Etiology and biomechanics of first metatarsophalangeal joint sprains (turf toe) in athletes [0.03%]
运动员第一跖趾关节扭伤（草地脚大拇指）的病因及生物力学分析
Rebecca E Frimenko,W Lievers,Michael J Coughlin et al.
Rebecca E Frimenko et al.
Sprains of the first metatarsophalangeal (MTP) joint, referred to colloquially as "turf toe," are a debilitating sports injury because the hallux is pivotal to an athletes' ability to accelerate and cut. Severe sprains may require weeks to ...
Nanoscale drug delivery systems for enhanced drug penetration into solid tumors: current progress and opportunities [0.03%]
用于增强药物向实体瘤渗透的纳米载药系统：进展与机遇
Carolyn L Waite,Charles M Roth
Carolyn L Waite
Poor penetration of anticancer drags into solid tumors significantly limits their efficacy. This phenomenon has long been observed for small-molecule chemotherapeutics, and it can be even more pronounced for nanoscale therapies. Nanoparticl...
Diffusion tensor imaging in the human spinal cord: development, limitations, and clinical applications [0.03%]
人脊髓弥散张量成像的发展、局限性及临床应用
R Bosma,Patrick W Stroman
R Bosma
Diffusion tensor imaging (DTI) is currently the only non-invasive in vivo assessment of white matter tract integrity. Capitalizing on the diffusion properties of water within an axon, DTI enables the visualization of tissue structure at a m...
Role of substrates in diabetes therapy: stem cell differentiation and islet transplantation [0.03%]
糖尿病治疗中底物的作用：干细胞分化和胰岛移植
Joseph E Candiello,Maria Jaramillo,Saik-Kia Goh et al.
Joseph E Candiello et al.
Type 1 diabetes affects more than a million people in the United States and many more across the world. While pharmaceutical interventions and insulin supplementation are the most commonplace treatment of diabetes, these are not essentially...
Advanced stoichiometric analysis of metabolic networks of mammalian systems [0.03%]
哺乳动物系统代谢网络的先进计量分析
Mehmet A Orman,Francois Berthiaume,Ioannis P Androulakis et al.
Mehmet A Orman et al.
Metabolic engineering tools have been widely applied to living organisms to gain a comprehensive understanding about cellular networks and to improve cellular properties. Metabolic flux analysis (MFA), flux balance analysis (FBA), and metab...
Carolyne Albert,Hanspeter Frei,Clive Duncan et al.
Carolyne Albert et al.
Failure of the femoral component of total hip arthroplasty is often accompanied by bone loss that can pose a significant challenge to the orthopaedic surgeon. Femoral impaction allografting has attractive potential for restoring bone stock ...
N V Krishnamurthy,Barjor Gimi
N V Krishnamurthy
Cell transplantation provides a therapeutic alternative to whole organ transplantation in the management of diseases arising from the absence or failure of specialized cells. Though allogenic transplantation is favorable in terms of graft a...
Mathematical and computational models of oxidative and nitrosative stress [0.03%]
氧化应激和硝化应激的数学模型与计算模型
Mahendra Kavdia
Mahendra Kavdia
The importance of nitric oxide (NO), superoxide (O2-), and peroxynitrite (ONOO-), interactions in physiologic functions and pathophysiological conditions such as cardiovascular disease, hypertension, and diabetes have been established exten...
Modeling Ca2+ signaling in the microcirculation: intercellular communication and vasoreactivity [0.03%]
微循环中的钙离子信号传导：细胞间通讯和血管反应性
Adam Kapela,Sridevi Nagaraja,Jaimit Parikh et al.
Adam Kapela et al.
A network of intracellular signaling pathways and complex intercellular interactions regulate calcium mobilization in vascular cells, arteriolar tone, and blood flow. Different endothelium-derived vasoreactive factors have been identified a...
Donald G Buerk,Kenneth A Barbee,Dov Jaron
Donald G Buerk
Several apparent paradoxes are evident when one compares mathematical predictions from models of nitric oxide (NO) diffusion and convection in vasculature structures with experimental measurements of NO (or related metabolites) in animal an...