Alberto Darszon,Takuya Nishigaki,Chris Wood et al.
Alberto Darszon et al.
Generating new life in animals by sexual reproduction depends on adequate communication between mature and competent male and female gametes. Ion channels are instrumental in the dialogue between sperm, its environment, and the egg. The abi...
Lutz Langbein,Jürgen Schweizer
Lutz Langbein
Substantial progress has been made regarding the elucidation of differentiation processes of the human hair follicle. This review first describes the genomic organization of the human hair keratin gene family and the complex expression char...
Nick Gilbert,Susan Gilchrist,Wendy A Bickmore
Nick Gilbert
Mammalian cells package their DNA into chromatin and arrange it in the nucleus as chromosomes. In interphase cells chromosomes are organized in a radial distribution with the most gene-dense chromosomes toward the center of the nucleus. Gen...
Intercellular coupling of interstitial cells of cajal in the digestive tract [0.03%]
消化道Cajal间质细胞的细胞间耦合现象
Menachem Hanani,Gianrico Farrugia,Terumasa Komuro
Menachem Hanani
Interstitial cells of Cajal (ICC) are essential for the normal function of the digestive tract, both as pacemakers and as intermediates between nerves and smooth muscle cells. To perform their functions ICC must be electrically coupled both...
Rajendra Prasad,Khyati Kapoor
Rajendra Prasad
The opportunistic human pathogens Candida albicans and other non-albicans species have acquired considerable significance in the recent past due to the enhanced susceptibility of immunocompromised patients. These pathogenic species of Candi...
The hypoxia-inducible factor and tumor progression along the angiogenic pathway [0.03%]
缺氧诱导因子与肿瘤沿血管生成途径的进展
M Christiane Brahimi-Horn,Jacques Pouysségur
M Christiane Brahimi-Horn
The hypoxia-inducible factor (HIF) is a transcription factor that plays a key role in the response of cells to oxygen levels. HIF is a heterodimer of alpha- and beta-subunits where the alpha-subunit is translated constitutively but has a ve...
H P Wiesmann,U Meyer,U Plate et al.
H P Wiesmann et al.
Collagen is the dominant fibrous protein not only in connective tissues but also in hard tissues, bone, dentin, cementum, and even the mineralizing cartilage of the epiphyseal growth plate. It comprises about 80-90% (by weight) of the organ...
François Képès,Alain Rambourg,Béatrice Satiat-Jeunemaître
François Képès
A careful scrutiny of the dynamics of secretory compartments in the entire eukaryotic world reveals many common themes. The most fundamental theme is that the Golgi apparatus and related structures appear as compartments formed by the act o...
Pathophysiological dynamics of human ovarian surface epithelial cells in epithelial ovarian carcinogenesis [0.03%]
人类卵巢表面上皮细胞在上皮性卵巢癌变中的病理生理学动态变化
Hitoshi Okamura,Hidetaka Katabuchi
Hitoshi Okamura
Epithelial ovarian cancer is responsible for almost half of all the deaths from female genital tract tumors. Major impediments to the clinical treatment of this disease are the relatively asymptomatic progression and a lack of knowledge reg...
Insect basic leucine zipper proteins and their role in cyclic AMP-dependent regulation of gene expression [0.03%]
昆虫泛素连接酶凋亡抑制蛋白家族成员及它们在cAMP依赖的基因表达调节中的作用
Jeroen Poels,Jozef Vanden Broeck
Jeroen Poels
The cAMP-protein kinase A (PKA) pathway is an important intracellular signal transduction cascade that can be activated by a large variety of stimuli. Activation or inhibition of this pathway will ultimately affect the transcriptional regul...