Damian Lewandowski,Małgorzata Daczewska
Damian Lewandowski
Skeletal muscles in vertebrates are highly specialised tissues. Their development involves cell cycle withdrawal, cellular fusion, and differentiation into multinucleated muscle fibres. Most insights into trunk muscle development have been ...
The Everlasting Ovary: Decoding the Mechanisms of Lifelong Oogenesis in the Naked Mole-Rat [0.03%]
裸鼹鼠终生产卵的机制解析：永恒的卵巢
Odei Barreñada,Andrew C Pearson,Miguel A Brieño-Enríquez
Odei Barreñada
The naked mole-rat (Heterocephalus glaber) is a fascinating model organism which challenges conventional paradigms in evolutionary developmental biology. As one of the two known eusocial mammals with a reproductive hierarchy akin to social ...
Peter K Dearden
Peter K Dearden
Evolution and development, as a field, seek to understand life's diversity. It asks questions about how diversity evolves, what constrains diversity, and how the mechanisms of development interact with evolution to produce different forms. ...
Jessica A Bolker
Jessica A Bolker
How model organisms work is shaped by both their biological and their epistemic contexts. In the case of evo-devo models, the epistemic context has shifted in important and interesting ways over the past few decades. In particular, both evo...
Alan C Love,Yoshinari Yoshida
Alan C Love
This chapter reflects on and makes explicit the distinctiveness of reasoning practices associated with model species in the context of evolutionary developmental research. Model species in evo-devo instantiate a unique synthesis of model sy...
Bromodomain and PHD Finger-Containing Protein 1: From Functions to a Developmental Disorder, Cancer, and Therapeutics [0.03%]
含溴结构域和PHD指结构域的蛋白1：从功能到发育障碍、癌症及治疗
Arezousadat Razavi,Paulina Varela-Castillo,Xiang-Jiao Yang
Arezousadat Razavi
Bromodomain and PHD finger-containing protein 1 (BRPF1) is an essential epigenetic regulator and plays a key role in post-translational modification of histones. It is a chromatin reader that recognizes acetylated histones and interacts wit...
Lysine Acetyltransferase 6 Complexes in Neurodevelopmental Disorders and Different Types of Cancer [0.03%]
神经发育障碍和不同类型癌症中的赖氨酸乙酰转移酶6复合体
Negar Mousavi,Xiang-Jiao Yang
Negar Mousavi
Lysine acetylation is a critical post-translational modification that regulates gene expression and cellular functions. The MYST family lysine acetyltransferases KAT6A (also known as MOZ and MYST3) and KAT6B (a.k.a. MORF and MYST4), in comp...
Chunran Feng,Yiqun Zeng,Edward V Prochownik et al.
Chunran Feng et al.
Over the last three decades, we have witnessed great progress in uncovering the scope of reversible acetylation of non-histone proteins and understanding its mechanisms and functional consequences. In this review, we summarize the histone a...
Matloob Husain
Matloob Husain
Viruses are acellular organisms and part of our ecosystem but exist at the interface of living and non-living. Furthermore, viruses are obligate intracellular parasites hence require the machinery of other organisms to multiply. Consequentl...
Repurposing Histone Deacetylase Inhibitors for Management of Solid Organ Transplant Rejection [0.03%]
组蛋白去乙酰化酶抑制剂在实体器官移植排斥反应管理中的再利用研究
Marta Halasa,Anna Wawruszak,Malgorzata Kloc
Marta Halasa
Histone deacetylase inhibitors (HDACi) have gained attention for their potential therapeutic effects in various immune-related diseases and solid organ transplantation. This review focuses on the role of HDACs' expression in immune response...