Effects of urokinase-type plasminogen activator in the acquisition, expression and reinstatement of cocaine-induced conditioned-place preference [0.03%]
尿激酶型纤溶酶原激活物在可卡因诱导的条件位置偏爱的获得、表达和复现中的作用
Amine Bahi,Alexander W Kusnecov,Jean-Luc Dreyer
Amine Bahi
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, ...
Chronic, low-dose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57/B6 mice [0.03%]
低剂量孕期甲基汞暴露可损害C57/B6小鼠成年期的运动和记忆功能
Karienn S Montgomery,Jessica Mackey,Kerry Thuett et al.
Karienn S Montgomery et al.
Methylmercury (MeHg) has cytotoxic effects on animals and humans, and a major target organ for MeHg is the central nervous system (CNS). It is well known that the developing CNS is extremely vulnerable to MeHg-induced changes in comparison ...
Performance of spontaneously hypertensive rats in a peak-interval procedure with gaps [0.03%]
自发性高血压大鼠在带间隔的峰值间期操作中的表现
Vladimir Orduña,Ana García,Marina Menez et al.
Vladimir Orduña et al.
The purpose of the present experiment was to evaluate timing behavior in spontaneously hypertensive rats (SHR), and compare it to the performance of Wistar Kyoto (WKY), and Wistar (WI) rats. In the first phase of the experiment, the subject...
Iris Mueller,Carolin Gall,Erich Kasten et al.
Iris Mueller et al.
Purpose: Systematic vision restoration training has been shown to improve the detection performance of brain-damaged patients with visual-field defects. So far, patients have been trained daily up to 6 months. We wished t...
Blockade of group II, but not group I, mGluRs in the rat nucleus accumbens inhibits the expression of conditioned hyperactivity in an amphetamine-associated environment [0.03%]
纹状体外侧核Ⅱ型而非I型代谢型谷氨酸受体拮抗剂抑制环境诱导的安非他明条件作用所致的大鼠过度活动行为
Wha Young Kim,Paul Vezina,Jeong-Hoon Kim
Wha Young Kim
Environmental stimuli associated with amphetamine (AMPH) can elicit conditioned locomotion in rats, and the nucleus accumbens (NAcc) is known to be important in this process. This study examined the contribution of metabotropic glutamate re...
ERalpha, but not ERbeta, mediates the expression of sexual behavior in the female rat [0.03%]
雌性大鼠的性行为由ERalpha而不是ERbeta介导表达
Christine A Mazzucco,Hope A Walker,Jodi L Pawluski et al.
Christine A Mazzucco et al.
Estrogen has well known effects on sexual behavior, however the role of the estrogen receptors (ER) alpha and beta on sexual behavior remains to be fully determined. This study investigated the individual and co-operative involvement of ERa...
Effects of the genetic background on cognitive performances of TG2576 mice [0.03%]
遗传背景对tg2576小鼠认知表现的影响
Jean Michel Lassalle,Hélène Halley,Stéphanie Daumas et al.
Jean Michel Lassalle et al.
Animal models of genetic diseases obtained by transferring human mutated genes in the mouse are widely used in biomedical based research. They constitute efficient tools to study mechanisms underlying abnormal phenotypes. Unfortunately, the...
Antidepressant-like effect of lamotrigine is reversed by veratrine: a possible role of sodium channels in bipolar depression [0.03%]
拉莫三嗪的抗抑郁作用被 Veronica 翻转：双相情感障碍中钠通道的可能作用
Corina Prica,Martine Hascoet,Michel Bourin
Corina Prica
Lamotrigine has been found to be efficacious in the acute management of bipolar depression and long-term management of bipolar disorder, especially in delaying depressive recurrence, either as monotherapy or as adjunctive therapy. Lamotrigi...
Effects of environmental enrichment on exploration, anxiety, and memory in female TgCRND8 Alzheimer mice [0.03%]
环境富养对阿尔茨海默病Tgcrnd8模型小鼠的探索、焦虑以及记忆的影响
Nicole Görtz,Lars Lewejohann,Manuel Tomm et al.
Nicole Görtz et al.
After we could recently demonstrate a beneficial effect of environmental enrichment on AD-like brain pathology in female TgCRND8 mice [Ambrée O, Leimer U, Herring A, Görtz N, Sachser N, Heneka MT, et al. Reduction of amyloid angiopathy an...
Matthew Parker,Edward S Redhead,Deborah Goodwin et al.
Matthew Parker et al.
Horses displaying an oral stereotypy were tested on an instrumental choice paradigm to examine differences in learning from non-stereotypic counterparts. Stereotypic horses are known to have dysfunction of the dorsomedial striatum, and lesi...