YidC as an essential and multifunctional component in membrane protein assembly [0.03%]
YidC是一个在膜蛋白装配中不可或缺的多功能成分
Dorothee Kiefer,Andreas Kuhn
Dorothee Kiefer
Membrane proteins fulfill a number of vital functions in prokaryotic and eukaryotic cells. They are often organized in multicomponent complexes, folded within the membrane bilayer and interacting with the cytoplasmic and periplasmic or exte...
Aaron M Zorn,James M Wells
Aaron M Zorn
The embryonic endoderm gives rise to the epithelial lining of the digestive and respiratory systems and organs such as the thyroid, lungs, liver, gallbladder, and pancreas. Studies in Xenopus, zebrafish, and mice have revealed a conserved m...
Naoki Tanimizu,Atsushi Miyajima
Naoki Tanimizu
The liver is the central organ for metabolism and has strong regenerative capability. Although the liver has been studied mostly biochemically and histopathologically, genetic studies using gene-targeting technology have identified a number...
Development and role of tight junctions in the retinal pigment epithelium [0.03%]
屏障功能相关紧密连接蛋白在视网膜色素上皮的表达及作用研究进展
Lawrence J Rizzolo
Lawrence J Rizzolo
The outer blood-retinal barrier is formed by the retinal pigment epithelium. In any epithelial monolayer, the tight junctions enable the epithelium to form a barrier by joining neighboring cells together and regulating transepithelial diffu...
Samantha J Richardson
Samantha J Richardson
Advances in four areas of transthyretin (TTR) research result in this being a timely review. Developmental studies have revealed that TTR is synthesized in all classes of vertebrates during development. This leads to a new hypothesis on sel...
Achim Breiling,Luca Sessa,Valerio Orlando
Achim Breiling
Cellular phenotypes can be ascribed to different patterns of gene expression. Epigenetic mechanisms control the generation of different phenotypes from the same genotype. Thus differentiation is basically a process driven by changes in gene...
Mechanism of depolymerization and severing of actin filaments and its significance in cytoskeletal dynamics [0.03%]
肌动蛋白丝去聚合和断裂的机制及其在细胞骨架动力学中的意义
Shoichiro Ono
Shoichiro Ono
The actin cytoskeleton is one of the major structural components of the cell. It often undergoes rapid reorganization and plays crucial roles in a number of dynamic cellular processes, including cell migration, cytokinesis, membrane traffic...
Darko Marinkovic,Sanja Aleksic-Kovacevic,Pavle Plamenac
Darko Marinkovic
Chronic obstructive pulmonary disease (COPD) is an inflammatory obstructive disease of the airways characterized with hypersensitivity of the airway tissues to various allergens, most commonly the fungi contained in the poor-quality hay and...
Olga Greco,Simon Scott
Olga Greco
Hypoxia is an integral characteristic of the tumor microenvironment, primarily due to the microvascular defects that accompany the accelerated neoplastic growth. The presence of tumor hypoxic areas correlates with negative outcome after rad...
Ian A Darby,Tim D Hewitson
Ian A Darby
The contraction of granulation tissue from skin wounds was first described in the 1960s. Later it was discovered that during tissue repair, fibroblasts undergo a change in phenotype from their normal relatively quiescent state in which they...