
Riccardo Piccazzo,Francesco Paparo,Giacomo Garlaschi
Riccardo Piccazzo
In this systematic review we evaluate the role of chest radiography (CXR) in the diagnostic flow chart for tuberculosis (TB) infection, focusing on latent TB infection (LTBI) in patients requiring medical treatment with biological drugs. In...
Performance of the tuberculin skin test and interferon-γ release assays: an update on the accuracy, cutoff stratification, and new potential immune-based approaches [0.03%]
结核菌素皮肤试验和干扰素-γ释放实验的性能：准确性、临界值分层及潜在免疫学方法更新研究进展
Delia Goletti,Alessandro Sanduzzi,Giovanni Delogu
Delia Goletti
An association between biologic agents and reactivation of active disease from latent tuberculosis infection (LTBI) has been established. Screening for LTBI is, therefore, now recommended for candidates for biologic drugs. The tuberculin sk...
Cellular and humoral immune responses during tuberculosis infection: useful knowledge in the era of biological agents [0.03%]
免疫细胞和体液在结核病感染期间的反应：生物制剂时代有用的知识
Andrea Matucci,Enrico Maggi,Alessandra Vultaggio
Andrea Matucci
In this review, recent insights into innate and adaptive cellular and humoral immune response to Mycobacterium tuberculosis (Mtb) are discussed and the role of specific cytokines such as tumor necrosis factor-α (TNF-α) is highlighted. Acc...
The spectrum of tuberculosis infection: new perspectives in the era of biologics [0.03%]
结核感染的谱系：生物制剂时代的全新视角
Giovanni Delogu,Delia Goletti
Giovanni Delogu
The risk of developing active tuberculosis (TB) is higher in patients taking immunosuppressive drugs, either as a result of reactivation of a latent TB infection (LTBI) or following a new infection with Mycobacterium tuberculosis (Mtb). We ...
Michele Conversano
Michele Conversano
As in many countries in Western Europe, in Italy tuberculosis (TB) is a relatively rare disease. In the last decade its incidence has remained constant at under 10 cases/100,000 inhabitants, the threshold considered to define a country as l...
Biologics and tuberculosis risk: the rise and fall of an old disease and its new resurgence [0.03%]
生物制剂与结核病风险：一种老疾病的新起与衰退及其再次流行
Fabrizio Cantini,Delia Goletti
Fabrizio Cantini
Pain pharmacotherapy in patients with inflammatory arthritis and concurrent cardiovascular or renal disease: a Cochrane systematic review [0.03%]
类风湿性关节炎患者并发心血管或肾病的止痛药治疗：一项Cochrane系统综述研究
Jonathan L Marks,Désirée M van der Heijde,Alexandra N Colebatch et al.
Jonathan L Marks et al.
Background: Pain in inflammatory arthritis (IA) is common and often multifactorial, and many different pharmacotherapeutic agents are routinely used for pain management. There are concerns that some current pain pharmacot...
How do gastrointestinal or liver comorbidities influence the choice of pain treatment in inflammatory arthritis? A Cochrane systematic review [0.03%]
胃肠或肝脏的合并症如何影响炎症性关节炎疼痛治疗的选择？一项Cochrane系统综述
Helga Radner,Sofia Ramiro,Désirée M van der Heijde et al.
Helga Radner et al.
Objective: To assess efficacy and safety of pharmacological pain treatment in patients with inflammatory arthritis (IA) and gastrointestinal (GI) or liver comorbidities. ...