Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research [0.03%]
尼古丁乙酰胆碱受体的遗传多态性与烟草依赖：来自人类和动物研究的一致证据
George S Portugal,Thomas J Gould
George S Portugal
Tobacco smoking is a leading preventable cause of death in the United States and produces a major health and economic burden. Although the majority of smokers want to quit, few are successful. These data highlight the need for additional re...
Casein kinase I epsilon (CKIvarepsilon) N408 allele is very rare in the Brazilian population and is not involved in susceptibility to circadian rhythm sleep disorders [0.03%]
巴西人群中的钙调神经磷酸酶Iepsilon(N408)基因型非常罕见且与昼夜节律睡眠障碍无关
Rosa M R P S Castro,Ana A Barbosa,Mario Pedrazzoli et al.
Rosa M R P S Castro et al.
Circadian rhythms are regulated by clock proteins through post-translational modifications. Indeed, Casein kinase I epsilon (CKIvarepsilon) promotes reversible phosphorylation of PER proteins, and a deficiency in this phosphorylation has be...
Hitoshi Sasaki,Sadatsugu Sakane,Takuya Ishida et al.
Hitoshi Sasaki et al.
The present study aimed to demonstrate stochastic resonance (SR) for a visual signal above the threshold by using a two-alternative forced-choice protocol. The percent correct response enhanced at non-zero intensity of noise, while decrease...
The amygdala and emotional modulation of competition between cognitive and habit memory [0.03%]
杏仁体与认知记忆和习惯记忆间竞争的emotion调节
Jeffrey C Wingard,Mark G Packard
Jeffrey C Wingard
The basolateral amygdala (BLA) is implicated in the neurobiology of emotion, and can also modulate the cognitive and habit memory processes mediated by the hippocampus and dorsal striatum, respectively. In a dual-solution task that can be a...
Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey [0.03%]
不可预测慢性轻度应激小鼠品系差异的抗抑郁药筛查研究
Ipek Yalcin,Catherine Belzung,Alexandre Surget
Ipek Yalcin
There have been few comparisons of strains and antidepressants in the unpredictable chronic mild stress (UCMS) paradigm in mice. This study was undertaken to determine the influence of such factors using four antidepressants drugs including...
A combined [11C]diprenorphine PET study and fMRI study of acupuncture analgesia [0.03%]
联合运用[11C]二氢 codeine 受体PET和痛刺激功能磁共振研究针刺镇痛机制
Darin D Dougherty,Jian Kong,Megan Webb et al.
Darin D Dougherty et al.
Functional neuroimaging studies suggest that a lateral network in the brain is associated with the sensory aspects of pain perception while a medial network is associated with affective aspects. The highest concentration of opioid receptors...
Deficient associative learning in drug-naive first-episode schizophrenia: results obtained using a new visual within-subjects learned irrelevance paradigm [0.03%]
用药前首次发病的 schizophrenic患者合情推理学习能力缺陷：利用新型视觉受试内学习无关范式得出的结果
Ariane T Orosz,Joram Feldon,Gilad Gal et al.
Ariane T Orosz et al.
One of the key features of schizophrenia is the inability to filter out irrelevant stimuli which consequently leads to stimulus overload. There are different methods which aim at investigating these deficient filter mechanisms; one of these...
Comparing the benefits of caffeine, naps and placebo on verbal, motor and perceptual memory [0.03%]
关于咖啡因、短暂睡眠以及安慰剂对语言记忆、运动记忆和感知记忆的影响的比较研究
Sara C Mednick,Denise J Cai,Jennifer Kanady et al.
Sara C Mednick et al.
Caffeine, the world's most common psychoactive substance, is used by approximately 90% of North Americans everyday. Little is known, however, about its benefits for memory. Napping has been shown to increase alertness and promote learning o...
Randomized Controlled Trial
Behavioural brain research. 2008 Nov 3;193(1):79-86. DOI:10.1016/j.bbr.2008.04.028 2008
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration [0.03%]
关于应激控制力和背缝核在糖水偏爱和社会探究中的作用研究
John P Christianson,Evan D Paul,Myra Irani et al.
John P Christianson et al.
Research investigating how control over stressors affects behavior often utilizes freezing and shuttle escape learning as the behavioral endpoints. These endpoints have been argued to reflect anxious or depressed states, but these descripti...
Serotonin modulates vocalizations and territorial behavior in an amphibian [0.03%]
血清素通过调节鸣叫和领地行为调控两栖类的繁殖活动
Gary R Ten Eyck
Gary R Ten Eyck
It is well established that the serotonergic system modulates social and aggressive behaviors. This study employed field experiments to examine the effects of serotonin on male social structure and behavior in the Puerto Rican coquí frog, ...