Michael Schrader,H Dariush Fahimi
Michael Schrader
Peroxisomes are ubiquitous subcellular organelles, which are highly dynamic and display large plasticity in response to cellular and environmental conditions. Novel proteins and pathways that mediate and control peroxisome formation, growth...
Ivan Raska,Peter J Shaw,Dusan Cmarko
Ivan Raska
The nucleolus is the most obvious and clearly differentiated nuclear subcompartment. It is where ribosome biogenesis takes place and has been the subject of research over many decades. In recent years progress in our understanding of riboso...
Sub-second cellular dynamics: time-resolved electron microscopy and functional correlation [0.03%]
亚秒级细胞动态学：时间分辨电子显微镜与功能关联研究
Helmut Plattner,Joachim Hentschel
Helmut Plattner
Subcellular processes, from molecular events to organellar responses and cell movement, cover a broad scale in time and space. Clearly the extremes, such as ion channel activation are accessible only by electrophysiology, whereas numerous r...
Roles of DNA polymerases in replication, repair, and recombination in eukaryotes [0.03%]
真核生物中DNA聚合酶在复制、修复和重组中的作用
Youri I Pavlov,Polina V Shcherbakova,Igor B Rogozin
Youri I Pavlov
The functioning of the eukaryotic genome depends on efficient and accurate DNA replication and repair. The process of replication is complicated by the ongoing decomposition of DNA and damage of the genome by endogenous and exogenous factor...
Bernard A Kunz,David M Cahill,Peter G Mohr et al.
Bernard A Kunz et al.
Increased incident ultraviolet (UV) radiation due to ozone depletion has heightened interest in plant responses to UV because solar UV wavelengths can reduce plant genome stability, growth, and productivity. These detrimental effects result...
A two decade contribution of molecular cell biology to the centennial of Alzheimer's disease: are we progressing toward therapy? [0.03%]
分子细胞生物学对阿尔茨海默病研究的二十年贡献——我们是否接近治疗阿尔茨海默病？
Katleen Dillen,Wim Annaert
Katleen Dillen
Alzheimer's disease (AD), described for the first time 100 years ago, is a neurodegenerative disease characterized by two neuropathological hallmarks: neurofibrillary tangles containing hyperphosphorylated tau and senile plaques. These lesi...
Ben R Kiefel,Paul R Gilson,Peter L Beech
Ben R Kiefel
Mitochondria are the product of an ancient endosymbiotic event between an alpha-proteobacterium and an archael host. An early barrier to overcome in this relationship was the control of the bacterium's proliferation within the host. Undoubt...
Irina Guzhova,Boris Margulis
Irina Guzhova
Heat shock protein Hsp70 is implicated in the mechanism of cell reaction to a variety of cytotoxic factors. The protective function of Hsp70 is related to its ability to promote folding of nascent polypeptides and to remove denatured protei...
Romano Dallai,Pietro Lupetti,Caterina Mencarelli
Romano Dallai
Hexapod spermatozoa exhibit a great variation in their axoneme structure. The 9+2 pattern organization is present in a few basal taxa and in some derived groups. In most hexapods, a crown of nine accessory microtubules surrounds the 9+2 arr...
G I Bechan,R M Egeler,R J Arceci
G I Bechan
Langerhans cells (LC) are epidermal dendritic cells (DC). They play an important role in the initiation of immune responses through antigen uptake, processing, and presentation to T cells. Langerhans cell histiocytosis (LCH) is a rare disea...