The Biochemistry and Physiology of A Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies [0.03%]
人类疾病中的ADAM和ADAM-TS的生化与生理学
Deepti Sharma,Nikhlesh K Singh
Deepti Sharma
Metalloproteinases are a group of proteinases that plays a substantial role in extracellular matrix remodeling and its molecular signaling. Among these metalloproteinases, ADAMs (a disintegrin and metalloproteinases) and ADAM-TSs (ADAMs wit...
Mustafa B A Djamgoz
Mustafa B A Djamgoz
Ion transporting proteins (ITPs) comprise a wide range of ion channels, exchangers, pumps and ionotropic receptors many of which are expressed in tumours and contribute dynamically to the different components and stages of the complex cance...
Inherited Ventricular Arrhythmia in Zebrafish: Genetic Models and Phenotyping Tools [0.03%]
斑马鱼的遗传性室性心律失常：遗传模型和表型工具
Ewa Sieliwonczyk,Vladimir V Matchkov,Bert Vandendriessche et al.
Ewa Sieliwonczyk et al.
In the last years, the field of inheritable ventricular arrhythmia disease modelling has changed significantly with a push towards the use of novel cellular cardiomyocyte based models. However, there is a growing need for new in vivo models...
Rubén Estrada-Valencia,María Eduarda de Lima,Aline Colonnello et al.
Rubén Estrada-Valencia et al.
The existence of a formal Endocannabinoid System in C. elegans has been questioned due to data showing the absence of typical cannabinoid receptors in the worm; however, the presence of a full metabolism for endocannabinoids, alternative li...
Ion Channels, Transporters, and Sensors Interact with the Acidic Tumor Microenvironment to Modify Cancer Progression [0.03%]
离子通道、转运体和传感器通过与酸性的肿瘤微环境相互作用来调节癌症的发展进程
Ebbe Boedtkjer
Ebbe Boedtkjer
Solid tumors, including breast carcinomas, are heterogeneous but typically characterized by elevated cellular turnover and metabolism, diffusion limitations based on the complex tumor architecture, and abnormal intra- and extracellular ion ...
Potassium and Chloride Ion Channels in Cancer: A Novel Paradigm for Cancer Therapeutics [0.03%]
钾离子和氯离子通道在癌症中的作用：抗癌治疗的新理念
Umberto Banderali,Luigi Leanza,Najmeh Eskandari et al.
Umberto Banderali et al.
Cancer is a collection of diseases caused by specific changes at the genomic level that support cell proliferation indefinitely. Traditionally, ion channels are known to control a variety of cellular processes including electrical signal ge...
The Placenta as a Target for Alcohol During Pregnancy: The Close Relation with IGFs Signaling Pathway [0.03%]
酒精与胎盘：妊娠期间靶标：与胰岛素样生长因子密切相关的信号转导通路
Irene Martín-Estal,Inma Castilla-Cortázar,Fabiola Castorena-Torres
Irene Martín-Estal
Alcohol is one of the most consumed drugs in the world, even during pregnancy. Its use is a risk factor for developing adverse outcomes, e.g. fetal death, miscarriage, fetal growth restriction, and premature birth, also resulting in fetal a...
Neuronal Nitric Oxide Synthase (nNOS) in Neutrophils: An Insight [0.03%]
中性粒细胞中的神经型一氧化氮合酶(nNOS)的研究进展
Rashmi Saini,Zaffar Azam,Leena Sapra et al.
Rashmi Saini et al.
NO (nitric oxide) is an important regulator of neutrophil functions and has a key role in diverse pathophysiological conditions. NO production by nitric oxide synthases (NOS) is under tight control at transcriptional, translational, and pos...
When Glycosylation Meets Blood Cells: A Glance of the Aberrant Glycosylation in Hematological Malignancies [0.03%]
糖基化异常与血液系统恶性肿瘤的关系探究
Huining Su,Mimi Wang,Xingchen Pang et al.
Huining Su et al.
Among neoplasia-associated epigenetic alterations, changes in cellular glycosylation have recently received attention as a key component of hematological malignancy progression. Alterations in glycosylation appear to not only directly impac...
Role of Histone Deacetylases in Monocyte Function in Health and Chronic Inflammatory Diseases [0.03%]
组蛋白脱乙酰酶在健康状态和慢性炎症疾病中的单核细胞功能的作用
Rosa María Tordera,María Cortés-Erice
Rosa María Tordera
Histone deacetylases (HDACs) are a family of 18 members that participate in the epigenetic regulation of gene expression. In addition to histones, some HDACs also deacetylate transcription factors and specific cytoplasmic proteins.Monocytes...