Multi-Scale Adaptive Temporal Network for Parkinson's Motor Symptom Fluctuation Detection Using Coarsened 2D Skeleton Pose Data [0.03%]
基于粗略二维骨骼姿态数据的帕金森病运动症状波动检测的多尺度自适应时序网络
Balamurugan Velumani,Sivasankari Krishnakumar
Balamurugan Velumani
Background: Parkinson's Disease (PD) is a neurological condition characterized by motor symptoms that fluctuate throughout the day depending on medication. Continuous and objective monitoring is essential, but conventiona...
Ashkan Asgari Gashtrodkhani,Samaneh Ghorbani Shirkouhi,Seyed Sepehr Khatami et al.
Ashkan Asgari Gashtrodkhani et al.
Alzheimer's disease (AD) is a progressive neurodegenerative disease that leads to a decline in cognitive function, including memory. The exact causes of AD are not fully understood, and to date no treatments are available that can stop the ...
Dual-Modified Mannose/RVG29 Peptide-Functionalized Lipid Nanoparticles Loaded With circHIPK2 siRNA Ameliorate Hypoxic-Ischemic Brain Damage in Neonatal Mice by Suppressing Astrocyte Activation [0.03%]
双修饰的甘露糖/ RVG29肽功能化载circHIPK2 siRNA的脂质纳米颗粒通过抑制星形胶质细胞活化改善新生小鼠缺氧缺血性脑损伤
Yinxia Dang,Fuhui Shen,Shengxia Wang et al.
Yinxia Dang et al.
Background: To address the unmet need for targeted therapeutic strategies for neonatal hypoxic-ischemic encephalopathy (HIE), we developed a brain-targeting lipid nanoparticle delivery system capable of silencing circular...
Cheng Yuan,Wen-Xuan Cao,Ming-Rui Liu et al.
Cheng Yuan et al.
The onset and progression of central nervous system (CNS) disorders are frequently associated with aberrant neuronal death. In addition to the classical forms of cell death such as apoptosis and necrosis, neurons can also undergo alternativ...
Quercetin Modulates Sleep Architecture and Homeostatic Recovery by Inhibiting Neuronal Hyperactivity and Microglial Activation in Mice [0.03%]
檞皮素通过抑制小鼠神经元过度活跃和小胶质细胞活化来调节睡眠结构和稳态恢复
Ruifang Hua,Beibei Wu,Peiyang Fu et al.
Ruifang Hua et al.
Background: Quercetin is a naturally occurring flavonoid widely distributed in plants that exhibits various biological activities, including anti-inflammatory, antioxidant, and neuroprotective effects. It exhibits a poten...
Ying Liu,Jing Ning,Jiarui Ma et al.
Ying Liu et al.
Background: Inhibitory control is an important component of cognitive processing that is influenced by multimodal information processing. Recent research has mainly focused on the influence of visual information on inhibi...
Impaired Proteasome as a Catalyst for cGAS-STING Activation in Alzheimer's Disease [0.03%]
阿尔茨海默病中蛋白酶体功能受损促进cGAS-STING活化
Abena Dwamena,Hongmin Wang
Abena Dwamena
Spinal Dorsal Horn Neuronal Alterations Following CFA-Induced Inflammatory Pain in Mice [0.03%]
CFA诱导的小鼠炎症痛性状下的脊髓背角神经元变化
Hao Zheng,Xiaoyue Sun,Qingquan Yu et al.
Hao Zheng et al.
Background: The spinal dorsal horn (SDH) plays a crucial role in nociceptive processing. However, the temporal dynamics of neuronal excitability across different laminae during inflammatory pain remain incompletely unders...
From Silence to Awakening: The Role of Amplitude of Low-Frequency Fluctuations in Predicting Recovery After Spinal Cord Stimulation [0.03%]
从沉默到觉醒：低频波动幅度在脊髓刺激后预测恢复中的作用
Xuewei Qin,Xuanling Chen,Lan Yao et al.
Xuewei Qin et al.
Background: Disorders of consciousness (DoCs) following traumatic brain injury (TBI), or cerebrovascular disease (CVD) are difficult to prognose, as reliable biomarkers are lacking. Resting-state functional magnetic reson...
Mechanisms of Astrocyte Action in the Blood Brain Barrier: From Structural Support to Dynamic Regulation [0.03%]
astrocyte调控血脑屏障的作用机制：从结构支持到动态调节
Di Feng,Lili Wang,Aoyu Hu et al.
Di Feng et al.
The blood-brain barrier (BBB) consists of endothelial cells enmeshed by brain microvessels, surrounding basement membrane, pericytes and astrocyte pedicles. It serves as a natural barrier between the blood and brain tissue and both its stru...