Effects and Mechanisms of Melatonin Receptor Agonist and Antagonist on Disease Progression in a 6-OHDA-Induced Parkinson's Disease Rat Model [0.03%]
促黑素受体激动剂和拮抗剂对6-OHDA诱导的帕金森病大鼠模型的影响及机制研究
Renxi Lin,Pengyang Liu,Weibin Lin et al.
Renxi Lin et al.
Background: Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration. Melatonin (MLT) is implicated in neuroprotection, yet the effects of modulating its receptors remain unclear. This study...
Gray Matter Volume Abnormalities in Stroke-free Atrial Fibrillation With and Without Mild Cognitive Impairment [0.03%]
无卒中的心房颤动患者（伴有或不伴有轻度认知障碍）的大脑灰质体积异常
Hongzhu Liu,Tong Li,Lin Li et al.
Hongzhu Liu et al.
Background: Individuals with atrial fibrillation (AF) are more likely to develop mild cognitive impairment (MCI), but the underlying mechanisms remain unclear. The study aimed to investigate cognitive-related gray matter ...
Pathophysiological Divergence Between Vascular and Post-Stroke Dementia: Bridging Human and Experimental Perspectives [0.03%]
血管性痴呆和卒中后痴呆的病理生理差异：连接人类和实验的视角
Ji Hyeon Ahn,Myoung Cheol Shin,Dae Won Kim et al.
Ji Hyeon Ahn et al.
Vascular dementia (VaD) and post-stroke dementia (PSD) are two leading subtypes of vascular cognitive impairment (VCI), each arising from distinct cerebrovascular pathologies. VaD typically results from chronic cerebral hypoperfusion and sm...
Dopaminergic and Opioid Systems Interact to Produce Peripheral Antinociception in Mice [0.03%]
多巴胺系统和阿片类系统相互作用产生小鼠外周镇痛效应
Bárbara F G Queiroz,Walace C P Barra,Flávia C S Fonseca et al.
Bárbara F G Queiroz et al.
Background: The overall pain experience results from the balance between the nociceptive pathway and the body's endogenous modulation of nociception. The interaction of these systems reduces nociception. Therefore, this s...
Poliumoside Alleviates Neuroinflammation and Oxidative Stress After Spinal Cord Injury by Activating the PI3K/AKT/mTOR Signaling Pathway [0.03%]
PI3K/AKT/mTOR信号通路活化抑制雪旺细胞氧化应激及炎症反应促进神经功能恢复
Qianqiu Li,Hongxiang Hong,Guanhua Xu et al.
Qianqiu Li et al.
Background: Spinal cord injury (SCI) constitutes a profoundly debilitating neurological disorder precipitating motor and sensory function impairment. Curtailing microglia-driven neuroinflammation alongside oxidative stres...
The Crucial Role of Cerebellar Crus I in Electroacupuncture Pretreatment for Attenuating Myocardial Ischemia-Reperfusion Injury [0.03%]
电针预处理通过减少小脑前叶 crus I 损伤减轻心肌缺血再灌注损伤
Yan Wu,Wen-Jing Shao,Hui-Min Chang et al.
Yan Wu et al.
Background: Electroacupuncture pretreatment (EA-pre) has been shown to help reduce myocardial ischemia-reperfusion injury (MIRI), but the underlying mechanism remains unclear. Our previous studies indicated that EA activa...
Herkinorin Promotes μ-Opioid Receptor Internalization and Protects iPSC-Derived Neurons from Hypoxic/Ischemic Injury [0.03%]
赫克尼奥促进μ-阿片受体内吞并保护诱导多能干细胞来源的神经元免受缺血缺氧性损伤
Zhihai Ju,Guyan Wang,Yanhong Yan et al.
Zhihai Ju et al.
Background: Hypoxic/ischemic brain injury remains a major clinical challenge, yet the cellular mechanisms linking oxygen-glucose deprivation/reperfusion (OGD/R) to opioid receptor regulation in human neurons are still not...
Exploring the Functional Connectivity of Resting-state EEG in Adolescent Major Depressive Disorder [0.03%]
探究青少年抑郁症静息态脑电功能连接改变
Yanna Kou,Yajing Si,Lu Liu et al.
Yanna Kou et al.
Background: This study aimed to explore the potential relationship between resting-state brain network attributes and adolescent major depressive disorder (MDD), with a focus on understanding how resting-state electroence...
FA-UNet: A FasterNet and Attention-Gated Hybrid Network for Precise Ischemic Stroke Segmentation [0.03%]
FA-UNet：一种更快的网络和注意力门控混合网络用于精确的缺血性卒中分割
Ishak Pacal,Ali Algarni,Bilal Bayram et al.
Ishak Pacal et al.
Background: Accurate and timely segmentation of ischemic stroke lesions from diffusion-weighted imaging (DWI) is crucial for diagnosis and treatment planning. Manual segmentation is labor-intensive, time-consuming, and pr...
Movement Sonification During Haptic Exploration Shifts Emotional Outcome Without Altering Texture Perception [0.03%]
触觉探索过程中动作声音化会改变情感结局而不会改变纹理感知
Laurence Mouchnino,Pierre-Henri Cornuault,Jenny Faucheu et al.
Laurence Mouchnino et al.
Background: Adding movement sonification to haptic exploration can change the perceptual outcome of a textured surface through multisensory processing. We hypothesized that auditory-evoked emotions influence the appraisal...