Targeting Lipid Metabolism in Alzheimer's Disease: Emerging Insights and Future Directions [0.03%]
阿尔茨海默病脂质代谢紊乱的研究进展与未来方向
Jeyakumar Balakrishnan,Suganya Kannan,Kathiresan Shanmugam et al.
Jeyakumar Balakrishnan et al.
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease that is conventionally characterized by amyloid-β and tau pathology. There is growing evidence, however, that lipid metabolic disturbances are part of the biology of th...
Functional Connectivity Alterations in the Cholinergic Neural Circuits of Patients With Alzheimer's Disease: A Donepezil Intervention Study Using Resting-State Functional Magnetic Resonance Imaging [0.03%]
多奈哌齐干预阿尔茨海默病患者胆碱能神经环路功能连接改变的静息态功能磁共振成像研究
Yufei Guo,Zhenzhong Zhang,Bo Chen et al.
Yufei Guo et al.
Background: Although donepezil alleviates Alzheimer's disease (AD) symptoms by raising acetylcholine levels, its impact on cholinergic pathways remains unclear. In this longitudinal, resting-state functional magnetic reso...
Atractylodin Suppresses Fibrotic Scar Formation and Enhances Functional Recovery Following Spinal Cord Injury [0.03%]
羌独活内酯抑制脊髓损伤后纤维化瘢痕的形成并促进功能恢复
Zhenwei Li,Chao Fang,Chengcheng Feng et al.
Zhenwei Li et al.
Background: Fibrous scar formation significantly inhibits axonal regeneration and functional recovery following spinal cord injury (SCI). Atractylodin (ATD), an active constituent of traditional Chinese medicine, exhibits...
Regional Associations Between Ocular Vascular Parameters and Enlarged Perivascular Spaces in the Basal Ganglia and Centrum Semiovale [0.03%]
视网膜血管参数与基底节和半卵圆中心区域扩大血管周围空间的联系
Nuo Ma,Juan Tao,Qiong Dong et al.
Nuo Ma et al.
Background: Enlarged perivascular spaces (EPVS) represent a hallmark imaging feature of cerebral small vessel disease. The ocular vasculature is an anatomical extension of cerebral vessels, constituting part of the microv...
Lipid Ratio Biomarkers as Protective Factors for Depressive Symptoms in Newly Diagnosed Metabolic Syndrome: Evidence From Regression Modeling [0.03%]
新诊断的代谢综合征患者血脂比率生物标志物对抑郁症状的保护作用：来自回归模型的证据
Spas Kitov,Tanya Deneva,Maria-Florance Kitova et al.
Spas Kitov et al.
Background: Obesity and depression have a bidirectional relationship. Previous work has shown that obesity increases the risk of depression, while atypical depression can elevate the risk of obesity. This study aimed to i...
Astrocytes and Their Role in the Development and Progression of Alzheimer's Disease: Gatekeepers of Neurodegeneration [0.03%]
星形胶质细胞及其在阿尔茨海默病发生发展中的作用：神经变性调控者
Irena Svobodova,Zdenka Bendova,Jiri Novotny
Irena Svobodova
Astrocytes are increasingly recognized as central players in the pathogenesis of Alzheimer's disease (AD), exhibiting both neuroprotective and neurotoxic functions, which complicates their role in disease progression. Under physiological co...
Integrating Substantia Nigra Hyperechogenicity and Inflammation-Associated Biomarkers: A Classification Model for Staging Cognitive Impairment in Parkinson's Disease [0.03%]
黑质高回声与炎症相关生物标志物的整合：帕金森病认知障碍分期的分类模型
Jiahang Zhao,Chao Hou,Sen Wang et al.
Jiahang Zhao et al.
Background: Cognitive impairment (CI) is recognized as a debilitating complication of Parkinson's disease (PD). This study was designed to develop a diagnostic classification model by integrating substantia nigra hyperech...
Microglial Lipid Droplet Accumulation: A Pathological Nexus Between Obesity and Depression [0.03%]
小胶质细胞脂滴累积：肥胖和抑郁之间的病理联系
Xijin Liu,Jiacheng Chen,Yangzhi Xie et al.
Xijin Liu et al.
Background: A high-fat diet (HFD) has been implicated in the induction of depressive-like behaviors, yet the underlying mechanisms remain incompletely elucidated. Growing evidence indicates that microglia-mediated neuroin...
Differences in TMS-Induced Electric Fields Between Motor and Dorsolateral Prefrontal Cortices Revealed by Personalized Modeling [0.03%]
基于个性化头模的经颅磁刺激诱导的初级运动皮层和背外侧前额叶皮层电场分布比较研究
Yingpeng Wang,Yingqi Li,Hujun Wang et al.
Yingpeng Wang et al.
Background: To investigate whether the common clinical practice of setting transcranial magnetic stimulation (TMS) parameters by scaling from the motor threshold (MT) measured at the primary motor cortex (M1) can be expec...
The Role of T Cells in Multiple Sclerosis: Molecular Mechanisms, Drivers, and Therapeutic Targets [0.03%]
多发性硬化症中T细胞的作用：分子机制、驱动因素和治疗靶点
Pavel Potuznik,Jakub Vejskal,Ingrid Menkyova et al.
Pavel Potuznik et al.
Multiple sclerosis is a chronic immune-mediated disease of the central nervous system, marked by demyelination, axonal damage, and progressive neurological decline. T lymphocytes-particularly CD4+, T helper (Th)1 and Th17 cells, as well as ...