E Meyer,G Cole,R Radhakrishnan et al.
E Meyer et al.
The structure of native porcine pancreatic elastase in 70% methanol has been refined using film data to 1.65 A resolution, R = 0.169. A total of 134 molecules of water (but no methanol) has been refined. This structure, because of its nativ...
Cryocrystallography of biological macromolecules: a generally applicable method [0.03%]
生物大分子的冰晶学：一种通用的方法
H Hope
H Hope
Methods have been developed that allow facile X-ray data collection for biological macromolecules at cryogenic (near liquid N2) temperatures. The crystals are first transferred from their mother liquor to a hydrocarbon environment, then mou...
A Wlodawer,H Savage,G Dodson
A Wlodawer
Neutron diffraction data for porcine 2Zn insulin were collected to 2.2 A resolution from a single crystal deuterated by slow exchange of mother liquor. A joint neutron/X-ray restrained-least-squares refinement was undertaken using the neutr...
Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c [0.03%]
基于分子动力学的晶体学优化方法研究：热稳定丝氨酸蛋白酶thermitase与eglin c复合物的研究
P Gros,M Fujinaga,B W Dijkstra et al.
P Gros et al.
In order to investigate the principles of protein thermostability, the crystal structure of thermitase from Thermoactinomyces vulgaris, a thermostable member of the subtilisin family of serine proteases, has been determined in a complex wit...
The structures of 1-deoxy-(N-methyloctanamido)-D-glucitol (MEGA-8) and 1-deoxy-(N-methylundecanamido)-D-glucitol (MEGA-11) [0.03%]
1-脱氧-N-甲基辛酰氨基-D-葡萄醇（MEGA-8）和1-脱氧-N-甲基十一烷酰氨基-D-葡萄醇（MEGA-11）的结构式
G A Jeffrey,H Maluszynska
G A Jeffrey
1-Deoxy-(N-methyloctanamido)-D-glucitol, C15H31NO6 (MEGA-8), crystallizes in space group P2(1)2(1)2(1), Mr = 321.4, a = 4.865 (1), b = 9.186 (3), c = 39.097 (9) A, V = 1747.24 A3, Z = 4, Dx = 1.22 Mg m-3, lambda (Cu K alpha) = 1.5418 A, mu ...
A comparison of the crystal structures of some quaternary trimethylammonium salts related to dopamine and noradrenaline with those of the corresponding amines: a comment on their nicotine-like biological activities [0.03%]
一些与多巴胺和去甲肾上腺素相关的四元三甲铵盐的晶体结构与其相应的仲胺的比较及其类尼古丁生物活性的评述
R B Barlow,O Johnson,J A Howard et al.
R B Barlow et al.
The crystal structures of seven substituted phenethylammonium salts and one (phenylpropyl)-ammonium salt have been determined. (I) Trimethyl(phenethyl)ammonium iodide, C11H18N+.I-, Mr = 291.2, orthorhombic, P2(1)2(1)2(1) (No. 19), a = 6.040...
Structural studies on the biosides of Digitalis lanata: bisdigitoxosides of digitoxigenin, gitoxigenin and digoxigenin [0.03%]
铃兰苷元的双糖苷的研究——铃兰毒苷元、毛花洋地黄苷元及地高辛苷元的生物侧链的结构研究
K T Go,K K Bhandary
K T Go
The crystal structures and conformations of bisdigitoxosides of digitoxigenin (I), gitoxigenin (II) and digoxigenin (III and IV) have been determined using single-crystal X-ray crystallographic techniques. Crystals of (I), (II) and (IV) wer...
Crystal structure of 1-methyluracil from neutron diffraction at 15, 60 and 123 K [0.03%]
基于低温中子衍射的1-甲基尿嘧啶晶体结构测定
R K McMullan,B M Craven
R K McMullan
The crystal structure of 1-methylpyrimidine-2,4-dione (1-methyluracil, C5H6N2O2) has been determined at 15, 60 and 123 K from neutron diffraction data. Molecules lie in the eightfold special positions (symmetry m) of space group Ibam, with ...
H Hope,F Frolow,K von Böhlen et al.
H Hope et al.
Crystals suitable for X-ray study have been prepared from biochemically active ribosome particles or their complexes with tRNA and polypeptide chains. At ambient temperature the useful lifetime of these crystals under synchrotron irradiatio...
Structure-activity relationships of antiarrhythmic agents: crystal structure of amiodarone hydrochloride and two derivatives, and their conformational comparison with thyroxine [0.03%]
抗心率失常药的构效关系：胺碘酮盐酸盐及其两种衍生物的晶体结构与甲状腺素的空间构象比较
V Cody,J Luft
V Cody
Amiodarone.HCl (I), 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride, C25H30I2NO3+.Cl-, Mr = 680.78, monoclinic, P2(1)/c, a = 17.124 (2), b = 17.079 (2), c = 9.162 (1) A, beta = 98.37 degrees, V = 2651...