I F Zhimulev,E S Belyaeva,V F Semeshin et al.
I F Zhimulev et al.
Polytene chromosomes were described in 1881 and since 1934 they have served as an outstanding model for a variety of genetic experiments. Using the polytene chromosomes, numerous biological phenomena were discovered. First the polytene chro...
Ralph Gräf,Christine Daunderer,Irene Schulz
Ralph Gräf
The centrosome is a nonmembranous, nucleus-associated organelle that functions not only as the main microtubule-organizing center but also as a cell cycle control unit. How the approximately 100 different proteins that make up a centrosome ...
Microtubule-associated proteins and their essential roles during mitosis [0.03%]
与有丝分裂过程中微管结合蛋白及其重要作用相关的研究进展
Hélder Maiato,Paula Sampaio,Claudio E Sunkel
Hélder Maiato
Microtubules play essential roles during mitosis, including chromosome capture, congression, and segregation. In addition, microtubules are also required for successful cytokinesis. At the heart of these processes is the ability of microtub...
Biosynthesis and alternate targeting of the lysosomal cysteine protease cathepsin L [0.03%]
猫淋巴细胞白血病病毒LTR启动子的顺式调控元件分析表明存在负调节序列
John Collette,Jeffrey P Bocock,Kyujeong Ahn et al.
John Collette et al.
Upregulation of cathepsin L expression, whether during development or cell transformation, or mediated by ectopic expression from a plasmid, alters the targeting of the protease and thus its physiological function. Upregulated procathepsin ...
Taro Q P Uyeda,Akira Nagasaki,Shigehiko Yumura
Taro Q P Uyeda
The process of cytokinesis in animal cells is usually presented as a relatively simple picture: A cleavage plane is first positioned in the equatorial region by the astral microtubules of the anaphase mitotic apparatus, and a contractile ri...
Dick F Swaab
Dick F Swaab
A few examples of hypothalamic, peptidergic disorders leading to clinical signs and symptoms are presented in this review. Increased activity of corticotropin-releasing hormone (CRH) neurons in the paraventricular nucleus (PVN) and decrease...
Cellular distribution and functions of P2 receptor subtypes in different systems [0.03%]
P2受体亚型在不同系统中的细胞分布与功能
Geoffrey Burnstock,Gillian E Knight
Geoffrey Burnstock
This review is aimed at providing readers with a comprehensive reference article about the distribution and function of P2 receptors in all the organs, tissues, and cells in the body. Each section provides an account of the early history of...
Vincent Voisin,Sabine de la Porte
Vincent Voisin
Duchenne muscular dystrophy (DMD), a severe X-linked genetic disease affecting one in 3500 boys, is the most common myopathy in children. DMD is due to a lack of dystrophin, a submembrane protein of the cytoskeleton, which leads to the prog...
MAPping the eukaryotic tree of life: structure, function, and evolution of the MAP215/Dis1 family of microtubule-associated proteins [0.03%]
有丝分裂原纤维形成蛋白(MAP)与真核生物生命之树：MAP215/Dis1家族微管结合蛋白的结构、功能和进化关系研究
David L Gard,Bret E Becker,S Josh Romney
David L Gard
The MAP215/Dis1 family of proteins is an evolutionarily ancient family of microtubule-associated proteins, with characterized members in all major kingdoms of eukaryotes, including fungi (Stu2 in S. cerevisiae, Dis1 and Alp14 in S. pombe), ...
Patrick J Dimario
Patrick J Dimario
Nucleoli disassemble in prophase of the metazoan mitotic cycle, and they begin their reassembly (nucleologenesis) in late anaphase?early telophase. Nucleolar disassembly and reassembly were obvious to the early cytologists of the eighteenth...