Paediatric Reference Intervals: Current Status, Gaps, Challenges and Future Considerations [0.03%]
儿科参考区间：现状、空白、挑战和未来考虑因素
Monsurul Hoq,Susan Matthews,Susan Donath et al.
Monsurul Hoq et al.
Establishing paediatric reference intervals (RIs) is a challenging task due to difficulties in subject recruitment, collection of adequate blood volume, and the inherent physiological changes of many biomarkers with age. Despite these chall...
Subashini C Thambiah,Swan Sim Yeap
Subashini C Thambiah
Osteoporosis (OP) is a condition where there is low bone density and microarchitectural deterioration which can predispose to fragility fractures. There is a wealth of literature on OP from the developed countries, but less so from Asia. Th...
Jean Pierre Salles
Jean Pierre Salles
Hypophosphatasia (HPP) is a rare inherited systemic metabolic disease caused by mutations in the tissue-nonspecific alkaline phosphatase (TNSALP) gene. TNSALP is expressed in the liver, kidney and bone, and its substrates include TNSALP ino...
Andrew St John
Andrew St John
The pressure on healthcare budgets including laboratory medicine is relentless and the focus on activities and costs remains the dominant funding model of laboratory medicine everywhere. The limitations of this model are well documented and...
Revisiting the Biological Variability of Cardiac Troponin: Implications for Clinical Practice [0.03%]
重新审视心脏肌钙蛋白的生物变异性：对临床实践的影响
Nick S R Lan,Damon A Bell
Nick S R Lan
The diagnosis of acute myocardial injury requires a rise and/or fall of cardiac troponin (cTn) on serial testing, with at least one concentration above the 99th percentile value of a normal reference population according to the recently pub...
Practical Aspects in Genetic Testing for Cardiomyopathies and Channelopathies [0.03%]
cardiomyopathy和通道病基因检测的实践方面
Han-Chih Hencher Lee,Chor-Kwan Ching
Han-Chih Hencher Lee
Genetic testing has an increasingly important role in the diagnosis and management of cardiac disorders, where it confirms the diagnosis, aids prognostication and risk stratification and guides treatment. A genetic diagnosis in the proband ...
Superwarfarin (Long-Acting Anticoagulant Rodenticides) Poisoning: from Pathophysiology to Laboratory-Guided Clinical Management [0.03%]
超华法林（长效抗凝灭鼠药）中毒：从发病机制到实验室指导的临床处理
Yeow-Kuan Chong,Tony Wing-Lai Mak
Yeow-Kuan Chong
Superwarfarins are long-acting anticoagulant rodenticides developed from warfarin. The mechanism of action is by inhibition of vitamin K epoxide reductase, resulting in the inability of the body to recycle vitamin K. Deficiency of vitamin K...
Matthew Burke
Matthew Burke
Carbohydrate intolerance is one of several syndromes and diseases which together are known as malabsorption syndromes. These include small intestinal bacterial overgrowth (SIBO), coeliac disease, intestinal lymphangiectasia, short bowel syn...
Systematic Review of the Effects of Ultraviolet Radiation on Markers of Metabolic Dysfunction [0.03%]
紫外线辐射对代谢紊乱标志物影响的系统评价研究
Shelley Gorman,Barbora de Courten,Robyn M Lucas
Shelley Gorman
Emerging findings suggest that exposure to ultraviolet wavelengths of sunlight modulates metabolic function. Here we review the metabolic effects of exposure to ultraviolet radiation (UVR), focusing on the effects of phototherapies (that ad...
Quadrupole Time-of-Flight Mass Spectrometry: A Paradigm Shift in Toxicology Screening Applications [0.03%]
四极杆飞行时间质谱在毒物筛查中的应用：一场变革式的转变
Darren R Allen,Brett C McWhinney
Darren R Allen
The screening of biological samples for the presence of illicit or legal substances is an important frontline tool in both clinical and forensic toxicology. In the clinical setting, drug screening is a useful tool for the clinician in impro...