Mechanisms of gradient detection: a comparison of axon pathfinding with eukaryotic cell migration [0.03%]
梯度检测机制：轴突引导与真核细胞迁移的比较研究
Anne von Philipsborn,Martin Bastmeyer
Anne von Philipsborn
The detection of gradients of chemotactic cues is a common task for migrating cells and outgrowing axons. Eukaryotic gradient detection employs a spatial mechanism, meaning that the external gradient has to be translated into an intracellul...
Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis [0.03%]
极性调节子与上皮细胞形态、细胞迁移和肿瘤发生的关系
Lukas E Dow,Patrick O Humbert
Lukas E Dow
A large body of work on Drosophila melanogaster has identified and characterized a number of key polarity regulators, many of which are required for the regulation of multiple other processes including proliferation, migration, invasion, an...
Stefan A Juranek,Hans Joachim Lipps
Stefan A Juranek
During macronuclear differentiation in ciliated protozoa, most amazing "DNA gymnastics" takes place, which includes DNA excision, DNA elimination, DNA reorganization, and DNA-specific amplification. Although the morphological events occurri...
Microscopic morphology and the origins of the membrane maturation model of Golgi apparatus function [0.03%]
高尔基体功能的膜成熟模型的显微形态和起源
D James Morré,Hilton H Mollenhauer
D James Morré
The membrane maturation (flow differentiation) model of Golgi apparatus function embodies concepts of saccule formation at one face of the Golgi apparatus from membranes derived from endoplasmic reticulum and utilization of saccules in vesi...
New insights into glycosphingolipid functions--storage, lipid rafts, and translocators [0.03%]
糖鞘脂的新功能见解——储存、脂筏和转位酶
Dan J Sillence
Dan J Sillence
Glycosphingolipids are key components of eukaryotic cellular membranes. Through their propensity to form lipid rafts, they are important in membrane transport and signaling. At the cell surface, they are required for caveolar-mediated endoc...
Cell responses to biomimetic protein scaffolds used in tissue repair and engineering [0.03%]
仿生蛋白支架在组织修复和工程中的细胞反应
Robert A Brown,James B Phillips
Robert A Brown
Basic science research in tissue engineering and regenerative medicine aims to investigate and understand the deposition, growth, and remodeling of tissues by drawing together approaches from a range of disciplines. This review discusses ap...
Adhesion molecules and other secreted host-interaction determinants in Apicomplexa: insights from comparative genomics [0.03%]
粘附分子和其它分泌宿主相互作用决定因子在阿米巴原虫中的研究：比较基因组学的见解
Vivek Anantharaman,Lakshminarayan M Iyer,S Balaji et al.
Vivek Anantharaman et al.
Apicomplexa have developed distinctive adaptations for invading and surviving within animal cells. Here a synthetic overview of the diversity and evolutionary history of cell membrane-associated, -secreted, and -exported proteins related to...
Armando Felsani,Anna Maria Mileo,Vittoria Maresca et al.
Armando Felsani et al.
The amount of information on tumor biology has expanded enormously, essentially due to the completion of the human genome sequencing and to the application of new technologies that represent an exciting breakthrough in molecular analysis. O...
Calcium dynamics: spatio-temporal organization from the subcellular to the organ level [0.03%]
钙动态：从亚细胞到器官水平的时空组织规律
Geneviève Dupont,Laurent Combettes,Luc Leybaert
Geneviève Dupont
Many essential physiological processes are controlled by calcium. To ensure reliability and specificity, calcium signals are highly organized in time and space in the form of oscillations and waves. Interesting findings have been obtained a...
Laurel A Rohde,Carl-Philipp Heisenberg
Laurel A Rohde
Gastrulation is a morphogenetic process that results in the formation of the embryonic germ layers. Here we detail the major cell movements that occur during zebrafish gastrulation: epiboly, internalization, and convergent extension. Althou...