Dalila Mango,Robert Nisticò
Dalila Mango
Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neuro...
Ion Channel Dysregulation in Head and Neck Cancers: Perspectives for Clinical Application [0.03%]
头颈癌中的离子通道失调：临床应用的前景
Nagore Del-Río-Ibisate,Rocío Granda-Díaz,Juan P Rodrigo et al.
Nagore Del-Río-Ibisate et al.
Head and neck cancers are a highly complex and heterogeneous group of malignancies that involve very diverse anatomical structures and distinct aetiological factors, treatments and clinical outcomes. Among them, head and neck squamous cell ...
Promising Anti-atherosclerotic Effect of Berberine: Evidence from In Vitro, In Vivo, and Clinical Studies [0.03%]
黄连解热成分的抗动脉粥样硬化作用：体外、体内和临床研究证据
Alireza Fatahian,Saeed Mohammadian Haftcheshmeh,Sara Azhdari et al.
Alireza Fatahian et al.
Elevated levels of plasma cholesterol, impaired vascular wall, and presence of inflammatory macrophages are important atherogenic risk factors contributing to atherosclerotic plaque formation and progression. The interventions modulating th...
Role of pH Regulatory Proteins and Dysregulation of pH in Prostate Cancer [0.03%]
前列腺癌中pH调节蛋白的作用及pH失调
Larry Fliegel
Larry Fliegel
Prostate cancer is the fourth most commonly diagnosed cancer, and although it is often a slow-growing malignancy, it is the second leading cause of cancer-associated deaths in men and the first in Europe and North America. In many forms of ...
Ion Channels in Lung Cancer [0.03%]
肺癌中的离子通道
Etmar Bulk,Luca Matteo Todesca,Albrecht Schwab
Etmar Bulk
Ion channels are a major class of membrane proteins that play central roles in signaling within and among cells, as well as in the coupling of extracellular events with cellular responses. Dysregulated ion channel activity plays a causative...
Contribution and Expression of Organic Cation Transporters and Aquaporin Water Channels in Renal Cancer [0.03%]
肾癌中有机阳离子转运蛋白和水通道水道的贡献与表达
Giuliano Ciarimboli,Gerit Theil,Joanna Bialek et al.
Giuliano Ciarimboli et al.
The body homeostasis is maintained mainly by the function of the kidneys, which regulate salt and water balance and excretion of metabolism waste products and xenobiotics. This important renal function is determined by the action of many tr...
Fenglei Wu,Chi Sun,Jianquan Lu
Fenglei Wu
Renal fibrosis is the final pathological process common to any ongoing, chronic kidney injury or maladaptive repair. Renal fibrosis is considered to be closely related to various cell types, such as fibroblasts, myofibroblasts, T cells, and...
Qi Ling,Holger Kalthoff
Qi Ling
Ion channels and transporters (ICT) play important roles in almost all basic cellular processes. During last decades, abundant evidences have been provided that ICT (e.g., Ca2+ and K+ channels) are notable for regulating physiological pancr...
Potassium and Calcium Channel Complexes as Novel Targets for Cancer Research [0.03%]
钾和钙通道复合物作为癌症研究的新靶点
Marie Potier-Cartereau,William Raoul,Gunther Weber et al.
Marie Potier-Cartereau et al.
The intracellular Ca2+ concentration is mainly controlled by Ca2+ channels. These channels form complexes with K+ channels, which function to amplify Ca2+ flux. In cancer cells, voltage-gated/voltage-dependent Ca2+ channels and non-voltage-...
Effects of the Tumor Environment on Ion Channels: Implication for Breast Cancer Progression [0.03%]
肿瘤环境对离子通道的影响：对乳腺癌进展的启示
Halima Ouadid-Ahidouch,Hamid Morjani,Julie Schnipper et al.
Halima Ouadid-Ahidouch et al.
In recent years, it has been shown that breast cancer consists not only of neoplastic cells, but also of significant alterations in the surrounding stroma or tumor microenvironment. These alterations are now recognized as a critical element...