[shRNA-mediated downregulation of TERT inhibits melanoma in vitro and in vivo] [0.03%]
利用shRNA下调TERT基因抑制黑色素瘤的生长与发展
Y T Yang,J Zhao,T T Li et al.
Y T Yang et al.
Objective: To investigate the anti-tumor effect of knockdown of telomerase reverse transcriptase (TERT) in melanoma and its potential clinical value. Methods: Employed TERT knockdown strategy and evaluated the expression of target gene by W...
[Exploration on the application of perineal lateral arc-shaped incision in the resection of complex tumors on the lateral side of the pelvic floor] [0.03%]
会阴外侧弧形切口在骨盆下侧复杂肿瘤切除中应用的探讨
L L Guo,G C Wang,W C Ai et al.
L L Guo et al.
Objective: To investigate the surgical approach for the resection of complex tumors located on the lateral side of the pelvic floor. Methods: A retrospective analysis was conducted on 24 patients with complex tumors on the lateral side of t...
[Risk stratification assessment of brain metastasis in newly diagnosed non-stage IV breast cancer patients with HER-2-low expression following systemic therapy] [0.03%]
[HER-2低表达新诊断非IV期乳腺癌系统治疗后脑转移风险分层评估]
X Wang,Q Y Liu,H L Du et al.
X Wang et al.
Objective: To explore the independent risk factors of brain metastasis after systematic treatment in newly diagnosed non-stage Ⅳ breast cancer patients with HER-2-low expression, and to determine the recurrence risk stratification of brain...
[Clinicopathological analysis of SMARCA4-deficient tumors of digestive system origin] [0.03%]
消化系统来源SMARCA4缺陷型肿瘤的临床病理分析
F X Wang,T Ning,M Bai et al.
F X Wang et al.
Objective: To analyze the clinicopathological characteristics, treatment, and prognosis of SMARCA4-deficient tumors of digestive system origin, and to deepen the understanding of this tumor subtype. Methods: A retrospective analysis was con...
[cfDNA sequencing reveals response heterogeneity to first-line camrelizumab plus chemotherapy in esophageal squamous cell carcinoma] [0.03%]
[通过cfDNA测序揭示一线卡瑞利珠单抗联合化疗治疗食管鳞癌的异质性响应]
X L Zhang,H Wang,W X Fan et al.
X L Zhang et al.
Objective: To analyze the heterogeneity of response to first-line camrelizumab combined with chemotherapy in patients with esophageal squamous cell carcinoma (ESCC) by pretreatment circulating cell-free DNA (cfDNA) sequencing. Methods: A to...
[Efficacy and safety of combination immunotherapy for locally advanced esophageal carcinoma] [0.03%]
[局部晚期食管癌联合免疫治疗疗效和安全性分析]
S Ma,Y Tan,H F Wang et al.
S Ma et al.
Objective: To investigate the efficacy and safety of combination immunotherapy in patients with locally advanced esophageal cancer. Methods: Clinical data of 212 patients with pathologically confirmed locally advanced esophageal cancer who ...
[MiR-527 targeting Bcl-2 inhibits migration and promotes apoptosis in bladder urothelial cell carcinoma] [0.03%]
[ MiR-527通过靶向Bcl-2抑制移行细胞癌的迁移并促进其凋亡 ]
L Ma,Y Y Zhang,L Wang et al.
L Ma et al.
Objective: To investigate the expression of miR-527 in bladder urothelial cell carcinoma tissues (UCC) and cell lines, and to explore the mechanism by which miR-527 inhibits bladder cancer cell migration and promotes apoptosis through targe...
[miR-1910-3p affects proliferation, invasion and in vivo tumor growth of lung adenocarcinoma by inducing epithelial-mesenchymal transition] [0.03%]
[通过诱导上皮间质转化促进肺腺癌增殖、侵袭及体内成瘤作用的miR-1910-3p研究]
M X Fang,X X Yu,J F Huang et al.
M X Fang et al.
Objective: To investigate the effects of miR-1910-3p on proliferation, invasion, epithelial-mesenchymal transition (EMT) and in vivo tumor growth of lung adenocarcinoma (LUAD) cells. Methods: Bioinformatics analysis was performed using The ...
[Advances in neoadjuvant therapy for EGFR-mutant non-small cell lung cancer] [0.03%]
EGFR突变型非小细胞肺癌新辅助治疗进展
Y Q Wu,R B Zhong
Y Q Wu
Epidermal growth factor receptor (EGFR) mutation is the most common driver mutation in non-small cell lung cancer (NSCLC) among Asian populations. For patients with resectable EGFR-mutant NSCLC, the high risk of postoperative recurrence rem...
[Consensus of Chinese experts on the multidisciplinary management of adverse reactions to antibody-drug conjugates in the treatment of lung cancer (2025 edition)] [0.03%]
中国抗体药物偶联物治疗肺癌不良反应多学科管理专家共识(2025版)
Precision Treatment Branch of Thoracic Oncology, Chinese Geriatric Health Association
Precision Treatment Branch of Thoracic Oncology
Antibody-drug conjugates (ADCs) are covalently conjugated molecules composed of a monoclonal antibody, a payload, and a linker. They represent an innovative therapeutic approach that combines the precise targeting capability of target thera...