Gerald W Zamponi,Richard J Lewis,Slobodan M Todorovic et al.
Gerald W Zamponi et al.
Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in primary afferent neurons. N-type calcium channels are localized to synaptic nerve terminals in laminae 1 and 2 of the dorsal horn where their opening r...
Mechanisms of chronic central neuropathic pain after spinal cord injury [0.03%]
脊髓损伤后慢性中枢神经病理性疼痛的发病机制
Claire E Hulsebosch,Bryan C Hains,Eric D Crown et al.
Claire E Hulsebosch et al.
Not all spinal contusions result in mechanical allodynia, in which non-noxious stimuli become noxious. The studies presented use the NYU impactor at 12.5 mm drop or the Infinite Horizons Impactor (150 kdyn, 1 s dwell) devices to model spina...
Voltage-gated sodium channels in pain states: role in pathophysiology and targets for treatment [0.03%]
疼痛状态下电压门控钠通道的病理生理作用及其治疗靶点
Sulayman D Dib-Hajj,Alexander M Binshtok,Theodore R Cummins et al.
Sulayman D Dib-Hajj et al.
Pain is a major unmet medical need which has been causally linked to changes in sodium channel expression, modulation, or mutations that alter channel gating properties or current density in nociceptor neurons. Voltage-gated sodium channels...
Frank Porreca,Todd W Vanderah
Frank Porreca
Guy Hans,Brian L Schmidt,Gary Strichartz
Guy Hans
The endogenous peptide endothelin-1 (ET-1), originally identified as a potent vasoconstrictor, plays a role in a number of painful conditions. In this review article we discuss the mechanisms that are essential for local sensitization by su...
Christoph Stein,J David Clark,Uhtaek Oh et al.
Christoph Stein et al.
This review summarizes recent findings on peripheral mechanisms underlying the generation and inhibition of pain. The focus is on events occurring in peripheral injured tissues that lead to the sensitization and excitation of primary affere...
MAP kinase and pain [0.03%]
MAP激酶与疼痛
Ru-Rong Ji,Robert W Gereau th,Marzia Malcangio et al.
Ru-Rong Ji et al.
Mitogen-activated protein kinases (MAPKs) are important for intracellular signal transduction and play critical roles in regulating neural plasticity and inflammatory responses. The MAPK family consists of three major members: extracellular...
Therapeutic potential of vanilloid receptor TRPV1 agonists and antagonists as analgesics: Recent advances and setbacks [0.03%]
辣椒素受体TRPV1激动剂和拮抗剂作为镇痛药的治疗潜力：最近的进步与挫折
Gilbert Y Wong,Narender R Gavva
Gilbert Y Wong
The vanilloid receptor TRPV1 is a homotetrameric, non-selective cation channel abundantly expressed in the nociceptors (c-fibers). TRPV1 is considered as a highly validated pain target because, i) its agonists such as capsaicin cause desens...
Julie A Christianson,Klaus Bielefeldt,Christophe Altier et al.
Julie A Christianson et al.
Visceral pain is the most common reason for doctor visits in the US. Like somatic pain, virtually all visceral pain sensations begin with the activation of primary sensory neurons innervating the viscera and/or the blood vessels associated ...
Targeting CB2 receptors and the endocannabinoid system for the treatment of pain [0.03%]
靶向CB2受体和内源大麻素系统治疗疼痛
Praveen Anand,Garth Whiteside,Christopher J Fowler et al.
Praveen Anand et al.
The endocannabinoid system consists of the cannabinoid (CB) receptors, CB(1) and CB(2), the endogenous ligands anandamide (AEA, arachidonoylethanolamide) and 2-arachidonoylglycerol (2-AG), and their synthetic and metabolic machinery. The us...