Gabriel A Aguirre,José Luis González-Guerra,Luis Espinosa et al.
Gabriel A Aguirre et al.
Non-communicable diseases, such as cardiovascular diseases, are the leading cause of mortality worldwide. For this reason, a tremendous effort is being made worldwide to effectively circumvent these afflictions, where insulin-like growth fa...
Jacopo Meldolesi
Jacopo Meldolesi
In the last few years, exciting reports have emerged regarding the role of the two types of neurotrophin receptors, p75NTR and Trks, not only in neurons, where they were discovered, but also in non-neural cells and, especially, in numerous ...
Prasenjit Prasad Saha,Vinaya Vishwanathan,Kondalarao Bankapalli et al.
Prasenjit Prasad Saha et al.
Iron-sulfur (Fe-S) clusters serve as a fundamental inorganic constituent of living cells ranging from bacteria to human. The importance of Fe-S clusters is underscored by their requirement as a co-factor for the functioning of different enz...
Lei-Miao Yin,Ting-Ting Duan,Luis Ulloa et al.
Lei-Miao Yin et al.
Ezrin is a critical structural protein that organizes receptor complexes and orchestrates their signal transduction. In this study, we review the ezrin-meditated regulation of critical receptor complexes, including the epidermal growth fact...
Catechol-O-Methyltransferase (COMT): An Update on Its Role in Cancer, Neurological and Cardiovascular Diseases [0.03%]
儿茶酚-o-甲基转移酶(COMT)在癌症、神经系统和心血管疾病中的作用研究进展
Pedro Bastos,Tiago Gomes,Laura Ribeiro
Pedro Bastos
Catechol-O-methyltransferase (COMT) is an enzyme that catalyses the methylation of catechol substrates, classically in catecholamine metabolism, but also acting upon other substrates such as oestrogen and polyphenols. Although its classical...
Cannabinoids as Modulators of Cell Death: Clinical Applications and Future Directions [0.03%]
细胞死亡调节剂的大麻素：临床应用和未来发展方向
B M Fonseca,N A Teixeira,G Correia-da-Silva
B M Fonseca
Endocannabinoids are bioactive lipids that modulate various physiological processes through G-protein-coupled receptors (CB1 and CB2) and other putative targets. By sharing the activation of the same receptors, some phytocannabinoids and a ...
Origin, Function, and Fate of Metallothionein in Human Blood [0.03%]
人血清金属硫蛋白的起源、功能及代谢 fate/metabolism research paper
Mohammad Tariqur Rahman,Nazmul Haque,Noor Hayaty Abu Kasim et al.
Mohammad Tariqur Rahman et al.
Toxic heavy metals, toxic organic compounds, reactive oxygen species (ROS), infections, and temperature are well-known metallothionein (MT) inducers in human blood. The current review aims to summarize synthesis, function, and fate of human...
Xun Ai,Jiajie Yan,Elena Carrillo et al.
Xun Ai et al.
Stress-response kinases, the mitogen-activated protein kinases (MAPKs) are activated in response to the challenge of a myriad of stressors. c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinases (ERKs), and p38 MAPKs are the ...
Exosomes: From Functions in Host-Pathogen Interactions and Immunity to Diagnostic and Therapeutic Opportunities [0.03%]
外泌体：从宿主与病原微生物的相互作用和免疫到诊断和治疗的机会
Jessica Carrière,Nicolas Barnich,Hang Thi Thu Nguyen
Jessica Carrière
Since their first description in the 1980s, exosomes, small endosomal-derived extracellular vesicles, have been involved in innate and adaptive immunity through modulating immune responses and mediating antigen presentation. Increasing evid...
Christine E Genge,Eric Lin,Ling Lee et al.
Christine E Genge et al.
Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and functional genomics as well as in cardiac structure-function studies. The zebrafish heart has been increasingly used as a model of human cardiac funct...