[Change of Tumor Cell Multiple Drug Resistance Inhibitory Activity of Oligomycins in Complexes with Lithium and Zinc] [0.03%]
寡霉素与锂、锌复合物抗肿瘤细胞多重耐药性变化的研究
M V Bibikova,A N Danilenko,A V Katlinsky et al.
M V Bibikova et al.
Oligomycins and their complexes with lithium and zinc were shown to be less active vs. cyclosporin A in inhibition of transport proteins responsible for multiple drug resistance of lymphoid leukosis P388VR cells, while certain oligomycin co...
[Antimicrobial Activity of Substances Produced by Trichoderma citrinoviride Strain VKPM F-1228: Optimization of Cultivation and Assessment of Spectrum of Individual Peptaibols] [0.03%]
由Trichoderma citrinoviride菌株VKPM F-1228产生的抗菌物质：培养优化及个别肽尾素抑菌谱的测定
V S Sadykova,A V Kurakov,V A Korshun et al.
V S Sadykova et al.
The Trichoderma citrinoviride VKPM F-1228 strain produces a complex of peptide-based antibiotics with antibacterial and antimycotic action. Synthesis of peptaibols is closely related to the conidiogenesis in the culture. The optimal procedu...
[Methods and Means for Defense from Collateral Action of Vaccine Virus after Vaccination Against Spallpox] [0.03%]
【天花疫苗接种后的副痘病毒偶合感染防御方法及手段研究】
N K Chernikova,T A Bondareva,S V Borisevich et al.
N K Chernikova et al.
In connection with actuality of smallpox vaccination at present its methods and means are discussed to increase the safety of the first immunization with live vaccines.
[Substantiation of Expressive Markers Use to Personalize Lung Cancer Chemotherapy] [0.03%]
[表达标记物用于肺癌化疗个体化的证据]
M M Tsyganov,E O Rodionov,S V Miller et al.
M M Tsyganov et al.
Surgery results of II-III stage lung cancer remain unsatisfactory and the chemotherapy does not improve the survival. The main obstacle is the use of the standard clinical parameters for the treatment strategy and not sufficiently effective...
[Biological Functions of Succinate (a Review of Foreign Experimental Studies)] [0.03%]
[琥珀酸的生物学功能及其研究进展]
V V Valeev,A L Kovalenko,E V Talikova et al.
V V Valeev et al.
The published data on the modern concept of the biological role of succinate, an intermediate of the citric acid cycle are analysed in the review. Special interest to succinate is determined by investigations on the mitochondrial functions ...
[Prospects of Pharmacogenetic Testing for Design of Algorithms for Personalized Treatment of Tuberculosis of Respiratory Organs in the Astrakhan Region] [0.03%]
[阿斯特拉罕地区呼吸系统结核病个性化治疗算法设计的药物基因组检测前景]
B I Kantemirova,Kh M Galimzyanov,N A Stepanova et al.
B I Kantemirova et al.
In spite of the availability of many antituberculosis drugs all over the world the morbidity of tuberculosis does not lower. Often the tuberculosis therapy schemes are adapted to every particular patient which is mainly due to the therapy u...
[Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated at Hospitals of St. Petersburg and Moscow] [0.03%]
俄罗斯列宁格勒和莫斯科几家医院分离的表皮葡萄球菌等凝固酶阴性葡萄球菌的耐药谱分析
V V Gostev,O S Kalinogorskaya,A N Kruglov et al.
V V Gostev et al.
Antibiotic susceptibility of 119 coagulase-negative staphylococci isolated at hospitals of St. Petersburg and Moscow was investigated and estimated at the local laboratories as oxacillin resistant. The following species were identified: Sta...
[Discovery of Genetic Markers of Resistance to β-Lactams in Gramnegative Microorganisms by PCR Diagnosis] [0.03%]
PCR诊断发现革兰氏阴性微生物β-内酰胺类抗生素耐药基因标志物
E S Lisitsina,T V Chernenkaya,E N Ilyina et al.
E S Lisitsina et al.
Fifteen specimens of the hemoculture and 89 specimens of the broncho-alveolar lavage were used in the study. Monocultures of gramnegative bacteria resistant to cefotaxime, cefepime, imipenem and meropenem were isolated from the specimens. T...
[PK/PD Modeling as a Tool for Predicting Bacterial Resistance to Antibiotics: Alternative Analyses of Experimental Data] [0.03%]
基于实验数据的细菌抗生素抗性预测的pkpd模型研究及其新方法学分析
M V Golikova,E N Strukova,Y A Portnoy et al.
M V Golikova et al.
Postexposure number of mutants (NM) is a conventional endpoint in bacterial resistance studies using in vitro dynamic models that simulate antibiotic pharmacokinetics. To compare NM with a recently introduced integral parameter AUBC(M), the...
[Design of Novel Carboxamides of Eremomycin and Vancomycin with 4- or 3-Amino Methyl Phenyl Boric Acid and Their Investigation] [0.03%]
[具4-或3-氨基甲基苯硼酸厄他美星和万古霉素衍生物的设计与研究]
E N Bychkova,A M Korolev,E N Olsufyeva et al.
E N Bychkova et al.
Amidation of the end carboxyl group of eremomycin and vancomycin by pinacolinic 4- or 3-amino methyl phenyl boron acids esters in the presence of the condensing reagent PyBOP resulted in formation of novel carboxamides of the antibiotics (I...