Expression and response surface optimization of the recovery and purification of recombinant D-galactose dehydrogenase from Pseudomonas fluorescens [0.03%]
荧光假单胞菌中D-半乳糖脱氢酶的表达及其纯化工艺优化
Shadi Rokhsartalab Azar,Raika Naiebi,Ameneh Homami et al.
Shadi Rokhsartalab Azar et al.
The enzyme D-galactose dehydrogenase (GalDH) has been used in diagnostic kits to screen blood serum of neonates for galactosemia. It is also a significant tool for the measurement of β-D-galactose, α-D-galactose and lactose as well. In th...
Purification, characterization and synthetic application of a thermally stable laccase from Hexagonia tenuis MTCC-1119 [0.03%]
霍克斯冈菌种MTCC-1119耐热型漆酶的纯化、表征及合成应用研究
Pankaj Kumar Chaurasia,Shashi Lata Bharati,Sudha Yadava et al.
Pankaj Kumar Chaurasia et al.
A thermally stable laccase was purified from the culture filtrate of Hexagonia tenuis MTCC-1119. The method involved concentration of the culture filtrate by ammonium sulphate precipitation and an anion-exchange chromatography on diethylami...
Structural analysis and molecular docking of potential ligands with chorismate synthase of Listeria monocytogenes: a novel antibacterial drug target [0.03%]
色氨酸合成酶的结构分析及分子对接： listeria monocytogenes 新型抗菌药靶点研究
Md Musharaf Hossain,Pradip Kumar Roy,A T M Jannatul Mosnaz et al.
Md Musharaf Hossain et al.
Listeriosis, in particular that caused by Listeria monocytogenes, is a major foodborne pathogen, and its control is becoming difficult because of widespread emergence of drug resistance strains. Chorismate synthase (CS), an essential enzyme...
Computational prediction of MHC class I epitopes for most common viral diseases in cattle (Bos taurus) [0.03%]
奶牛常见病毒疾病的MHC-I表位的计算预测(塔urus)
Tanmaya Kumar Sahu,A R Rao,Prabina Kumar Meher et al.
Tanmaya Kumar Sahu et al.
Viral diseases like foot-and-mouth disease (FMD), calf scour (CS), bovine viral diarrhea (BVD), infectious bovine rhinotracheitis (IBR) etc. affect the growth and milk production of cattle (Bos taurus) causing severe economic loss. Epitope-...
Serum neuron-specific enolase and S-100β levels as prognostic follow-up markers for oxygen administered carbon monoxide intoxication cases [0.03%]
一氧化碳中毒高压氧治疗后预后判定指标NSE及S-100β的临床意义分析
Ali Osman Yildirim,Murat Eroglu,Umit Kaldirim et al.
Ali Osman Yildirim et al.
Serum neuron-specific enolase (NSE) and S-100β levels are considered novel biochemical markers of neuronal cell injury. In this study, the initial and post-treatment levels of NSE and S-100β were compared in carbon monoxide (CO) poisoning...
Analyzing resistance pattern of non-small cell lung cancer to crizotinib using molecular dynamic approaches [0.03%]
基于分子动力学方法分析非小细胞肺癌对克里唑蒂尼耐药性模式
Anish Kumar,K Ramanathan
Anish Kumar
Crizotinib is the potential anticancer drug used for the treatment of non-small cell lung cancer (NSCLC) approved by FDA in 2011. The main target for the crizotinib is anaplastic lymphoma kinase (ALK). Evidences available indicate that doub...
Effect of different serine protease inhibitors in validating the 115 kDa Leishmania donovani secretory serine protease as chemotherapeutic target [0.03%]
不同丝氨酸蛋白酶抑制剂对115kDa杜氏利什曼原虫分泌型丝氨酸蛋白酶药理作用靶点的验证效果
Tapati Chakraborti,Partha Das,Rajdeep Choudhury et al.
Tapati Chakraborti et al.
Proteases have been considered as an important group of targets for development of antiprotozoal drugs due to their essential roles in host-parasite interactions, parasite immune evasion, life cycle transition and pathogenesis of parasitic ...
Beta catenin is degraded by both caspase-3 and proteasomal activity during resveratrol-induced apoptosis in HeLa cells in a GSK3β-independent manner [0.03%]
茋诱发的HeLa细胞凋亡过程中GSK3β非依赖性的通过caspase-3和泛素-蛋白酶体系统降解β-catenin
Mahan Ray,Neha Rai,Kuladip Jana et al.
Mahan Ray et al.
Increased activity of β-catenin, an important transcriptional activator for survival and proliferation-associated genes has been linked with many cancers. We examined whether β-catenin is a target of resveratrol and whether its degradatio...
Herbicide paraquat induces sex-specific variation of neuroinflammation and neurodegeneration in Drosophila melanogaster [0.03%]
除草剂百草枯诱导果蝇神经炎症和神经变性性别特异性差异的研究
Shauryabrota Dalui,Arindam Bhattacharyya
Shauryabrota Dalui
There are several reports on herbicide paraquat (PQ)-induced Parkinsonian-like pathology in different animal models, including Drosophila melanogaster. Also, the role of some inflammatory factors, such as nitric oxide is reported in PQ-indu...
Lys-413 of S-phase mRNA cycling sequence binding protein from Leishmania donovani (LdCSBP) is modified through monoubiquitination that is responsible for inhibition of its riboendonuclease activity [0.03%]
利什曼原虫周期性mRNA结合蛋白的单泛素化抑制其RNase活性并调控细胞周期相关基因表达
Kasturi Guha,Sneha Das,Partha Saha
Kasturi Guha
In addition to well-known process of proteasome-mediated degradation of polyubiquitinated proteins, monoubiquitination of proteins is also an important post-translational modification that regulates various non-degradative cellular processe...