Preclinical Study of the Neuroprotective Effects of Pharmacological Agent-Modulators of HSP70 After Intrauterine Hypoxia [0.03%]
宫内缺氧后药物干预增敏HSP70的神经保护作用的实验研究
Igor Belenichev,Olena Aliyeva,Nina Bukhtiyarova et al.
Igor Belenichev et al.
Background: Chronic intrauterine hypoxia (IUH) is a cause not only of early postnatal mortality but also of delayed central nervous system (CNS) impairments in offspring, including increased risks of acute cerebrovascular...
Neurotrophic Factors in Stroke, Traumatic Brain Injury, and Neurodegeneration: A Convergent Pathophysiological and Translational Perspective [0.03%]
神经生长因子在卒中、创伤性脑损伤和神经退行性疾病中的作用：病理生理学和转化医学视角的汇聚
Olesya V Shcheblykina,Darya A Kostina,Mikhail V Pokrovskii et al.
Olesya V Shcheblykina et al.
Neurotrophic factors (NTFs), including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), glial cell line-derived neurotrophic factor (GDNF), ciliary neurotrophic factor (CNTF), and vascular endothel...
Dl-3-n-Butylphthalide Protects Human Brain Microvascular Endothelial Cells Against Ischemic Injury Through Dual Modulation of HIF1α/VEGF-Mediated Angiogenesis and COX2-Mediated Inflammation [0.03%]
DL-3-丁基苯酞通过HIF1α/VEGF介导的血管生成和COX2介导的炎症的双重调节保护人脑微血管内皮细胞免受缺血损伤
Yanyan Wang,Chuanxin Su,Teng Chen et al.
Yanyan Wang et al.
Background: Stroke remains a leading cause of death and disability worldwide. Endothelial dysfunction plays a central role in both acute ischemic injury and subsequent recovery. In this study, we investigated the protecti...
A Multi-Frequency Self-Supervised Fusion Model for EEG-Based Dementia Classification [0.03%]
一种基于EEG的多频自监督融合模型痴呆分类方法
Jinhua Sheng,Jiaqi Lin,Qiao Zhang et al.
Jinhua Sheng et al.
Background: Brain source localization technology enables precise characterization of the spatial distribution of neural activity, serving as a crucial tool for exploring the pathological mechanisms underlying dementia. Ho...
Shiyuan Lin,Zejing Lin,Ying Chen et al.
Shiyuan Lin et al.
Stroke has long been a leading cause of death and long-term disability worldwide. In recent years, more and more research has revealed that microglial responses to ischemic injury are highly heterogeneous and exhibit dynamic evolution over ...
Orexinergic-Opioidergic Interactions Within the Nucleus Accumbens in the Modulation of Acute Pain: Evidence From the Tail-Flick Test in Rats [0.03%]
下丘脑腹内侧神经核室 orexinergic-opioidergic 互作在急性疼痛调控中的作用：来自大鼠尾测痛实验的证据
Mohammad Sajad Jolani,Mahsa Mohammadi,Roghayeh Mozafari et al.
Mohammad Sajad Jolani et al.
Background: The nucleus accumbens (NAc) plays a central role in integrating motivational, reward-related, and nociceptive inputs. Opioid and orexin systems within the NAc are both implicated in pain modulation, yet their ...
Brain-Wide Connectivity of GLP1R Neurons in the Thalamic Reticular Nucleus [0.03%]
下丘脑视上核GLP1R神经元的全脑连接性研究
Xiao Zhang,Shanghui Zhu,Jiangzhong Lan et al.
Xiao Zhang et al.
Background: Glucagon-like peptide-1 receptor (GLP1R) is a G-protein-coupled receptor recognized for its essential role in metabolic homeostasis and insulin secretion. Emerging evidence suggests that central GLP-1 signalin...
Cancer Neuroscience of Kinase Inhibitors: On-Target Effects on the Nervous System [0.03%]
激酶抑制剂的癌症神经科学：对神经系统的作用机制研究
Thị Lam Thái,Sun-Young Han
Thị Lam Thái
Cancer neuroscience has emerged as a field that explores the bidirectional interactions between tumors and the nervous system. From this perspective, we review the pharmacological and neurobiological effects of kinase inhibitors, which are ...
Knockdown of Smox Protects Against Cerebral Ischemia/Reperfusion Injury by Suppressing Neuronal Autophagy via the AKT/AMPK/mTOR Phosphorylation Pathway [0.03%]
Smox敲低通过抑制神经元自噬缓解脑缺血再灌注损伤的机制研究
Zhihui Li,Qian Wang,Kaixuan Ma et al.
Zhihui Li et al.
Background: Stroke is a major cause of morbidity and mortality, characterized by neuronal damage and complex cell death pathways. This study aimed to investigate the protective role of spermine oxidase (Smox) in ischemic ...
Extracellular Vesicle-Mediated Delivery of VEGF and NGF Protects Dopaminergic Neurons in 6-OHDA-Induced Parkinson's Disease Models [0.03%]
外泌体介导的血管内皮生长因子和神经生长因子传递在6-羟基多巴胺诱导的帕金森病模型中的保护作用研究
Wenyu Yan,Xianyue Meng,Yan Wang et al.
Wenyu Yan et al.
Background: Parkinson's disease (PD) is a neurodegenerative disorder marked by motor dysfunction. No definitive methods exist to repair damaged neurons. Vascular endothelial growth factor (VEGF) and nerve growth factor (N...