Structure and function of the atypical orphan nuclear receptor small heterodimer partner [0.03%]
非典型孤儿核受体小异二聚体伴侣的结构与功能研究进展
Yong-Soo Lee,Dipanjan Chanda,Jeonggu Sim et al.
Yong-Soo Lee et al.
The small heterodimer partner (SHP; NROB2) is a member of the nuclear receptor superfamily and is classified as an "orphan" subgroup, as its ligand has not yet been identified. SHP lacks the classical DNA-binding domain found in most nuclea...
Merran C Derby,Paul A Gleeson
Merran C Derby
Protein transport in the secretory and endocytic pathways is a multistep process involving the generation of transport carriers loaded with defined sets of cargo, the shipment of the cargo-loaded transport carriers between compartments, and...
LEM-Domain proteins: new insights into lamin-interacting proteins [0.03%]
LEM-Domain蛋白的新见解——与核纤层相互作用的蛋白
Nicole Wagner,Georg Krohne
Nicole Wagner
LEM-domain proteins present a growing family of nonrelated inner nuclear membrane and intranuclear proteins, including emerin, MAN1, LEM2, several alternatively spliced isoforms of LAP2, and various uncharacterized proteins in higher eukary...
Molecular mechanism and evolutional significance of epithelial-mesenchymal interactions in the body- and tail-dependent metamorphic transformation of anuran larval skin [0.03%]
蛙类幼体皮肤身体部和尾部依赖型变态转型的上皮间质相互作用的分子机制及其进化意义
Katsutoshi Yoshizato
Katsutoshi Yoshizato
The epidermis of an anuran larva is composed of apical and skein cells that are both mitotically active and self-renewed through larval life. In contrast, the epidermis of an adult frog, with typical stratified squamous epithelium composed ...
Flagellar length control in chlamydomonas--paradigm for organelle size regulation [0.03%]
绿藻中的鞭毛长度调控及器官大小的调节机制研究
Kimberly A Wemmer,Wallace F Marshall
Kimberly A Wemmer
A fundamental unsolved question in cell biology is how the cell controls the size of its organelles. Cilia and flagella are an ideal test case to study the mechanism of organelle size control, because their size is easily measured and can b...
Sarah Mackay,Robert A Smith
Sarah Mackay
Since the discovery of the sex-determining gene Sry in 1990, research effort has focused on the events downstream of its expression. A range of different experimental approaches including gene expression, knocking-out and knocking-in genes ...
Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification [0.03%]
药I相和II相代谢酶的分子机制及其解毒意义
Takashi Iyanagi
Takashi Iyanagi
Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred to as drug-metabolizing enzymes (DMEs). DMEs can be classified into two main groups: oxidative or conjugative. The NADPH-cytochrome P450 reductase (...
Milijana Knezević,Sanja Aleksić-Kovacević,Zoran Aleksić
Milijana Knezević
Esophagogastric ulcer is an independent disease in swine that is characterized by ulcerous autodigestion of the cutaneous mucosa, which does not exhibit a tendency to recover, but, on the contrary, a tendency toward severe hemorrhaging, wit...
Deborah L Stenkamp
Deborah L Stenkamp
The retinas of teleost fish have long been of interest to developmental neurobiologists for their persistent plasticity during growth, life history changes, and response to injury. Because the vertebrate retina is a highly conserved tissue,...
Ingrid Brust-Mascher,Jonathan M Scholey
Ingrid Brust-Mascher
Mitosis, the process by which the replicated chromosomes are segregated equally into daughter cells, has been studied for over a century. Drosophila melanogaster is an ideal organism for this research. Drosophila embryos are well suited to ...