Colin D McCaig
Colin D McCaig
Since the first Chapter dealt with the well-known charge-charge interactions familiar to biologists, this concluding Chapter introduces some key electrical forces, probably much less familiar, perhaps even unknown. LLPS (liquid liquid phase...
Colin D McCaig
Colin D McCaig
This penultimate chapter is based on a single paper published in Nature in 2022. I have used it specifically as an exemplar, in this case to show that memory improvement in old age may be regulated by a multiplicity of electrical forces. Ho...
Colin D McCaig
Colin D McCaig
ATP synthase is a rotary motor enzyme that drives the formation of ATP from ADP and P and uses multiple electrical forces to do this. This chapter outlines the exquisite use of these electrical forces to generate the high energy phosphates ...
Colin D McCaig
Colin D McCaig
Packaging of DNA into viruses in some cases involves remarkably sophisticated electrical control mechanisms. One example is how the T4 bacteriophage uses an electrostatically driven motor to pump DNA into the viral capsid. ...
Colin D McCaig
Colin D McCaig
One of the most important and challenging biological events of recent times has been the pandemic caused by SARS-CoV-2. Since the underpinning argument behind this book is the ubiquity of electrical forces driving multiple disparate biologi...
Synaptic Physiology Depends on Electrical Forces and Liquid-Liquid Phase Separation [0.03%]
电学和液-液相分离决定突触生理功能
Colin D McCaig
Colin D McCaig
Pre- and post-synaptic events are regulated by liquid-liquid phase separation and this phenomenon requires multiple electrical forces. Both axonal transport and the organization of postsynaptic excitatory and inhibitory receptors are regula...
Colin D McCaig
Colin D McCaig
Several neurological diseases arise from abnormal protein aggregation within neurones and this is closely regulated by phase separation. One such is motor neurone disease and aberrant aggregation of superoxide dismutase. Again these events ...
Colin D McCaig
Colin D McCaig
It is now well-recognized that biological catalysis depends crucially on spatially regulated electrical forces for optimal efficiency. Several examples of the mechanisms underpinning this will be covered, as will the experimental evidence t...
Colin D McCaig
Colin D McCaig
Ribosomes use multiple electrical forces to regulate new protein construction, to ensure efficient protein cotranslation, chaperoning, and folding. When these electrical regulatory forces are disrupted as in point charge mutations, specific...
Colin D McCaig
Colin D McCaig
Nucleic acids are highly charged, and electrical forces are involved heavily in how our DNA is compacted and packaged into such a small space, how chromosomes are formed, and how DNA damage is repaired. In addition, electrical forces are cr...