Descending control of nociception: Specificity, recruitment and plasticity [0.03%]
疼痛下行调控：特异性、招募和可塑性
M M Heinricher,I Tavares,J L Leith et al.
M M Heinricher et al.
The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and as such, offers a very powerful target for regulation of nociceptive transmission by both local segmental and supraspinal mechanisms. Descending c...
Cyril Goudet,Valerio Magnaghi,Marc Landry et al.
Cyril Goudet et al.
Glutamate and gamma-amino butyric acid (GABA) are respectively two major excitatory and inhibitory neurotransmitters of the adult mammalian central nervous system. These neurotransmitters exert their action through two types of receptors: i...
Catherine Abbadie,Sonia Bhangoo,Yves De Koninck et al.
Catherine Abbadie et al.
The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie the development of these chronic pain syndromes. It is now well established that astrocyt...
The R6 lines of transgenic mice: a model for screening new therapies for Huntington's disease [0.03%]
亨廷顿舞蹈病治疗筛选的转基因小鼠模型
Joana M Gil,A Cristina Rego
Joana M Gil
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene that results in cortical and striatal degeneration, and mutant huntingtin aggregation. Current treatments are unsatisfactor...
Cajal's second great battle for the neuron doctrine: the nature and function of neurofibrils [0.03%]
卡哈尔第二次为了神经元学说而战：神经纤维的性质与功能
Eugenio Frixione
Eugenio Frixione
One hundred years ago, a novel kind of reticularism threatened to displace the neuron doctrine as the established model of functional organization of the nervous system. The challenging paradigm, championed by Stephan von Apáthy and Albrec...
Mark F Mehler,Dominick P Purpura
Mark F Mehler
Some children with autism spectrum disorders (ASD) exhibit improved behaviors and enhanced communication during febrile episodes. We hypothesize that febrigenesis and the behavioral-state changes associated with fever in autism depend upon ...
Neurogliogenesis in the mature olfactory system: a possible protective role against infection and toxic dust [0.03%]
成熟的嗅觉系统中的神经胶质发生作用可能具有抵抗感染和有毒尘埃的保护作用
Elena Loseva,Ti-Fei Yuan,Sergei Karnup
Elena Loseva
The outpost position of the olfactory bulb (OB) between the direct inputs from sensory neurons of the nasal epithelium and other parts of the brain suggests its highest vulnerability among all brain structures to penetration of exogenous ag...
Zinc and cortical plasticity [0.03%]
锌与皮质可塑性
Amy S Nakashima,Richard H Dyck
Amy S Nakashima
The divalent cation zinc is an essential element, having both universal and specified functions throughout the body. In the mammalian telencephalon, zinc has extensive effects on neurotransmission, affecting receptor function and second mes...
Involvement of NOS/NO in the development of chronic dental inflammatory pain in rats [0.03%]
大鼠慢性牙周炎痛觉过敏的病理机制研究进展及干预措施国内外研究现状分析——诱导型一氧化氮合酶/一氧化氮信号通路的作用
Wenguo Fan,Fang Huang,Cuixia Li et al.
Wenguo Fan et al.
Nitric oxide (NO) is believed to be an important messenger molecule in nociceptive transmission. To assess the possible roles of NO in trigeminal sensory system, we examined the distribution and density of histochemical staining for nicotin...
Regulation of ceramide-induced neuronal death: cell metabolism meets neurodegeneration [0.03%]
鞘氨醇诱导的神经元死亡的调节：细胞代谢与神经退行性病变相遇
Gonzalo Arboleda,Luis Carlos Morales,Bruno Benítez et al.
Gonzalo Arboleda et al.
The present review explores the role of ceramides in neuronal apoptosis, as well as the recent discovery of the signaling pathways involved in this process placing particular emphasis on the correlation between cellular metabolism and neuro...