Cheryl L Stucky,Adrienne E Dubin,Nathaniel A Jeske et al.
Cheryl L Stucky et al.
Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that dete...
G Dussor,H R Koerber,A L Oaklander et al.
G Dussor et al.
Sensory neurons that innervate the skin provide critical information about physical contact between the organism and the environment, including information about potentially-damaging stimuli that give rise to the sensation of pain. These af...
Predicting therapeutic efficacy - experimental pain in human subjects [0.03%]
预测治疗效果在人类受试者身上的实验性疼痛中的应用
Boris A Chizh,Tony Priestley,Michael Rowbotham et al.
Boris A Chizh et al.
The pharmaceutical industry faces tough times. Despite tremendous advances in the science and technology of new lead identification and optimization, attrition rates for novel drug candidates making it into the clinic remain unacceptably hi...
Cognitive motor processes: the role of motor imagery in the study of motor representations [0.03%]
认知运动过程：运动表象在运动表现研究中的作用
Jörn Munzert,Britta Lorey,Karen Zentgraf
Jörn Munzert
Motor imagery is viewed as a window to cognitive motor processes and particularly to motor control. Mental simulation theory [Jeannerod, M., 2001. Neural simulation of action: a unifying mechanism for motor cognition. NeuroImage 14, 103-109...
Theodore J Price,Fernando Cervero,Michael S Gold et al.
Theodore J Price et al.
Melzack and Wall's Gate Control Theory of Pain laid the theoretical groundwork for a role of spinal inhibition in endogenous pain control. While the Gate Control Theory was based on the notion that spinal inhibition is dynamically regulated...
Ke Ren,Richard Torres
Ke Ren
The cytokine cascade in pain and inflammatory processes is a tremendously complex system, involving glial, immune, and neuronal cell interactions. IL-1beta is a pro-inflammatory cytokine that has been implicated in pain, inflammation and au...
Susan E Bove,Sarah J L Flatters,Julia J Inglis et al.
Susan E Bove et al.
Non-malignant musculoskeletal pain is the most common clinical symptom that causes patients to seek medical attention and is a major cause of disability in the world. Musculoskeletal pain can arise from a variety of common conditions includ...
Markus Butz,Florentin Wörgötter,Arjen van Ooyen
Markus Butz
Plasticity in the brain reaches far beyond a mere changing of synaptic strengths. Recent time-lapse imaging in the living brain reveals ongoing structural plasticity by forming or breaking of synapses, motile spines, and re-routing of axona...
Jill C Fehrenbacher,Jesse Loverme,William Clarke et al.
Jill C Fehrenbacher et al.
We discuss and present new data regarding the physiological and molecular mechanisms of nuclear receptor activation in pain control, with a particular emphasis on non-genomic effects of ligands at peroxisome proliferator-activated receptor ...
Forebrain pain mechanisms [0.03%]
前脑痛机制
Volker Neugebauer,Vasco Galhardo,Sabatino Maione et al.
Volker Neugebauer et al.
Emotional-affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain...