Experimental and clinical evidence of the role of cytokines and growth factors in the pathogenesis of acquired cobalamin-deficient leukoneuropathy [0.03%]
细胞因子和生长因子在获得性维生素B12缺乏性白细胞神经病发病机制中作用的实验和临床证据
Giuseppe Scalabrino,Daniela Veber,Elena Mutti
Giuseppe Scalabrino
Our experimental and clinical studies have highlighted the non-coenzyme functions of cobalamin (Cbl; vitamin B12). The neuropathy of the rat central nervous system (CNS) due to Cbl deficiency is associated with increases in CNS tissue and/o...
Diffusion-weighted magnetic resonance imaging demonstrates parenchymal pathophysiological changes in epilepsy [0.03%]
弥散加权MRI显示癫痫患者的脑皮层病理生理变化
Jin-Tai Yu,Lan Tan
Jin-Tai Yu
Diffusion-weighted magnetic resonance imaging (DW-MRI) is a novel noninvasive technique probing the Brownian motion of water molecules. It has already proved very useful in the early identification of cerebral ischemia in human patients. Al...
Neuroprotective properties and mechanisms of erythropoietin in in vitro and in vivo experimental models for hypoxia/ischemia [0.03%]
人和实验动物缺血/缺氧模型中促红细胞生成素的神经保护作用及机制研究
Michael A van der Kooij,Floris Groenendaal,Annemieke Kavelaars et al.
Michael A van der Kooij et al.
Besides its established function in erythropoiesis, erythropoietin (EPO) is currently also appreciated for its neuroprotective effects. The detrimental sequelae of prolonged cerebral hypoxia and ischemia have been shown to attenuate by EPO ...
Adaptive properties and heterogeneity of dopamine D(2) receptors - pharmacological implications [0.03%]
多巴胺D2受体的适应性特征及异质性-药理学意义
Arvid Carlsson,Maria L Carlsson
Arvid Carlsson
In this review, we focus on the marked adaptability of dopamine D(2) receptors to varying agonist levels and we discuss the extent to which this phenomenon can account for the heterogeneity of these receptors in regard to function and pharm...
Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington's disease [0.03%]
磁共振成像作为一种识别亨廷顿病神经病理生物标志物的方法
India Bohanna,Nellie Georgiou-Karistianis,Anthony J Hannan et al.
India Bohanna et al.
Magnetic Resonance Imaging (MRI), functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) have been central to characterisation of abnormalities in brain structure and function in both clinical and preclinical Huntington's disease (HD). On...
Carl Y Saab,Stephen G Waxman,Bryan C Hains
Carl Y Saab
The nociceptive nervous system and the immune system serve to defend and alarm the host of imminent or actual damage. However, persistent or recurring exposure of neurons to activated immune cells is associated with an increase in painful b...
Ee Ling Ng,Bor Luen Tang
Ee Ling Ng
The Rab family of small GTPases serves as cellular regulators of vesicular transport in all eukaryotes. Higher organisms have a vastly expanded number of Rabs. Some of these would presumably perform cell-type or tissue-specific functions. R...
Kjell G Fuxe,Alexander O Tarakanov,Larisa B Goncharova et al.
Kjell G Fuxe et al.
Common architecture of cytokine receptors and G-protein coupled receptors (GPCRs) may underlie pathological receptor heteromer formation and signaling. Here, we clarify how chemokines and cytokines can participate in pathogenic processes of...
Global profiling of influence of intra-ischemic brain temperature on gene expression in rat brain [0.03%]
缺血过程中脑温度对基因表达影响的全球分析
Megumi Sugahara Kobayashi,Satoshi Asai,Koichi Ishikawa et al.
Megumi Sugahara Kobayashi et al.
Mild to moderate differences in brain temperature are known to greatly affect the outcome of cerebral ischemia. The impact of brain temperature on ischemic disorders has been mainly evaluated through pathological analysis. However, no compr...
Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugs [0.03%]
阿片类和兴奋性精神活性物质的神经毒性机制研究进展
Teresa Cunha-Oliveira,Ana Cristina Rego,Catarina R Oliveira
Teresa Cunha-Oliveira
Substance abuse and addiction are the most costly of all the neuropsychiatric disorders. In the last decades, much progress has been achieved in understanding the effects of the drugs of abuse in the brain. However, efficient treatments tha...