Adolescents with childhood-onset GHD: how do we get them to peak bone mass? [0.03%]
儿童期起病的生长激素缺乏青少年：如何达到峰值骨密度？
Stephen Shalet
Stephen Shalet
The development of osteoporosis, with its attendant risk of fragility fracture, is in part related to the peak bone mass (PBM) achieved in early adulthood. Adolescence is a critical time for the acquisition of bone mass, with around 40% of ...
Laura K Bachrach
Laura K Bachrach
Bone densitometry is used to assess skeletal health in clinical and research settings, with the goal of achieving reproducible measurements of bone mass that help to identify individuals predisposed to fracture. The search is now on for bet...
Eckhard Schoenau
Eckhard Schoenau
It is now thought that the critical property of bone is strength rather than weight, and that control of bone strength is mainly exercised through the effect of the mechanical loads brought to bear on bone. Muscle contraction places the gre...
P L Hofman,F Regan,W S Cutfield
P L Hofman
Low birth weight is associated with both later adult diseases such as type 2 diabetes mellitus and a number of metabolic abnormalities, the foremost of which is insulin resistance. Indeed the link between an adverse perinatal environment, m...
Inflammatory markers in adults with Prader-Willi syndrome before and during 12 months growth hormone treatment [0.03%]
普纳德-威利综合征成人患者治疗前及长达一年生长激素治疗期间的炎症标志物水平变化
Charlotte Höybye
Charlotte Höybye
Background: In Prader-Willi syndrome (PWS) obesity and partial growth hormone (GH) deficiency are frequently observed. The risks of cardiovascular diseases and early death are increased. We examined inflammatory markers i...
Clinical Trial
Hormone research. 2006;66(1):27-32. DOI:10.1159/000093229 2006
Subclinical hypothyroidism in HIV-infected patients is not an autoimmune disease [0.03%]
HIV感染患者亚临床甲状腺功能减退不是自身免疫性疾病
S Beltran,F-X Lescure,I El Esper et al.
S Beltran et al.
Aims and methods: A study of 350 HIV+ patients in our region showed that 16% suffered from hypothyroidism. Twenty-two HIV+ hypothyroid patients (10 with subclinical hypothyroidism, 12 with low FT4 levels (LT4) (confirmed ...
Validation of a calibrated prediction model for response to growth hormone treatment in an independent cohort [0.03%]
在一个独立的队列中验证生长激素治疗反应的校准预测模型的有效性
Maria A J de Ridder,Theo Stijnen,Stenvert L S Drop et al.
Maria A J de Ridder et al.
Background: Prediction models, e.g. for prediction of response to growth hormone treatment, need validation in appropriate independent cohorts, comparing predicted and observed outcomes. In a previous validation of a mode...
Benefits of screening in von Hippel-Lindau disease--comparison of morbidity associated with initial tumours in affected parents and children [0.03%]
von Hippel Lindau病筛查的好处－与受累父母和子女初次肿瘤相关的发病率的比较
M Priesemann,K M Davies,L A Perry et al.
M Priesemann et al.
Von Hippel-Lindau (VHL) is a rare autosomal dominant syndrome characterised by the association of retinal and CNS haemangioblastomas, phaeochromocytoma and renal cell carcinoma. If a child of an affected parent has inherited a VHL mutation ...
Case Reports
Hormone research. 2006;66(1):1-5. DOI:10.1159/000093008 2006
T Nübel,D Ricquier
T Nübel
The term 'uncoupling protein' was originally used for the mitochondrial membrane protein UCP1, which is uniquely present in mitochondria of brown adipocytes, thermogenic cells that regulate body temperature in small rodents, hibernators and...
Maternal and cord blood ghrelin in the pregnancies of smoking mothers: possible markers of nutrient availability for the fetus [0.03%]
吸烟母亲妊娠期母体和脐带血中胃泌素的水平：胎儿营养可用性的潜在标志物
Natacha Bouhours-Nouet,Florence Boux de Casson,Stéphanie Rouleau et al.
Natacha Bouhours-Nouet et al.
Aims: To investigate the role of ghrelin in maternal and fetal metabolism, we determined its value in maternal smoking, a specific cause of reduced placenta function and fetal growth. ...