Tauroursodeoxycholic Acid Exerts Neuroprotective Effects in Epilepsy via Suppression of Ferroptosis [0.03%]
鹅去氧胆酸通过抑制铁死亡对癫痫发挥神经保护作用
Lihui Wang,Yijiao Long,Fei Wang et al.
Lihui Wang et al.
Background: Epilepsy is a complex neurological disorder marked by recurrent, unprovoked seizures. Ferroptosis is characterized by the accumulation of oxidative stress and is associated with the occurrence and development ...
The Icelandic Mutation in the Murine APP Gene, mAPPA673T, on Amyloid-β Plaque Burden in the 5×FAD Alzheimer Model [0.03%]
冰岛突变体mAPPA673T对五倍人类早老素1转基因小鼠脑内淀粉样蛋白斑沉积的影响
Anne Anschuetz,Renny Listyono,Thomas Vorley et al.
Anne Anschuetz et al.
Background: The protective Icelandic mutation in the amyloid precursor protein (APP) gene, APPA673T, identified in Icelandic and other Nordic populations is associated with a significantly lower risk of developing Alzheim...
Electroacupuncture Modulation of Chondroitin Sulfate Glycosaminoglycan Promotes the Repair of Damaged Spinal Cord in Rats [0.03%]
电针调节硫酸软骨素糖胺聚糖促进大鼠损伤脊髓的修复
Bowen Chen,Rong Hu,Xingying Wu et al.
Bowen Chen et al.
Background: The perineuronal net (PNN) is an important extracellular environment around parvalbumin interneuron (PV IN) in the spinal cord. Chondroitin sulfate proteoglycan (CSPG) serves as a key factor mediating PNN effe...
Roflupram Reduces 6-OHDA-Induced Cellular Damage in SH-SY5Y Cells by Inhibiting PDE4 [0.03%]
罗氟普拉姆通过抑制PDE4减少6-HD诱导的SH-SY5Y细胞损伤
Jiahong Zhong,Xihui Yu,Junling Xue et al.
Jiahong Zhong et al.
Background: The main symptoms of Parkinson's disease (PD) include olfactory impairment and tremor. Current treatment methods for PD generally have limitations such as short duration and severe side effects. The novel phos...
Lutein Attenuates Parkinson's Disease Progression by Regulating Mitochondrial Function via the TRIM31/Drp1 Signaling Pathway [0.03%]
通过TRIM31/Drp1信号通路调节线粒体功能，叶黄素减轻帕金森病的进展
Jiabin Duan,Wenbin Duan,Xiaomin Pu et al.
Jiabin Duan et al.
Background: Mitochondrial dysfunction is closely associated with the pathogenesis of Parkinson's disease (PD). Lutein has been shown to exert protective effects in neurological disorders. This study aimed to investigate t...
Maurizio Gorgoni,Valentina Alfonsi,Luigi De Gennaro
Maurizio Gorgoni
Electrophysiological studies have played a crucial role for the present conceptualization of Insomnia Disorder (ID) as a 24-h disorder characterized by hyperarousal expressed during wakefulness and sleep. In this Opinion piece, we highlight...
Adipose-Derived Stem Cells Transfected to Express Brain-Derived Neurotrophic Factor Reduce Hippocampal Amyloid Plaque Load and Improve Dendritic Morphology in the APP/PS1dE9 Mouse Model of Alzheimer's Disease [0.03%]
转基因表达脑源性神经营养因子的脂肪来源干细胞减少APP / PS1dE9型阿尔茨海默病小鼠海马淀粉样蛋白斑块负荷并改善树突形态学
Yuzhen Luo,Yiheng Liu,Hui Long et al.
Yuzhen Luo et al.
Background: Recent studies have indicated that stem cells could provide therapeutic benefits in several neurological conditions, including Alzheimer's disease (AD). Adipose-derived stem cells (ADSCs) offer many advantages...
Association of Functional and White Matter Structural Brain Network in Older Cerebral Small Vessel Disease With Cognitive Impairment [0.03%]
功能和白质结构脑网络在老年人小血管性脑病中的关联与认知障碍
Yumeng Gu,Jing Zhao,Wenjun Feng et al.
Yumeng Gu et al.
Background: To investigate topological brain network properties, intra- and inter-network network patterns, rich-club organization, structural-functional coupling, and their associations with cognitive impairment in elder...
Effect of Maternal Hyperglycemia on Cortical Neuronal Migration: Hypofunction of Reelin Signaling [0.03%]
母体高血糖对皮层神经元迁移的影响：Reelin信号传导功能降低
Rocío Valle-Bautista,Itzamara Soto-Villanueva,Dafne A Díaz-Piña et al.
Rocío Valle-Bautista et al.
Background: Maternal diabetes increases the risk of neurodevelopmental alterations in the offspring, yet the molecular links to early corticogenesis remain unclear. During corticogenesis, radial migration is a coordinated...
Effect of Physical Activity on Cognitive Function of Patients With Alzheimer's Disease: A Meta-analysis [0.03%]
运动对阿尔茨海默病患者认知功能影响的荟萃分析研究
Shengyu Dai,Shunling Yuan,Xinbi Zhang et al.
Shengyu Dai et al.
Background: Physical activity (PA) is a widely accepted non-pharmacological therapy for patients with Alzheimer's disease (AD). Existing studies have demonstrated that PA can improve cognitive function in AD patients. How...