Structural and immunocytochemical characterization of keratinization in vertebrate epidermis and epidermal derivatives [0.03%]
脊椎动物表皮及其衍生物角质化的结构和免疫细胞化学特征化
Lorenzo Alibardi
Lorenzo Alibardi
This review presents comparative aspects of epidermal keratinization in vertebrates, with emphasis on the evolution of the stratum corneum in land vertebrates. The epidermis of fish does not contain proteins connected with interkeratin matr...
Role of peripherin/rds in vertebrate photoreceptor architecture and inherited retinal degenerations [0.03%]
周边蛋白/rds在脊椎动物视杆细胞结构和遗传性视网膜变性中的作用
Andrew F X Goldberg
Andrew F X Goldberg
The vertebrate photoreceptor outer segment (OS) is a highly structured and dynamic organelle specialized to transduce light signals. The elaborate membranous architecture of the OS requires peripherin/rds (P/rds), an integral membrane prote...
Beixin Mo,Yu Chung Tse,Liwen Jiang
Beixin Mo
Multivesicular endosomes or prevacuolar compartments (PVCs) are membrane-bound organelles that play an important role in mediating protein traffic in the secretory and endocytic pathways of eukaryotic cells. PVCs function as an intermediate...
Elizabeth Harry,Leigh Monahan,Lyndal Thompson
Elizabeth Harry
The recent development of cell biology techniques for bacteria to allow visualization of fundamental processes in time and space, and their use in synchronous populations of cells, has resulted in a dramatic increase in our understanding of...
Marcus A Samuel,Jennifer N Salt,Shin-Han Shiu et al.
Marcus A Samuel et al.
Arm repeat domains are composed of multiple 42 amino acid Arm repeats and are found in the proteomes of all eukaryotic organisms. The Arm repeat domain is a highly conserved right-handed super helix of alpha-helices involved in protein-prot...
Organization and function of the actin cytoskeleton in developing root cells [0.03%]
发育根细胞中的肌动蛋白细胞骨架的组织和功能
Elison B Blancaflor,Yuh-Shuh Wang,Christy M Motes
Elison B Blancaflor
The actin cytoskeleton is a highly dynamic structure, which mediates various cellular functions in large part through accessory proteins that tilt the balance between monomeric G-actin and filamentous actin (F-actin) or by facilitating inte...
Da Young Oh,Kyungjin Kim,Hyuk Bang Kwon et al.
Da Young Oh et al.
The superfamily of G protein-coupled receptors (GPCRs) is the largest and most diverse group of membrane-spanning proteins. It plays a variety of roles in pathophysiological processes by transmitting extracellular signals to cells via heter...
Intracellular signals and events activated by cytokines of the tumor necrosis factor superfamily: From simple paradigms to complex mechanisms [0.03%]
肿瘤坏死因子家族细胞因子激活的胞内信号和事件：从简单模式到复杂机制
Sergei I Grivennikov,Dmitry V Kuprash,Zheng-Gang Liu et al.
Sergei I Grivennikov et al.
Tumor necrosis factor (TNF) and several related cytokines can induce opposite effects such as cell activation and proliferation or cell death. How the cell maintains the balance between these seemingly mutually exclusive pathways has long r...
Anton P Bussink,Marco van Eijk,G Herma Renkema et al.
Anton P Bussink et al.
Gaucher disease (GD) is the most common lysosomal storage disorder and is caused by inherited deficiencies of glucocerebrosidase, the enzyme responsible for the lysosomal breakdown of the lipid glucosylceramide. GD is characterized by the a...
Gareth J Howell,Zoe G Holloway,Christian Cobbold et al.
Gareth J Howell et al.
Understanding the molecular and cellular mechanisms underlying membrane traffic pathways is crucial to the treatment and cure of human disease. Various human diseases caused by changes in cellular homeostasis arise through a single gene mut...