Chronic Liver Allograft Rejection: Histopathological Insights and Future Directions [0.03%]
慢性肝脏移植排斥反应：病理组织学见解和未来发展方向
Samar Seeman,Joshua Wong,Adib Edilbi et al.
Samar Seeman et al.
Chronic liver allograft rejection (CR) remains a significant cause of late graft dysfunction and failure despite advances in surgical techniques and immunosuppression. This chapter reviews the current understanding of CR, integrating diagno...
Evolving Therapeutic Approaches for Treatment of Antibody-Mediated Rejection in Renal Allograft Recipients [0.03%]
肾移植受者抗抗体介导排斥反应治疗的演变疗法
Stanley C Jordan,Noriko Ammerman,Edmund Huang et al.
Stanley C Jordan et al.
Antibody-mediated rejection (AMR) is now recognized as the primary cause of the decline of functional integrity and ultimately, graft failure in kidney transplants. Evolving understanding of effectors responsible for B-cell activation and p...
Chronic Rejection in Facial Vascularized Composite Allotransplantation (fVCA) [0.03%]
面部血管化复合器官移植的慢性排斥反应
Felix J Klimitz,Leonard Knoedler,Samuel Knoedler et al.
Felix J Klimitz et al.
Chronic rejection (CR) remains a major barrier to long-term success in facial vascularized composite allotransplantation (fVCA), particularly in facial transplants. Unlike acute rejection, CR is a gradual, progressive process marked by vasc...
The Myeloid-T Lymphocyte Axis in Chronic Lung Allograft Rejection: Emerging Insights into the Immune Circuitry Driving Fibrosis [0.03%]
慢性肺移植排斥反应中的髓系-T淋巴细胞轴：驱动纤维化免疫环路的新见解
Sajad Moshkelgosha,Sumiha Ramendra,Ke Fan Bei et al.
Sajad Moshkelgosha et al.
While lung transplantation is a life-saving treatment option for patients with end-stage lung diseases, its long-term outcome is hampered by exceedingly high rates of chronic rejection, manifesting as chronic lung allograft dysfunction (CLA...
Vascular Remodeling in Chronic Rejection: Insights into Transplant Vasculopathy Across Solid Organ Allografts [0.03%]
慢性排斥反应中的血管重塑：移植血管病在实体器官异体移植中的见解
Samantha L Nelson,Sariah Hyacinth,Basmala Aldamak et al.
Samantha L Nelson et al.
Solid organ transplantation is an established treatment method for individuals with end-stage organ dysfunction. However, despite the common perception that transplantation offers a lasting cure, transplant recipients have limited long-term...
Donor-Derived Cell-Free DNA in Acute and Chronic Rejection of Solid Allograft Transplantation [0.03%]
器官移植急性或慢性排斥反应中的供者来源的无细胞DNA
Javier Muro-Perez,Manuel Muro-Perez,Jose Antonio Galian et al.
Javier Muro-Perez et al.
Today, there have been spectacular advances in surgical techniques, organ preservation for transplantation, optimal and efficient donor and recipient selection, more efficient diagnosis of transplant complications, and major progress in pha...
Malgorzata Kloc,Marta Halasa,Souhail A Thabet et al.
Malgorzata Kloc et al.
There is no cure for chronic rejection of transplanted organs. Macrophages are heavily involved in chronic rejection. Macrophages' movement into the graft depends on the actin cytoskeleton and its regulators the GTPase RhoA and its effector...
Pathogenesis of Chronic Rejection: Graft Endothelial Cell Trans-presentation of IL-15 Connects Alloantibody- and Cell-Mediated Steps in Allograft Vasculopathy [0.03%]
慢性移植排斥反应的发病机制：移植物内皮细胞将IL-15转递至抗体和T细胞介导排斥的中心位置连接起来以促进动脉硬化形成
Clancy W Mullan,Jordan S Pober
Clancy W Mullan
Chronic rejection of allografts appears mechanistically distinct from acute antibody-mediated and or acute cell-mediated rejection. Histological features point to roles for alloantibody and lymphocytic infiltrates, and allograft vasculopath...
The Role of the Endothelium as a Key Regulator of Chronic Transplant Rejection [0.03%]
内皮在慢性移植排斥反应中的关键调节作用
Wolfgang Jungraithmayr,Birte Ohm,Shampa Chatterjee
Wolfgang Jungraithmayr
The vascular endothelium serves as an indispensable border for the interaction and exchange of molecules and cells between the blood flow and tissues. Upon transplantation, the endothelium of the allograft is the first to come into contact ...
Exploring Chronic Rejection in Organ Transplantation Through Computational Modeling [0.03%]
通过计算模型探索器官移植中的慢性排斥反应
Stefano Casarin,Elisa Serafini
Stefano Casarin
Chronic rejection remains a significant challenge in solid organ transplantation, contributing to graft dysfunction and eventual failure despite advances in immunosuppressive therapies. Computational modeling has emerged as a powerful tool ...