Mareike Sieler,Thomas Dittmar
Mareike Sieler
The natural phenomenon of cell-cell fusion does not only take place in physiological processes, such as placentation, myogenesis, or osteoclastogenesis, but also in pathophysiological processes, such as cancer. More than a century ago postu...
Felicite K Noubissi,Oluwatoyin V Odubanjo,Brenda M Ogle et al.
Felicite K Noubissi et al.
Cell-cell fusion is a normal physiological mechanism that requires a well-orchestrated regulation of intracellular and extracellular factors. Dysregulation of this process could lead to diseases such as osteoporosis, malformation of muscles...
Mateusz Matuszkiewicz,Mirosław Sobczak
Mateusz Matuszkiewicz
Plant-parasitic nematodes from the genera Globodera, Heterodera (cyst-forming nematodes), and Meloidogyne (root-knot nematodes) are notorious and serious pests of crops. They cause tremendous economic losses between US $80 and 358 billion a...
Mathematical Modeling of Virus-Mediated Syncytia Formation: Past Successes and Future Directions [0.03%]
病毒介导的合胞体形成的数学建模：过去的成功与未来的方向
Hana M Dobrovolny
Hana M Dobrovolny
Many viruses have the ability to cause cells to fuse into large multi-nucleated cells, known as syncytia. While the existence of syncytia has long been known and its importance in helping spread viral infection within a host has been unders...
Relevance of the Entry by Fusion at the Cytoplasmic Membrane vs. Fusion After Endocytosis in the HIV and SARS-Cov-2 Infections [0.03%]
融合过程对HIV和SARS-CoV-2感染的影响：细胞质膜与内吞作用后的融合对比分析
Leonor Huerta,Alejandro Gamboa-Meraz,Pablo Samuel Estrada-Ochoa
Leonor Huerta
HIV-1 and SARS-Cov-2 fuse at the cell surface or at endosomal compartments for entry into target cells; entry at the cell surface associates to productive infection, whereas endocytosis of low pH-independent viruses may lead to virus inacti...
Tobias Starling,Sergi Padilla-Parra
Tobias Starling
HIV-1 cell-free infection has been thoroughly investigated; however, its relevance and importance in vitro are questionable. Cell-cell transmission is now thought to be the dominant mode of transmission within the host; however precise mole...
Maorong Xie
Maorong Xie
Most enveloped viruses encode viral fusion proteins to penetrate host cell by membrane fusion. Interestingly, many enveloped viruses can also use viral fusion proteins to induce cell-cell fusion, both in vitro and in vivo, leading to the fo...
Jarred M Whitlock
Jarred M Whitlock
Skeletal muscle possesses a resident, multipotent stem cell population that is essential for its repair and maintenance throughout life. Here I highlight the role of this stem cell population in muscle repair and regeneration and review the...
Jiro Takito,Naoko Nonaka
Jiro Takito
Osteoclasts are multinucleated bone-resorbing cells derived from the monocyte/macrophage lineage. The macrophage colony-stimulating factor/receptor activator of nuclear factor κB ligand (M-CSF/RANKL) signaling network governs the different...
Jeffrey L Platt,Marilia Cascalho
Jeffrey L Platt
Evidence of fusion of somatic cells has been noted in health and in disease for more than a century. The most obvious but uncertain hallmark has been the presence of multiple nuclei in cells. Although multinucleated cells are found in norma...