Influence of ultraviolet C bystander effect on inflammatory response in A375 cell on subsequent exposure to ultraviolet C or hydrogen peroxide [0.03%]
UVC旁观者效应诱导的A375细胞炎症反应及其记忆效应
Dipanjan Guha,Sudipta Bhowmik,Rita Ghosh
Dipanjan Guha
Ultraviolet C (UVC) irradiation (λ: 200-280 nm) causes release of several secretory cytokines responsible for inflammation. Our objective was to investigate whether inflammatory response was also induced in bystander cells. For this purpos...
Leishmania donovani secretory serine protease alters macrophage inflammatory response via COX-2 mediated PGE-2 production [0.03%]
利什曼原虫分泌型丝氨酸蛋白酶通过COX-2介导的PGE2产生改变巨噬细胞炎性反应
Partha Das,Tripti De,Tapati Chakraborti
Partha Das
Leishmania parasites determine the outcome of the infection by inducing inflammatory response that suppresses macrophage's activation. Defense against Leishmania is dependent on Th1 inflammatory response by turning off macrophages' microbic...
TLR4-mediated activation of MyD88 signaling induces protective immune response and IL-10 down-regulation in Leishmania donovani infection [0.03%]
TLR4介导的MyD88信号活化诱导利什曼原虫感染小鼠保护性免疫反应并下调IL-10水平
Joydeep Paul,Kshudiram Naskar,Sayan Chowdhury et al.
Joydeep Paul et al.
In visceral leishmaniasis, a fragmentary IL-12 driven type 1 immune response along with the expansion of IL-10 producing T-cells correlates with parasite burden and pathogenesis. Successful immunotherapy involves both suppression of IL-10 p...
Challenges of ionizing radiation in tumor treatment and role of angiogenesis [0.03%]
肿瘤放射治疗中的挑战及血管生成的作用
Subir Kumar Das
Subir Kumar Das
Ionizing radiation is a non-specific, but most widely used therapeutic method for cancer treatment. However, a minor fraction of tumor cell population manages to survive after radiation. Radiation efficacy depends on adequate oxygen supply....
Signaling pathways in insulin- and IGF-I mediated oocyte maturation in lower vertebrates [0.03%]
下等脊椎动物中胰岛素和IGF-I介导的卵母细胞成熟的信号途径
Dilip Mukherjee,Suravi Majumder,Sujata Roy Moulick et al.
Dilip Mukherjee et al.
The endocrine control of oocyte maturation in fish and amphibians has proved to be a valuable model for investigating the rapid and non-genomic steroid actions at the cell surface. Considerable progress has made over the last decade in eluc...
Phospholipid remodeling and eicosanoid signaling in colon cancer cells [0.03%]
结肠癌细胞中的卵磷脂重构和二十烷酸信号转导
Siddhartha Das,Leobarda Robles Martinez,Suparna Ray
Siddhartha Das
Phospholipid remodeling and eicosanoid synthesis are central to lipid-based inflammatory reactions. Studies have revealed that membrane phospholipid remodeling by fatty acids through deacylation/reacylation reactions increases the risk of c...
Regulation of N-myristoyltransferase by the calpain and caspase systems [0.03%]
钙蛋白酶和半胱氨酸天冬氨酸蛋白酶系统对N-十四酰基转移酶的调控作用研究
Rajendra K Sharma,Sujeet Kumar,Sreejit Parameswaran et al.
Rajendra K Sharma et al.
N-myristoyltransferase (NMT) is an essential eukaryotic enzyme which catalyzes the transfer of the myristoyl group to the terminal glycine residue of a number of proteins including those involved in signal transduction and apoptotic pathway...
Lung retinoid metabolism and signaling in chronic obstructive pulmonary disease [0.03%]
慢性阻塞性肺疾病的肺维生素A代谢和信号转导
Salil K Das,Somdutta Sinha Roy,Shyamali Mukherjee et al.
Salil K Das et al.
There are a number of sites that are required for the production and/or action of all-trans retinoic acid (ATRA). In particular, interruption of different components of the chain of trafficking and metabolism has been associated with cancer...
Alpana Ray,Mohamed Alalem,Bimal K Ray
Alpana Ray
The primary function of insulin is viewed as a hormone that controls blood glucose level. However, there is growing evidence that aberrant insulin level and insulin-mediated signaling can lead to cancer development and progression. The insu...
Belma Turan,Erkan Tuncay
Belma Turan
Beta-adrenoceptors (β-AR), members of the G protein-coupled receptors play important roles in the regulation of heart function. A positive inotropic action of catecholamines is mediated through their interaction with β-AR, located on the ...