Mixtures of logistic normal multinomial regression models for microbiome data [0.03%]
微生物数据的逻辑正态多项式回归混合模型
Wenshu Dai,Yuan Fang,Sanjeena Subedi
Wenshu Dai
In the realm of bioinformatics, we frequently encounter discrete data, particularly microbiome taxa count data obtained through 16S rRNA sequencing. These microbiome datasets are commonly characterized by their high dimensionality and the a...
Johnny Hong,Sara Stoudt,Perry de Valpine
Johnny Hong
Hierarchical statistical models are important in applied sciences because they capture complex relationships in data, especially when variables are related by space, time, sampling unit, or other shared features. Existing methods for maximu...
Modeling the time to dropout under phase-wise variable stress fixed cohort setup [0.03%]
分阶段变量应力固定队列设定下辍学时间的建模
Aniket Biswas,Subrata Chakraborty,Anupama Nandi
Aniket Biswas
The event of a student dropping out from an academic program depends on several factors namely course content, change in interest, financial problems among many others. These factors vary interdependently with different phases of the academ...
A novel Phase II single-arm hybrid design to minimize trial duration and enhance subsequent Phase III trial success rate [0.03%]
一种新型的二期单臂混合设计以最小化试验时长并提高后续三期试验成功率
Jun Lu,Yuzi Zhang,Ying Cui et al.
Jun Lu et al.
Many Phase III trials fail for lack of significant efficacy for the testing agents although their success has been demonstrated in preceding Phase II trials. One of the major reasons for this discordance is the use of different endpoints in...
Fast algorithms of computing admissible intervals for discrete distributions with single parameter [0.03%]
单参数离散分布可接受区间快速计算算法
Weizhen Wang,Chongxiu Yu,Zhongzhan Zhang
Weizhen Wang
It is of great interest to compute optimal exact confidence intervals for the success probability (p) in a binomial distribution, the number of subjects with a certain attribute (M) or the total number of subjects (N) in a hypergeometric di...
A two-sample nonparametric test for one-sided location-scale alternative [0.03%]
单侧位置尺度替代的两样本非参数检验方法研究
Hidetoshi Murakami,Markus Neuhäuser
Hidetoshi Murakami
An increase in location is often accompanied by an increase in variability. Moreover, in randomized studies, the presence of heteroscedasticity can indicate a treatment effect. In these cases a location-scale test is appropriate. A common a...
Raja Fawad Zafar,Michael B C Khoo,Huay Woon You et al.
Raja Fawad Zafar et al.
A partitioned weighted moving average (PWMA) chart is developed by partitioning the samples (or observations) into two groups, calculating the groups' weighted average and adding them. This partitioning gives more control over weight distri...
Performance of tests based on the area under the ROC curve for multireader diagnostic data [0.03%]
基于ROC曲线下面积的多读者诊断数据测试性能
Yi-Ting Hwang,Ya-Ru Hsu,Nan-Cheng Su
Yi-Ting Hwang
One of the main objectives of disease prevention is to lower the healthcare costs and improve the quality of life. To achieve this, reliable diagnostic tools are needed. The diagnostic performance of a tool can be measured by the ROC curve ...
Estimating changepoints in extremal dependence, applied to aviation stock prices during COVID-19 pandemic [0.03%]
估计极端依赖性的变化点，在COVID-19疫情期间应用于航空股票价格的变化分析
Arnab Hazra,Shiladitya Bose
Arnab Hazra
The dependence in the tails of the joint distribution of two random variables is generally assessed using χ-measure, the limiting conditional probability of one variable being extremely high given the other variable is also extremely high....
Sample size calculation for the sequential parallel comparison design with binary endpoint using exact methods [0.03%]
使用精确算法的序列平行比较设计二分类结局样本量估算
Guogen Shan,Yahui Zhang
Guogen Shan
High placebo responses in clinical trial could reduce the treatment effect leading to the failure of a promising drug. Several strategies have been developed to minimize high placebo responses, including the sequential parallel comparison d...