Solute Carrier Transportome in Chemotherapy-Induced Adverse Drug Reactions [0.03%]
化疗诱导的药物不良反应的溶质载体转运组学研究
Jason T Anderson,Kevin M Huang,Maryam B Lustberg et al.
Jason T Anderson et al.
Members of the solute carrier (SLC) family of transporters are responsible for the cellular influx of a broad range of endogenous compounds and xenobiotics. These proteins are highly expressed in the gastrointestinal tract and eliminating o...
Anna A Kiseleva,Anna S Nikonova,Erica A Golemis
Anna A Kiseleva
Among the factors that have been strongly implicated in regulating cancerous transformation, the primary monocilium (cilium) has gained increasing attention. The cilium is a small organelle extending from the plasma membrane, which provides...
Yu-Kai Chao,Sui-Yuan Chang,Christian Grimm
Yu-Kai Chao
Among the infectious diseases caused by pathogenic microorganisms such as bacteria, viruses, parasites, or fungi, the most prevalent ones today are malaria, tuberculosis, influenza, HIV/AIDS, Ebola, dengue fever, and methicillin-resistant S...
Hari Prasad,Rajini Rao
Hari Prasad
Neurodegenerative disorders are debilitating and largely untreatable conditions that pose a significant burden to affected individuals and caregivers. Overwhelming evidence supports a crucial preclinical role for endosomal dysfunction as an...
Ion Channel Profiling in Prostate Cancer: Toward Cell Population-Specific Screening [0.03%]
前列腺癌中的离子通道分析：面向细胞群特定筛查
Valerio Farfariello,Natalia Prevarskaya,Dimitra Gkika
Valerio Farfariello
In the last three decades, a growing number of studies have implicated ion channels in all essential processes of prostate carcinogenesis, including cell proliferation, apoptosis, migration, and angiogenesis. The changes in the expression o...
How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression [0.03%]
肿瘤微环境与离子转运蛋白之间的相互作用如何推动癌症进展
Line O Elingaard-Larsen,Michala G Rolver,Ester E Sørensen et al.
Line O Elingaard-Larsen et al.
Solid tumors comprise two major components: the cancer cells and the tumor stroma. The stroma is a mixture of cellular and acellular components including fibroblasts, mesenchymal and cancer stem cells, endothelial cells, immune cells, extra...
Ines Böhme,Roland Schönherr,Jürgen Eberle et al.
Ines Böhme et al.
Recent research has revealed that ion channels and transporters can be important players in tumor development, progression, and therapy resistance in melanoma. For example, members of the ABC family were shown to support cancer stemness-lik...
Bastian Roth,Stephan M Huber
Bastian Roth
Neoplastic transformation is associated with alterations of the ion transports across plasma and intracellular membranes. These alterations are crucial elements of the phenotypical reprogramming of the transformed cells and may promote adap...
Ana Ramírez,Janice García-Quiroz,Luis Aguilar-Eslava et al.
Ana Ramírez et al.
The expression and function of many ion channels and transporters in cancer cells display major differences in comparison to those from healthy cells. These differences provide the cancer cells with advantages for tumor development. Accordi...
Anne Steglich,Linda Hickmann,Andreas Linkermann et al.
Anne Steglich et al.
The juxtaglomerular renin-producing cells (RPC) of the kidney are referred to as the major source of circulating renin. Renin is the limiting factor in renin-angiotensin system (RAS), which represents a proteolytic cascade in blood plasma t...