Devonique Brissett-Lasalle,Zoya Syed,Yashitha Yarubandi et al.
Devonique Brissett-Lasalle et al.
Silent information regulator 1 (SIRT1), a conserved lysine deacetylase, is an important contributor to the function of macrophages, which are the scavengers of the innate immune system. Macrophages are part of the first line of defense agai...
Acetylation in Cardiac Aging: Molecular Mechanism and Therapeutic Approaches [0.03%]
心肌衰老中的乙酰化：分子机制与治疗策略
Aditi Dattatraya Hase,Sanjay K Banerjee
Aditi Dattatraya Hase
This chapter highlights the hallmarks of cardiac aging, distinguishing characteristics between cardiac aging and cardiac senescence. An overview of the molecular mechanisms underlying cardiac aging, with a particular focus on the role of re...
Impact of Histone Acetyltransferases and Histone Deacetylases on Adult Brain Myelin Plasticity [0.03%]
组蛋白乙酰转移酶和组蛋白脱乙酰基酶对成人脑髓鞘可塑性的影响
Alessandra Dominicis,Tommaso Fabiano,Simone Peria et al.
Alessandra Dominicis et al.
Myelin plasticity is a key process for acquiring new motor skills and preventing neurodegeneration during ageing. Neural precursor cells (NPCs) and parenchymal oligodendrocyte precursor cells (OPCs) play a key role in myelin plasticity in t...
Epigenetic Echoes: Decoding the Acetylation Journey from Neural Crest to Melanocyte [0.03%]
表观遗传印记：神经嵴到黑素细胞乙酰化旅程的解码
Ayesha Nasreen,Sribas Chowdhury,Dharani Alagar Selvam et al.
Ayesha Nasreen et al.
Epigenetic mechanisms influence early developmental events, shaping gene expression in exciting ways that go beyond the DNA blueprint. The state of chromatin is governed by an interplay between various histone modifications, variants, nucle...
Reversible Histone Acetylation During Preimplantation Embryo Development in Mammals [0.03%]
哺乳动物卵裂期胚胎发育过程中组蛋白乙酰化的可逆性动态变化规律研究
Giulia Musmeci,Fernanda Fagali Franchi,Francesca Mossa et al.
Giulia Musmeci et al.
Histone acetylation is an epigenetic modification responsible for changes in chromatin architecture, accessibility, and ultimately gene expression. At the onset of a new life, when the fully differentiated parental genomes fuse together to ...
Tubulin Acetylation and the Cellular Mechanosensing and Stress Response [0.03%]
微管醋酸盐与细胞机械感应及压力响应之间的关系
Bruno Carmona,Inês L S Delgado,Sofia Nolasco et al.
Bruno Carmona et al.
Microtubule (MT) acetylation has emerged as a critical regulator of cellular stress responses, integrating mechanical and oxidative stimuli to support cellular adaptability and survival. This post-translational modification (PTM) enhances M...
Tubulin Acetylation: A Critical Regulator of Microtubule Function [0.03%]
微管上的α-管蛋白乙酰化修饰在细胞周期中的作用及机制研究进展
Inês L S Delgado,Bruno Carmona,Sofia Nolasco et al.
Inês L S Delgado et al.
The cytoskeleton is conserved throughout the eukaryotic lineage and consists of a complex dynamic network mainly composed of three distinct polymers: microtubules (MTs), actin filaments, and intermediate filaments. MTs are polymers of α/β...
Dale D Tang
Dale D Tang
The cytoskeleton of eukaryotic cells undergoes a reorganization in response to intracellular and extracellular cues, which plays an essential role in orchestrating various cell functions including migration, development, differentiation, ti...
Acetylation-Mediated Epigenetic Consequences for Biological Control and Cancer [0.03%]
乙酰化介导的表观遗传学后果在生物控制和癌症中的作用
Andrew J Fritz,Kyle T McKay,Haley W Greenyer et al.
Andrew J Fritz et al.
Acetylation of histones epigenetically mediates transcriptional dynamics of gene activation and suppression in response to physiological regulatory signals. The acetylated states of histone proteins define the activities of gene promoter an...
Histone and Non-histone Reversible Acetylation in Development, Aging, and Disease [0.03%]
组蛋白和非组蛋白可逆乙酰化在发育、衰老及疾病中的作用
Sezgin Gunes,Neslihan Hekim,Sercan Ergun et al.
Sezgin Gunes et al.
Post-translational modifications (PTM) involve chemical modifications of amino acid residues within histone and non-histone proteins and are chemically diverse. PTM plays a vital role in regulating the chromatin structure in the nucleus, th...