Endolysosomal Disorders Affecting the Proximal Tubule of the Kidney: New Mechanistic Insights and Therapeutics [0.03%]
影响肾脏近端小管的溶酶体疾病：新的机制见解和治疗方法
Beatrice Paola Festa,Marine Berquez,Daniela Nieri et al.
Beatrice Paola Festa et al.
Epithelial cells that line the proximal tubule of the kidney rely on an intertwined ecosystem of vesicular membrane trafficking pathways to ensure the reabsorption of essential nutrients. To function effectively and to achieve homeostasis, ...
Single-Cell Sequencing and Organoids: A Powerful Combination for Modelling Organ Development and Diseases [0.03%]
单细胞测序和类器官：组合模式研究器官发育和疾病
Yuebang Yin,Peng-Yu Liu,Yinghua Shi et al.
Yuebang Yin et al.
The development and function of a particular organ and the pathogenesis of various diseases remain intimately linked to the features of each cell type in the organ. Conventional messenger RNA- or protein-based methodologies often fail to el...
Ligands and Signaling of Mas-Related G Protein-Coupled Receptor-X2 in Mast Cell Activation [0.03%]
MAS相关G蛋白偶联受体X2的配体及其在肥大细胞活化中的信号转导研究进展
Yan-Ni Mi,Na-Na Ping,Yong-Xiao Cao
Yan-Ni Mi
Mas-related G protein-coupled receptor-X2 (MRGPRX2) is known as a novel receptor to activate mast cells (MCs). MRGPRX2 plays a dual role in promoting MC-dependent host defense and immunomodulation and contributing to the pathogenesis of pse...
Immunomodulatory Effects of Curcumin in Rheumatoid Arthritis: Evidence from Molecular Mechanisms to Clinical Outcomes [0.03%]
姜黄素通过分子机制和临床结果在类风湿性关节炎中的免疫调节作用
Saeed Mohammadian Haftcheshmeh,Arezou Khosrojerdi,Ali Aliabadi et al.
Saeed Mohammadian Haftcheshmeh et al.
Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disorder characterized by the destruction of the joint and bone resorption. The production of pro-inflammatory cytokines and chemokines, dysregulated functions of three imp...
Anne-Marie Ellegaard,Peter Bach,Marja Jäättelä
Anne-Marie Ellegaard
Being originally discovered as cellular recycling bins, lysosomes are today recognized as versatile signaling organelles that control a wide range of cellular functions that are essential not only for the well-being of normal cells but also...
Cross-Talk Between the Adenylyl Cyclase/cAMP Pathway and Ca2+ Homeostasis [0.03%]
腺苷酸环化酶/cAMP信号通路与钙稳态的相互作用
Jose Sanchez-Collado,Jose J Lopez,Isaac Jardin et al.
Jose Sanchez-Collado et al.
Cyclic AMP and Ca2+ are the first second or intracellular messengers identified, unveiling the cellular mechanisms activated by a plethora of extracellular signals, including hormones. Cyclic AMP generation is catalyzed by adenylyl cyclases...
Tate MacDonald,Matthew Saurette,Megan R Beggs et al.
Tate MacDonald et al.
Phosphate is a multivalent ion critical for a variety of physiological functions including bone formation, which occurs rapidly in the developing infant. In order to ensure maximal bone mineralization, young animals must maintain a positive...
Lipid Droplets in Cancer [0.03%]
脂滴与癌症
Toni Petan
Toni Petan
Lipid droplets have a unique structure among organelles consisting of a dense hydrophobic core of neutral lipids surrounded by a single layer of phospholipids decorated with various proteins. Often labeled merely as passive fat storage repo...
Potential of Renin-Angiotensin-Aldosterone System Modulations in Diabetic Kidney Disease: Old Players to New Hope! [0.03%]
在糖尿病肾病中调控肾素-血管紧张素-醛固酮系统的作用：从传统方案到新的希望！
Vajir Malek,Sachin V Suryavanshi,Nisha Sharma et al.
Vajir Malek et al.
Due to a tragic increase in the incidences of diabetes globally, diabetic kidney disease (DKD) has emerged as one of the leading causes of end-stage renal diseases (ESRD). Hyperglycaemia-mediated overactivation of the renin-angiotensin-aldo...
Luigi Catacuzzeno,Luigi Sforna,Vincenzo Esposito et al.
Luigi Catacuzzeno et al.
Brain tumors come in many types and differ greatly in outcome. They are classified by the cell of origin (astrocytoma, ependymoma, meningioma, medulloblastoma, glioma), although more recently molecular markers are used in addition to histol...