Enhancer Arrays Regulating Developmental Genes: Sox2 Enhancers as a Paradigm [0.03%]
调控发育基因的增强子阵列：Sox2 增强子为例证
Hisato Kondoh
Hisato Kondoh
Enhancers are the primary regulatory DNA sequences in eukaryotes and are mostly located in the non-coding sequences of genes, namely, intergenic regions and introns. The essential characteristic of an enhancer is the ability to activate pro...
Hisato Kondoh
Hisato Kondoh
Encountering a developmental process confined to a limited time window or a restricted embryonic area, one may deem that the mechanism to activate the process occurs with such precision in temporal and spatial terms. However, in many instan...
Reciprocal Interactions Between the Epithelium and Mesenchyme in Organogenesis [0.03%]
上皮与间充质在器官发生中的相互作用
Hisato Kondoh
Hisato Kondoh
Many organs are composed of epithelial and mesenchymal tissue components. These two tissue component types develop via reciprocal interactions. However, for historical and technical reasons, the effects of the mesenchymal components on the ...
Hisato Kondoh
Hisato Kondoh
The classic conception of tissue regeneration assumed the existence of tissue-proper regeneration stem cells that are set aside during normal tissue development and reserved as stem cells for regeneration. However, modern studies using cell...
Hisato Kondoh
Hisato Kondoh
It has long been assumed that a specific cell type arises following stepwise specification of cells corresponding to the branching of cell lineages. However, accumulating evidence indicates that multiple and even remote cell lineages can le...
Hisato Kondoh
Hisato Kondoh
Studies using early-stage avian embryos have substantially impacted developmental biology, through the availability of simple culture methods and easiness in tissue manipulation. However, the regulations underlying brain and head developmen...
Hisato Kondoh
Hisato Kondoh
As epiblast cells initiate development into various somatic cells, they undergo a large-scale reorganization, called gastrulation. The gastrulation of the epiblast cells produces three groups of cells: the endoderm layer, the collection of ...
Different Types of Pluripotent Stem Cells Represent Different Developmental Stages [0.03%]
不同类型的多能干细胞代表不同的发育阶段
Hisato Kondoh
Hisato Kondoh
Pluripotent stem cell lines established from early-stage embryos of mammals or other species represent the embryonic stages before the initiation of somatic development. In these stem cell lines, cell proliferation capacity is maintained wh...
Hisato Kondoh
Hisato Kondoh
All somatic cells develop from the epiblast, which occupies the upper layer of two-layered embryos and in most mammals is formed after the implantation stage but before gastrulation initiates. Once the epiblast is established, the epiblast ...
Ranish K Patel,Michael Parappilly,Shahrose Rahman et al.
Ranish K Patel et al.
While tumor metastases represent the primary driver of cancer-related mortality, our understanding of the mechanisms that underlie metastatic initiation and progression remains incomplete. Recent work identified a novel tumor-macrophage hyb...