Exploring the Microbiome-Kynurenine Axis in Mild Cognitive Impairment: From Gut to Brain [0.03%]
从肠道到大脑：探究轻度认知障碍中的微生物组-犬尿氨酸轴
Jiaxing Zhu,Haihua Xie,Yingke Ouyang et al.
Jiaxing Zhu et al.
Mild cognitive impairment (MCI) represents a critical prodromal stage of Alzheimer's disease. This review synthesizes current evidence to present a coherent pathological cascade driving MCI progression: gut microbiota dysbiosis (e.g., enric...
Assessing Cumulative Mental Fatigue via EEG-Based Machine Learning in a Multiday High-Intensity Contest [0.03%]
基于EEG的机器学习评估多日高强度竞赛中的累积精神疲劳
Xiaodong Yang,Jie Zhou,Zhan Chen et al.
Xiaodong Yang et al.
Background: Cumulative mental fatigue poses a significant threat to safety, productivity, and health in the workplace. In this study, we aimed to establish a robust machine learning framework using optimized resting-state...
Functional Diversity of Mouse dLGN Neurons and Modulation of Their Encoding Properties by Superior Colliculus [0.03%]
小鼠视板神经元的功能多样性及其编码特性受到上丘的调节
Xiaoying Ma,Chengyong Jiang,Wenbin Xie et al.
Xiaoying Ma et al.
Background: The dorsal lateral geniculate nucleus (dLGN) exhibits remarkable functional diversity, yet a systematic classification of its neuronal properties and the subcortical mechanisms that modulate these representati...
Antiseizure Medications Impact Mitochondrial Ion Channels via Novel Bioenergetic and Neural Mechanisms [0.03%]
抗惊厥药物通过新的生物能量和神经机制影响线粒体离子通道
Carmen Rubio,Norma Serrano-Garcia,Ricardo Pérez-Rubio et al.
Carmen Rubio et al.
Antiseizure medications (ASMs) have traditionally been characterized by their modulation of neuronal ion channels and synaptic processes; however, accumulating evidence indicates that numerous ASMs also directly modulate mitochondrial funct...
Small Extracellular Vesicles Derived From Mesenchymal Stem Cells Exert Neuroprotective Effect Against a Model of Dopamine Dysfunction by Inhibiting Caspase-8/Caspase-3-Mediated Apoptosis [0.03%]
外泌体来源的间充质干细胞通过抑制Caspase-8/Caspase-3介导的凋亡对抗多巴胺功能障碍模型发挥神经保护作用
Songzhe He,Qi Qu,Ling Hu et al.
Songzhe He et al.
Background: The precise pathological mechanisms driving Parkinson's disease (PD) progression remain incompletely understood, and there are currently no therapies that can modify the course of the disease. While mesenchyma...
Neural Correlates of Diagnostic-Relevant Emotional Processing in Schizophrenia and Major Depressive Disorder: Insights from a Replication of fMRI and Self-Report Scales [0.03%]
精神分裂症和抑郁症的诊断相关情绪加工的大脑机制：来自fMRI及自评量表的一项重复性研究
Elijah Agoalikum,Hongzhou Wu,Benjamin Klugah-Brown et al.
Elijah Agoalikum et al.
Background: Accurate differentiation between major depressive disorder (MDD) and schizophrenia (SZ) remains a clinical challenge due to overlapping symptoms and limitations of traditional diagnostic methods. Integrating n...
Serpinb2 is Upregulated in Dorsal Root Ganglia and Associated With Neuroinflammatory Changes in a Mouse Model of Neuropathic Pain [0.03%]
神经病理性疼痛小鼠模型中SERPINB2在背根神经节的表达上调并与神经炎症改变相关
Doudou Zhao,Ziye Jia,Ali Zou et al.
Doudou Zhao et al.
Background: Neuropathic pain (NP) is a refractory chronic pain condition that severely impairs quality of life, while currently available treatments often provide insufficient relief. Emerging evidence indicates that neur...
Advantages and Limitations of a Systemic and Ecological Assessment of Executive Functions in Children and Adolescents [0.03%]
儿童和青少年执行功能系统评估及生态评估的优势与局限性
Mélissa Weisse,Virginie Dardier,Solenne Scotto di Vettimo et al.
Mélissa Weisse et al.
Executive functions (EFs) are high-level functions of human cognition and have been studied since the early 20th century. The evolution of theoretical models of EFs highlights the importance of taking into account all systemic influences, w...
High-Frequency Repetitive Transcranial Magnetic Stimulation Improves Oxidative Stress, Iron Metabolism, and Synaptic Plasticity in the Visual Cortex of Amblyopic Rats: Association With the NRF2/GPX4 Pathway [0.03%]
高强度重复经颅磁刺激通过NRF2/GPX4通路改善弱视大鼠初级视觉皮质氧化应激、铁代谢及突触可塑性
Qin Li,Yinyin You,Qing Lu et al.
Qin Li et al.
Background: Amblyopia is a neurodevelopmental disorder with limited treatment efficacy after the developmental critical period. Repetitive transcranial magnetic stimulation (rTMS) improves visual perception in patients wi...
Glymphatic-Related Alterations in Major Depressive Disorder and Treatment-Resistant Depression: Imaging Proxies, Mechanistic Links, and Therapeutic Opportunities [0.03%]
抑郁症和难治性抑郁障碍中胶淋巴系统改变：影像标志物、机制关联及治疗机会
Tommaso Barlattani,Chiara D&#x;Amelio,Arianna Baschieri et al.
Tommaso Barlattani et al.
Major depressive disorder is increasingly conceptualized as a condition involving brain network dysfunction, neuroimmune imbalance, sleep-circadian disruption, hypothalamic-pituitary-adrenal (HPA)-axis dysregulation, monoaminergic arousal i...